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Serum Chemerin, Vaspin, Oxidative Stress and Inflammation Markers in Subclinical Hypothyroidism/Hyperthyroidism

Year 2024, Volume: 8 Issue: 2, 296 - 307, 31.05.2024
https://doi.org/10.30621/jbachs.1256495

Abstract

Project Number

02/2017-24

References

  • Obregon MJ. Adipose tissues and thyroid hormones. Frontiers in Physiology 2014;5:1–12.
  • Chen Y, Wu X, Wu R, et al. Changes in profile of lipids and adipokines in patients with newly diagnosed hypothyroidism and hyperthyroidism. Scientific Reports 2016;19(6):1–7.
  • Edrees HM, Fahmy EK, Esmaeel SE. A Study on Serum Level of Chemerin in Experimentaly- Induced Thyroid Dysfunctions. Basic Sciences of Medicine 2018;7(2):21–6.
  • Alshaikh EM, Omar UM, Alsufiani HM, et al. The potential influence of hyperthyroidism on circulating adipokines chemerin, visfatin, and omentin. International journal of health sciences 2019;13(2):44–7.
  • González CR, Caminos JE, Vázquez MJ, et al. Regulation of visceral adipose tissue-derived serine protease inhibitor by nutritional status, metformin, gender and pituitary factors in rat white adipose tissue. Journal of Physiology 2009;587(14):3741–50.
  • De la Vega JR, Vilaplana JC, Biro A, Hammond L, Bottazzo GF, Mirakian R. IL-10 expression in thyroid glands: protective or harmful role against thyroid autoimmunity? Clin Exp Immunol. 1998;113(1):126–35.
  • Tuzcu A, Bahceci M, Gokalp D, Tuzun Y, Gunes K. Subclinical hypothyroidism may be associated with elevated high-sensitive C-reactive protein (low grade inflammation) and fasting hyperinsulinemia. Endocrine Journal 2005;52(1):89–94.
  • Barış N, Demir M, Ataytay A, Çuhadar S, Köseoğlu M. Hipotiroidizm ve hipertiroidizmde kardiyovasküler risk faktörleri. Yeni Tıp Dergisi 2011;28:30–3.
  • Ghiselli A, Serafini M, Natella F, Scaccini C. Total antioxidant capacity as a tool to assess redox status: Critical view and experimental data. Free Radical Biology and Medicine 2000;29(11):1106–14.
  • Patra RC, Swarup D, Dwivedi SK. Antioxidant effects of α tocopherol, ascorbic acid and L-methionine on lead induced oxidative stress to the liver, kidney and brain in rats. Toxicology 2001;162(2):81–8.
  • Ittermann T, Lorbeer R, Tiller D, et al. Serum Thyrotropin Concentrations Are Not Associated with the Ankle-Brachial Index: Results from Three Population-Based Studies. European Thyroid Journal 2015;4(1):101–7.
  • Cebeci E, Alibaz-Oner F, Usta M, Yurdakul S, Erguney M. Evaluation of Oxidative Stress, the Activities of Paraoxonase and Arylesterase in Patients With Subclinical Hypothyroidism. J Investig Med. 2012;60(1):23–8.
  • Marcocci C, Leo M, Altea MA. Oxidative Stress in Graves’ Disease. European Thyroid Journal 2012;1(2):80–7.
  • Vassalle C, Bianchi S, Bianchi F, Landi P, Battaglia D, Carpeggiani C. Oxidative stress as a predictor of cardiovascular events in coronary artery disease patients. Clinical Chemistry and Laboratory Medicine 2012;50(8):1463–8.
  • Rani AJ Mythili SV. Study on total antioxidant status in relation to oxidative stress in type 2 diabetes mellitus. Journal of Clinical and Diagnostic Research 2014;8(3):108–10.
  • Re R, Pellegrini N, Proteggente A, Pannala A, Yang M, Rice-Evans C. Antioxidant Activity Applying an Improved ABTS Radical Cation Decolorization Assay. Free Radical Biology & Medicin. 1999;26:1231–7.
  • Erel O. A novel automated direct measurement method for total antioxidant capacity using a new generation, more stable ABTS radical cation. Clin Biochem. 2004;37(4):277–85.
  • Gürel A, Doğantekin A, Özkan Y, Aydın S. Serum apelin levels in patients with thyroid dysfunction. International Journal of Clinical and Experimental Medicine 2015;8(9):16394–8.
