Evaluation of efficacy, safety and antioxidant effect of Nigella sativa in patients with psoriasis: A randomized clinical trial

Year 2014, , 186 - 193, 01.06.2014

Jawad Hassan Ahmed Azhar Younis Ibraheem Khalil Ismaeel Al-hamdi

https://doi.org/10.5799/ahinjs.01.2014.02.0387

Cited By: 3

Abstract

Objective: Various drugs are used for treatment of psoriasis such as retinoids, hydroxyurea, methotrexate, and infliximab with variable benefits, but these drugs are associated with side effects. The aim of this study was to evaluate efficacy, safety of topical and oral doses of Nigella sativa (NS) in psoriatic patients. Methods: sixty patients with mild to moderate plaque and palmoplanter psoriasis were recruited for the study from January 2010 to March 2011. The patients were randomly divided into three groups: Twenty patients (group 1) were treated with (10% w/w) ointment of (NS), group 2 (20 patients) treated with crude powder of (NS), 500mg capsule t.d.s; group 3 (20 patients) were treated with the combination of ointment and capsule of (NS).PASI score was used for clinical evaluation of effect, and serum malondialdehyde (MDA) as an indicator of oxidative status. Results: (NS) ointment achieved complete cure of psoriatic lesions, excellent and good response in 65% of patients, with a relapse rate of 31% four weeks after cessation of treatment. Oral doses of (NS) produced good response in 50% of patients, with a relapse rate of 50% noticed four weeks after treatment cessation. The combination of (NS) ointment and oral doses achieved complete cure of lesions, excellent and good responses in 85% of patients, with a relapse rate of 18%. (NS) was well tolerated, no side effects were observed. Conclusion: (NS) has anti psoriatic effect with the best effect obtained with the combination of ointment and the oral dosage form of (NS). J Clin Exp Invest 2014; 5 (2): 186-193

Keywords

Nigella sativa, Plague psoriasis, antioxidant, efficacy

Psöriazisli hastalarda çörek otunun etkinlik, güvenirlik ve antioksidan etkileri: Randomize bir klinik çalışma

Abstract

Amaç: Psöriazis tedavisinde retinoidler, hidroksiüre, metotreksat ve infliksimab gibi pek çok ilaç farklı etkinlikleriyle kullanılmıştır. Ancak bu ilaçların yan etkileri vardır. Bu çalışmanın amacı, pöriatik hastalarda çörek otunun topikal ve oral dozlarının etkinlik ve güvenirliğini değerlendirmektir. Yöntemler: Hafif ve orta plaklı ve palmoplantar psöriazisli 60 hasta Ocak 2010 ile Mart 2011 arasında çalışmaya alındı. Hastalar rastgele üç gruba ayrıldı: 20 hasta (Grup 1) %10\'luk çörek otu merhemi ile, Grup 2\'deki 20 hasta çörek otunun 500 mg\'lık kuru tozunu içeren kapsüller ile günde 3 defa tedavi edildi. Grup 3\'teki 20 hasta ise hem çörek otu merhemi, hem de kapsülleri ile tedavi edildi. PASı skoru etkinliğin değerlendirilmesi ve serum malondialdehid düzeyi oksidatif durum belirteci olarak kullanıldı. Bulgular: Çörek otu merhemi ile psöriyatik lezyonlarda %65 oranında tam düzelme veya mükemmel ve iyi cevap alındı. Oral çörek otu hastaların %50\'sinde iyi cevap verdi, ancak tedavi kesilmesinden 4 hafta sonra %50 oranında rölaps gözlendi. Merhem ve oral çörek otu kombinasyonu ile vakaların %85\'inde mükemmel ve iyi cevap alındı ve kombinasyon tedavisi sonrası %18 rölaps oldu. Çörek otu iyi tolere edildi ve herhangi bir yan etki gözlenmedi. Sonuçlar: Çörek otu antipsöriatik etkilre sahiptir ve bu etkiler en iyi merhem ve oral formlarının kombine verilmesi ile elde edilir.

Keywords

Çörek otu, psöriazis plakları, antioksidan etki, etkinlik

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