Radiologic findings of olfactory neuroblastoma (Esthesioblastoma)

Abstract

Olfactory neuroblastoma (ONB) also known as esthesioblastoma is a rare malignant neoplasm originating from olfactive epitelium, usually locate in the olfactory region of the nasal cavity and anterior skull base. Few cases have been published in the literature yet. Detailed radiologic and histopathological examination is necessary for diagnosis and staging ONB. Prognosis is favorable especially for locally advanced tumors; regional and distant metastasis has been accepted as indicators of poor prognosis. Surgery and radiotherapy are the main therapeutic modalities in use today. We reported the x-ray graphic, B Mod-Doppler Ultrasound (US) and Computed Tomography (CT) findings of 64 years-old male with ONB in this presentation. J Clin Exp Invest 2013; 4 (4): 532-534

Keywords

• Olfactory neuroblastoma, esthesioblastoma, cribriform plate

Radiologic findings of olfactory neuroblastoma (Esthesioblastoma)

Öz

Olfaktör nöroblastoma (ONB), diğer bir isimle esthesioblastoma, olfaktör epitelyumdan köken olan, genellikle nazal kavite olfaktör bölgede ve ön kafa tabanında yer alan nadir malign bir neoplazidir. Bugüne kadar literatürde az sayıda vaka bildirilmiştir. ONB tanısı ve sınıflandırması için ayrıntılı radyolojik ve histopatolojik inceleme gereklidir. Özellikle lokal seyreden tümörlerde prognoz iyi seyirli olup bölgesel ve uzak metastaz kötü prognoz belirtileri olarak kabul edilmiştir. Cerrahi ve radyoterapi günümüzdeki başlıca tedavi yöntemleridir. Biz burada ONB saptanan 64 yaşındaki erkek olgunun X-ray grafi, B Mod-Doppler Ultrason (US) ve Bilgisayarlı Tomografi (BT) bulgularını sunduk.

Anahtar Kelimeler

• Olfaktör nöroblastoma, estesioblastoma, kribriform düzlem

References

1. Irish J, Dasgupa R, Freeman J, et al. Outcome and analysis of the surgical management of esthesioneu- roblastoma. J Otolaryng 1977; 26:1-7.
2. Becker L, Hinton D. Primitive neuroectodermal tumors of the central nervous system. Hum Pathol 1983; 14:538-550.
3. Broich G, Pagliari A, Ottaviani F. Esthesioneuroblas- toma: a general review of the cases published since the discovery of the tumour in 1924. Anticancer Res 1997;17:2683-2706.
4. Elkon D, Hightower SI, Lim ML et al. Esthesioneuro- blastoma. Cancer 1979;44:1087-1094.
5. Berger L, Luc G, Richard D. L´esthesioneuroepithelio meolfactif. Bull Assoc Franc Etude 1924; 13:410-421.
6. Stewart F, Frierson H, Levin P, Spaulding C. Esthesio- neuroblastoma. In Williams JG, Krikorian MR, Green D (eds.) Textbook of uncommon cancer. Oxford: Wiley and Sons, 1988:631-652.
7. Pickuth D, Heywang-Kobrunner H, Spielmann R. Com- puted tomography and magnetic resonance imaging features of olfactory neuroblastoma: an analysis of 22 cases. Clin Otolaryngol 1999; 24:457-461.
8. Biller HF, Lawson W, Sachdev VP, Som P. (1990) Es- thesioneuroblastoma: surgical treatment without ra- diation. Laryngoscope 1990; 100:1199-1201.

9. Shaari C, Catalano P, Sen C, Post K. Central nervous system metastases from esthesioneuroblastoma. Otolaryngol Head Neck Surg 1996; 114:808-812.
10. Beitler J, Fass D, Brenner H. Esthesioneuroblastoma: is there a role for elective neck treatment. Head Neck 1991; 13:321-326.