The diagnostic value of mean platelet volume in males with premature atherosclerotic coronary artery disease having stable angina pectoris

Abstract

Objective: In this study, we aimed to investigate whether platelet count and mean platelet volume (MPV) could be new biomarkers addition to classical risk factors in premature coronary artery disease (CAD). Methods: Totally 124 male patients (mean age: 45.8±13.0 year; range of age: 27-78 year), with stable angina pectoris, were included. Clinical and laboratory findings (whole blood cell count, glucose, creatinine, lipid profile) were recorded. Automatic blood counter was used for hematological parameters. Conventional coronary angiography was performed. Patients having acute coronary syndrome within the last six months, with severe valvular, structural or congenital heart disease, thyroid and hepatic dysfunction or signs of any infection were excluded. Results: The study population were separated into three groups by coronary angiography: 51 with stable CAD aged ≤40 years (premature CAD), 38 with stable CAD older than 40 (mature CAD) and 35 with the normal coronary arteries (NCA). No significant difference was found in MPV values between premature CAD and mature CAD and also between premature CAD and NCA (p>0.05). A significant negative correlation was found between MPV and platelet count in premature CAD (r=-0.419, p=0.002). Both in premature CAD and mature CAD groups, higher MPV values was found in critical CAD subgroup than noncritical CAD subgroup, but the difference was not statistically significant (p>0.05). Conclusion: There was no significant difference in MPV between premature and mature male CAD patients compared to NCA group. A positive but non-significant correlation was found between the MPV values and the severity of CAD. J Clin Exp Invest 2014; 5 (3): 381-385

Keywords

• Mean platelet volume, platelet count, premature atherosclerotic coronary artery disease, stable angina pectoris

Kararlı anjina pektorisli prematür aterosklerotik koroner arter hastalığı olan erkeklerde trombosit sayısı ve ortalama trombosit hacminin tanısal değeri

Abstract

Amaç: Bu çalışmada prematür koroner arter hastalığı (KAH)\'nda, klasik risk faktörleri yanında trombosit sayısı ve ortalama trombosit hacmi (OTH)\'nin ek bir biyobelirteç olup olmadığını araştırmayı amaçladık. Yöntemler: Çalışmaya kararlı anjina pektoris (AP) yakınması olan 124 erkek hasta (ortalama yaş: 45,8±13,0 yıl; yaş aralığı: 27-78 yıl) alınmıştır. Hastaların klinik ve laboratuvar verileri (tam kan sayımı, glukoz, kreatinin, lipid profili) kaydedilmiştir. Hematolojik parametreler otomatik kan sayım cihazı ile ölçülmüştür. Tüm hastalar konvansiyonel koroner anjiyografi ile değerlendirilmiştir. Son 6 ay içinde akut koroner sendrom geçiren, kalp kapak hastalığı, yapısal veya konjenital kalp hastalığı, tiroid ve/veya karaciğer fonksiyon bozukluğu, aktif enfeksiyon bulguları olan hastalar çalışma dışı bırakılmıştır. Bulgular: Çalışmaya alınan 124 erkek hasta; kırk yaş ve altı (≤40) kararlı AP\'si olanlar (prematür KAH) (n=51), kırk yaş üstü (>40) kararlı AP\'si olanlar (matür KAH) (n=38) ve yaşlarına bakılmaksızın koroner anjiyografide normal koroner arterler (NKA) tespit edilenler (n=35) olmak üzere 3 gruba ayrılmıştır. Prematür KAH ile matür KAH ve prematür KAH ile NKA\'lar OTH düzeyi açısından karşılaştırıldığında anlamlı fark bulunmadı (p>0,05). Prematür KAH olanlarda OTH ile trombosit sayısı arasında istatistiksel olarak anlamlı bir korelasyon izlendi ve bu korelasyon karşıt yönlü idi (r=−0,419, p=0,002). Ciddi KAH olan prematür ve matür KAH olgularında hafif KAH olanlarla karşılaştırıldığında OTH daha yüksek olmakla beraber aradaki fark istatistiksel olarak anlamlı değildi (p>0,05). Sonuç: Kararlı AP\'li prematür KAH olan erkek hastalar, matür KAH olan veya NKA tespit edilenlerle karşılaştırıldığında OTH düzeyi açısından anlamlı fark saptanmadı. Ancak KAH\'ın ciddiyeti ile OTH arasında istatistiksel olarak anlamlı olmayan doğrusal bir ilişki bulundu.

Keywords

• Kararlı anjina pektoris, ortalama trombosit hacmi, prematür aterosklerotik koroner arter hastalığı, trombosit sayısı

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