Primary cutaneous follicle center lymphoma in a 77-year-old woman

Abstract

Cutaneous B-cell lymphoma is characterized by monoclonal proliferation of the B-lymphocytes and usually limited to the skin. Primary cutaneous follicle center lymphoma is the most common cutaneous B-cell lymphoma, which is formed by clonal proliferation of centrocytes and centroblasts in follicular or diffuse pattern. Here we present a case of 77-year-old woman patient who had acomplaint of pruritic swellings on her scalp and diagnosed as primary cutaneous follicle center lymphoma. In this manner, we would like to remind this disease which we do not frequently meet in daily practice and emphasize to consider lymphoma in the differential diagnosis of these kind of lesions. J Clin Exp Invest 2013; 4 (4): 521-524

Keywords

• B-cell lymphoma, primary cutaneous, B-lymphocytes

Primary cutaneous follicle center lymphoma in a 77-year-old woman

Öz

Kütanöz B hücreli lenfoma, B lenfositlerin monoklonal proliferasyonu ile karakterize genellikle deriye sınırlı kalan lenfoma tipidir. Primer kütanöz folikül merkez hücreli lenfoma, sentrosit ve sentroblastların foliküler veya diffüz paternde klonal proliferasyonu sonucu oluşan kütanöz B hücreli lenfomaların en sık görülen tipidir. Burada saçlı deride kaşıntılı kabarıklıklar şikayeti ile başvurup, kütanöz folikül merkez hücreli lenfoma tanısı konulan 77 yaşındaki kadın hasta, hastalığın nadir görülmesi nedeniyle sunulmaktadır. Böylelikle, günlük pratikte çok sık olarak karşılaşmadığımız bu hastalık grubunu; bu olgu vasıtasıyla hatırlatmak ve bu tür lezyonların ayırıcı tanısında lenfomayı düşünmek gerektiğini vurgulamak istedik.

Anahtar Kelimeler

• B hücreli lenfoma, primer kütanöz, B lenfositler

References

1. Swerdlow SH, Campo E, Harris NL, et al. (Eds). World Health Organization Classification of Tumours of Hae- matopoietic and Lymphoid Tissues. IARC Press, Lyon 2008.
2. Kempf W, Denisjuk N, Kerl K, et al. Primary cutane- ous B-cell lymphomas. J Deutsch Dermatol Ges 2012;10:12-23.
3. Bogle M, Riddle C, Triana E, Jones D, Duvic M. Prima- ry cutaneous B-cell lymphoma. J Am Acad Dermatol 2005;53:478-483.
4. Senff NJ, Hoefnagel JJ, Jansen PM, et al. Reclassifi- cation of 300 primary cutaneous B-Cell lymphomas according to the new WHO-EORTC classification for cutaneous lymphomas: comparison with previous classifications and identification of prognostic mark- ers. J Clin Oncol 2007;25:1581-1587.
5. Zinzani PL, Quaglino P, Pimpinelli N, et al. Prognos- tic factors in primary cutaneous B-cell lymphoma: the Italian Study Group for Cutaneous Lymphomas. J Clin Oncol 2006;24:1376-1382.
6. Franco R, Fernandez-Vazquez A, Rodriguez-Peralto JL, et al. Cutaneous follicular B-cell lymphoma: de- scription of a series of 18 cases. Am J Surg Pathol 2001;25:875-883.
7. Massone C, Fink-Puches R, Laimer M, et al. Miliary and agminated-type primary cutaneous follicle center lymphoma: report of 18 cases. J Am Acad Dermatol 2011;65:749-755.
8. Gulia A, Saggini A, Wiesner T, et al. Clinicopathologic features of early lesions of primary cutaneous fol- licle center lymphoma, diffuse type: implications for early diagnosis and treatment. J Am Acad Dermatol 2011;65:991-1000.

9. Grange F, Hedelin G, Joly P, et al. Prognostic factors in primary cutaneous lymphomas other than myco- sis fungoides and the Sézary syndrome. The French Study Group on Cutaneous Lymphomas. Blood 1999;93:3637-3642.
10. Senff NJ, Noordijk EM, Kim YH, et al. European Or- ganization for Research and Treatment of Cancer and International Society for Cutaneous Lymphoma consensus recommendations for the management of cutaneous B-cell lymphomas. Blood 2008;112:1600- 1609.