  • Sanson M, Augé N, Vindis C, et al. Oxidized low-density lipoproteins trigger endoplasmic reticulum stress in vascular cells: Prevention by oxygen-regulated protein 150 expression. Circulation Research 2009;104(3):328–36.
  • Chen Y, Chen M, Wu Z, Zhao S. Ox-LDL induces ER stress and promotes the adipokines secretion in 3T3-L1 adipocytes. PLoS ONE 2013;8(10):1–8.
  • Berta E, Harangi M, Varga VE, et al. Evaluation of serum chemerin level in patients with hashimoto’s thyroiditis. Atherosclerosis 2016;252(2016):e168.
  • Lehrke M, Becker A, Greif M, et al. Chemerin is associated with markers of inflammation and components of the metabolic syndrome but does not predict coronary atherosclerosis. European Journal of Endocrinology 2009;161(2):339–44.
  • Chen X, Gao C, Gong N, Wang Y, Tian L. The change of left ventricular function in rats with subclinical hypothyroid and the effects of thyroxine replacement. International Journal of Endocrinology 2018;2018:1–10.
  • Gong N, Gao C, Chen X, Wang Y, Tian L. Adipokine expression and endothelial function in subclinical hypothyroidism rats. Endocrine Connections 2018;7(2):295–304.
  • Al-Jowari SA. Determination of the level of some adipokines in hypo-and hyperthyroids patients in Baghdad city. Baghdad Science Journal 2017;14(4):713–6.
  • Çinar N, Gülçelik NE, Aydín K, Akín Ş, Usman A, Gürlek A. Serum vaspin levels in hypothyroid patients. European Journal of Endocrinology 2011;165(4):563–9.
  • Salam MHA, Edrees HM. Effect of Different Conditions of Thyroid Function on Serum Adiponectin, Visfatin and Vaspin Levels in Rats. Basic Sciences of Medicine 2015;4(1):12–9.
  • Lumachi F, Basso SMM, Orlando R. Cytokines, thyroid diseases and thyroid cancer. Cytokine 2010;50(3):229–33.
  • Marchiori RC, Pereira LAF, Naujorks AA, et al. Improvement of blood inflammatory marker levels in patients with hypothyroidism under levothyroxine treatment. BMC Endocrine Disorders 2015;15(1):1–9.
  • Gómez-Zamudio JH, Mendoza-Zubieta V, Ferreira-Hermosillo A, et al. High Thyroid-stimulating Hormone Levels Increase Proinflammatory and Cardiovascular Markers in Patients with Extreme Obesity. Archives of Medical Research 2016;47(6):476–82.
  • Kvetny J, Heldgaard PE, Bladbjerg EM, Gram J. Subclinical hypothyroidism is associated with a low-grade inflammation, increased triglyceride levels and predicts cardiovascular disease in males below 50 years. Clinical Endocrinology 2004;61(2):232–8.
  • Şahin DA, Başpınar O. Thyroid Diseases. Turkiye Klinikleri Pediatric Sciences 2015;11(2):23–8.
  • Ittermann T, Baumeister SE, Völzke H, et al. Are serum TSH levels associated with oxidized low-density lipoprotein? Results from the study of health in Pomerania. Clinical Endocrinology 2012;76(4):526–32.
  • Ucan B, Kebapci MN, Uslu S, Kara M, Akcar Degirmenci N, Oner S. Hipotiroid hastalarda plazma visfatin konsantrasyonlarının tiroid otoimmünitesi ve ateroskleroz ile ilişkisi. Ortadoğu Tıp Dergisi 2018;10(4):498–505.
  • Duntas LH, Mantzou E, Koutras DA. Circulating Levels of Oxidized Low-Density Lipoprotein in Overt and Mild Hypothyroidism. Thyroid 2002;12(11):1003–7.
  • Cheserek MJ, Wu GR, Ntazinda A, Shi YH, Shen LY, Le GW. Association between Thyroid Hormones, Lipids and Oxidative Stress Markers in Subclinical Hypothyroidism. Journal of Medical Biochemistry 2015;34(3):323–31.
  • Ates I, Yilmaz FM, Altay M, Yilmaz N, Berker D, Güler S. The relationship between oxidative stress and autoimmunity in Hashimoto’s thyroiditis. European Journal of Endocrinology 2015;173(6):791–9.
  • Aslan M, Cosar N, Celik H, et al. Evaluation of oxidative status in patients with hyperthyroidism. Endocrine 2011;40(2):285–9.

Serum Chemerin, Vaspin, Oxidative Stress and Inflammation Markers in Subclinical Hypothyroidism/Hyperthyroidism

Year 2024, Volume: 8 Issue: 2, 296 - 307, 31.05.2024
https://doi.org/10.30621/jbachs.1256495

Abstract

Purpose: Subclinical thyroid diseases constitute the first stage of clinical thyroid, so it is important to investigate underlying mechanisms. Clinical studies have revealed changes in some adipokines concerning thyroid disorders. Relationship chemerin and vaspin adipokines with thyroid hormones are not clear. So, it was aimed to evaluate chemerin, vaspin, oxidative stress and inflammation markers in subclinical hypothyroidism/hyperthyroidism.
Material and Methods: The study included 38 SubHyper, 31 SubHypo and 44 controls. Serum chemerin, vaspin, IL-10, CRP, and Ox-LDL were measured with ELISA, while TAS and TOS were spectrofometric method.
Results: Serum chemerin were higher in SubHypo, while lower in SubHyper compared to controls. Vaspin levels of subclinical thyroid patients were lower than controls. IL-10 were lower in SubHyper; CRP were higher in both patient groups than controls. TAS were higher in SubHypo; TOS and OSI were lower in SubHyper patients.
Conclusion: Increased total antioxidant and CRP in SubHypo and decreased total oxidants, IL-10 and OSI in SubHyper indicated that oxidant-antioxidant balance is impaired suggesting that subclinical thyroid diseases may cause changes in inflammation and defense mechanism. Decrease in chemerin in SubHyper and vaspin in SubHypo and SubHyper show that chemerin and vaspin may be candidates as biomarkers in subclinical thyroid diseases.

Supporting Institution

GAZI University Projects of Scientific Investigation (GÜBAP)

Project Number

02/2017-24

References

  • Obregon MJ. Adipose tissues and thyroid hormones. Frontiers in Physiology 2014;5:1–12.
  • Chen Y, Wu X, Wu R, et al. Changes in profile of lipids and adipokines in patients with newly diagnosed hypothyroidism and hyperthyroidism. Scientific Reports 2016;19(6):1–7.
  • Edrees HM, Fahmy EK, Esmaeel SE. A Study on Serum Level of Chemerin in Experimentaly- Induced Thyroid Dysfunctions. Basic Sciences of Medicine 2018;7(2):21–6.
  • Alshaikh EM, Omar UM, Alsufiani HM, et al. The potential influence of hyperthyroidism on circulating adipokines chemerin, visfatin, and omentin. International journal of health sciences 2019;13(2):44–7.
  • González CR, Caminos JE, Vázquez MJ, et al. Regulation of visceral adipose tissue-derived serine protease inhibitor by nutritional status, metformin, gender and pituitary factors in rat white adipose tissue. Journal of Physiology 2009;587(14):3741–50.
  • De la Vega JR, Vilaplana JC, Biro A, Hammond L, Bottazzo GF, Mirakian R. IL-10 expression in thyroid glands: protective or harmful role against thyroid autoimmunity? Clin Exp Immunol. 1998;113(1):126–35.
  • Tuzcu A, Bahceci M, Gokalp D, Tuzun Y, Gunes K. Subclinical hypothyroidism may be associated with elevated high-sensitive C-reactive protein (low grade inflammation) and fasting hyperinsulinemia. Endocrine Journal 2005;52(1):89–94.
  • Barış N, Demir M, Ataytay A, Çuhadar S, Köseoğlu M. Hipotiroidizm ve hipertiroidizmde kardiyovasküler risk faktörleri. Yeni Tıp Dergisi 2011;28:30–3.
  • Ghiselli A, Serafini M, Natella F, Scaccini C. Total antioxidant capacity as a tool to assess redox status: Critical view and experimental data. Free Radical Biology and Medicine 2000;29(11):1106–14.
  • Patra RC, Swarup D, Dwivedi SK. Antioxidant effects of α tocopherol, ascorbic acid and L-methionine on lead induced oxidative stress to the liver, kidney and brain in rats. Toxicology 2001;162(2):81–8.
  • Ittermann T, Lorbeer R, Tiller D, et al. Serum Thyrotropin Concentrations Are Not Associated with the Ankle-Brachial Index: Results from Three Population-Based Studies. European Thyroid Journal 2015;4(1):101–7.
  • Cebeci E, Alibaz-Oner F, Usta M, Yurdakul S, Erguney M. Evaluation of Oxidative Stress, the Activities of Paraoxonase and Arylesterase in Patients With Subclinical Hypothyroidism. J Investig Med. 2012;60(1):23–8.
  • Marcocci C, Leo M, Altea MA. Oxidative Stress in Graves’ Disease. European Thyroid Journal 2012;1(2):80–7.
  • Vassalle C, Bianchi S, Bianchi F, Landi P, Battaglia D, Carpeggiani C. Oxidative stress as a predictor of cardiovascular events in coronary artery disease patients. Clinical Chemistry and Laboratory Medicine 2012;50(8):1463–8.
  • Rani AJ Mythili SV. Study on total antioxidant status in relation to oxidative stress in type 2 diabetes mellitus. Journal of Clinical and Diagnostic Research 2014;8(3):108–10.
  • Re R, Pellegrini N, Proteggente A, Pannala A, Yang M, Rice-Evans C. Antioxidant Activity Applying an Improved ABTS Radical Cation Decolorization Assay. Free Radical Biology & Medicin. 1999;26:1231–7.
  • Erel O. A novel automated direct measurement method for total antioxidant capacity using a new generation, more stable ABTS radical cation. Clin Biochem. 2004;37(4):277–85.
  • Gürel A, Doğantekin A, Özkan Y, Aydın S. Serum apelin levels in patients with thyroid dysfunction. International Journal of Clinical and Experimental Medicine 2015;8(9):16394–8.
  • Sanson M, Augé N, Vindis C, et al. Oxidized low-density lipoproteins trigger endoplasmic reticulum stress in vascular cells: Prevention by oxygen-regulated protein 150 expression. Circulation Research 2009;104(3):328–36.
  • Chen Y, Chen M, Wu Z, Zhao S. Ox-LDL induces ER stress and promotes the adipokines secretion in 3T3-L1 adipocytes. PLoS ONE 2013;8(10):1–8.
  • Berta E, Harangi M, Varga VE, et al. Evaluation of serum chemerin level in patients with hashimoto’s thyroiditis. Atherosclerosis 2016;252(2016):e168.
  • Lehrke M, Becker A, Greif M, et al. Chemerin is associated with markers of inflammation and components of the metabolic syndrome but does not predict coronary atherosclerosis. European Journal of Endocrinology 2009;161(2):339–44.
  • Chen X, Gao C, Gong N, Wang Y, Tian L. The change of left ventricular function in rats with subclinical hypothyroid and the effects of thyroxine replacement. International Journal of Endocrinology 2018;2018:1–10.
  • Gong N, Gao C, Chen X, Wang Y, Tian L. Adipokine expression and endothelial function in subclinical hypothyroidism rats. Endocrine Connections 2018;7(2):295–304.
  • Al-Jowari SA. Determination of the level of some adipokines in hypo-and hyperthyroids patients in Baghdad city. Baghdad Science Journal 2017;14(4):713–6.
  • Çinar N, Gülçelik NE, Aydín K, Akín Ş, Usman A, Gürlek A. Serum vaspin levels in hypothyroid patients. European Journal of Endocrinology 2011;165(4):563–9.
  • Salam MHA, Edrees HM. Effect of Different Conditions of Thyroid Function on Serum Adiponectin, Visfatin and Vaspin Levels in Rats. Basic Sciences of Medicine 2015;4(1):12–9.
  • Lumachi F, Basso SMM, Orlando R. Cytokines, thyroid diseases and thyroid cancer. Cytokine 2010;50(3):229–33.
  • Marchiori RC, Pereira LAF, Naujorks AA, et al. Improvement of blood inflammatory marker levels in patients with hypothyroidism under levothyroxine treatment. BMC Endocrine Disorders 2015;15(1):1–9.
  • Gómez-Zamudio JH, Mendoza-Zubieta V, Ferreira-Hermosillo A, et al. High Thyroid-stimulating Hormone Levels Increase Proinflammatory and Cardiovascular Markers in Patients with Extreme Obesity. Archives of Medical Research 2016;47(6):476–82.
  • Kvetny J, Heldgaard PE, Bladbjerg EM, Gram J. Subclinical hypothyroidism is associated with a low-grade inflammation, increased triglyceride levels and predicts cardiovascular disease in males below 50 years. Clinical Endocrinology 2004;61(2):232–8.
  • Şahin DA, Başpınar O. Thyroid Diseases. Turkiye Klinikleri Pediatric Sciences 2015;11(2):23–8.
  • Ittermann T, Baumeister SE, Völzke H, et al. Are serum TSH levels associated with oxidized low-density lipoprotein? Results from the study of health in Pomerania. Clinical Endocrinology 2012;76(4):526–32.
  • Ucan B, Kebapci MN, Uslu S, Kara M, Akcar Degirmenci N, Oner S. Hipotiroid hastalarda plazma visfatin konsantrasyonlarının tiroid otoimmünitesi ve ateroskleroz ile ilişkisi. Ortadoğu Tıp Dergisi 2018;10(4):498–505.
  • Duntas LH, Mantzou E, Koutras DA. Circulating Levels of Oxidized Low-Density Lipoprotein in Overt and Mild Hypothyroidism. Thyroid 2002;12(11):1003–7.
  • Cheserek MJ, Wu GR, Ntazinda A, Shi YH, Shen LY, Le GW. Association between Thyroid Hormones, Lipids and Oxidative Stress Markers in Subclinical Hypothyroidism. Journal of Medical Biochemistry 2015;34(3):323–31.
  • Ates I, Yilmaz FM, Altay M, Yilmaz N, Berker D, Güler S. The relationship between oxidative stress and autoimmunity in Hashimoto’s thyroiditis. European Journal of Endocrinology 2015;173(6):791–9.
  • Aslan M, Cosar N, Celik H, et al. Evaluation of oxidative status in patients with hyperthyroidism. Endocrine 2011;40(2):285–9.
There are 38 citations in total.

Details

Primary Language English
Subjects Health Care Administration
Journal Section Research Article
Authors

Sümeyye Tamer 0000-0003-4956-2015

Taylan Turan 0000-0001-7335-1213

Tuba Taşkan 0000-0003-1677-5356

Mehmet Ayhan Karakoç 0000-0002-0601-6893

İsmail Emre Arslan 0000-0003-4460-8598

Aymelek Gönenç 0000-0001-9661-8291

Project Number 02/2017-24
Publication Date May 31, 2024
Submission Date February 27, 2023
Published in Issue Year 2024 Volume: 8 Issue: 2

Cite

APA Tamer, S., Turan, T., Taşkan, T., Karakoç, M. A., et al. (2024). Serum Chemerin, Vaspin, Oxidative Stress and Inflammation Markers in Subclinical Hypothyroidism/Hyperthyroidism. Journal of Basic and Clinical Health Sciences, 8(2), 296-307. https://doi.org/10.30621/jbachs.1256495
AMA Tamer S, Turan T, Taşkan T, Karakoç MA, Arslan İE, Gönenç A. Serum Chemerin, Vaspin, Oxidative Stress and Inflammation Markers in Subclinical Hypothyroidism/Hyperthyroidism. JBACHS. May 2024;8(2):296-307. doi:10.30621/jbachs.1256495
Chicago Tamer, Sümeyye, Taylan Turan, Tuba Taşkan, Mehmet Ayhan Karakoç, İsmail Emre Arslan, and Aymelek Gönenç. “Serum Chemerin, Vaspin, Oxidative Stress and Inflammation Markers in Subclinical Hypothyroidism/Hyperthyroidism”. Journal of Basic and Clinical Health Sciences 8, no. 2 (May 2024): 296-307. https://doi.org/10.30621/jbachs.1256495.
EndNote Tamer S, Turan T, Taşkan T, Karakoç MA, Arslan İE, Gönenç A (May 1, 2024) Serum Chemerin, Vaspin, Oxidative Stress and Inflammation Markers in Subclinical Hypothyroidism/Hyperthyroidism. Journal of Basic and Clinical Health Sciences 8 2 296–307.
IEEE S. Tamer, T. Turan, T. Taşkan, M. A. Karakoç, İ. E. Arslan, and A. Gönenç, “Serum Chemerin, Vaspin, Oxidative Stress and Inflammation Markers in Subclinical Hypothyroidism/Hyperthyroidism”, JBACHS, vol. 8, no. 2, pp. 296–307, 2024, doi: 10.30621/jbachs.1256495.
ISNAD Tamer, Sümeyye et al. “Serum Chemerin, Vaspin, Oxidative Stress and Inflammation Markers in Subclinical Hypothyroidism/Hyperthyroidism”. Journal of Basic and Clinical Health Sciences 8/2 (May 2024), 296-307. https://doi.org/10.30621/jbachs.1256495.
JAMA Tamer S, Turan T, Taşkan T, Karakoç MA, Arslan İE, Gönenç A. Serum Chemerin, Vaspin, Oxidative Stress and Inflammation Markers in Subclinical Hypothyroidism/Hyperthyroidism. JBACHS. 2024;8:296–307.
MLA Tamer, Sümeyye et al. “Serum Chemerin, Vaspin, Oxidative Stress and Inflammation Markers in Subclinical Hypothyroidism/Hyperthyroidism”. Journal of Basic and Clinical Health Sciences, vol. 8, no. 2, 2024, pp. 296-07, doi:10.30621/jbachs.1256495.
Vancouver Tamer S, Turan T, Taşkan T, Karakoç MA, Arslan İE, Gönenç A. Serum Chemerin, Vaspin, Oxidative Stress and Inflammation Markers in Subclinical Hypothyroidism/Hyperthyroidism. JBACHS. 2024;8(2):296-307.