Side effects of sugammadex use in pediatric patients

Abstract

Objective: It is accepted that sugammadex show its effects more rapidly than the other neuromuscular block antagonists in many studies, however especially in pediatric cases, it is seen that about its reliability and side effects are limited in some studies. In our retrospective study, we aimed to present our experiences on sugammadex in terms of its side effects in the pediatric cases in our hospital for a 1-year period. Methods: The patient files and intraoperative anesthesia records, postoperative 24th hour and after postoperative 24th hour of the cases that underwent the application of sugammadex under general anesthesia in pediatric surgery operating room in a 1-year period were analyzed. Results: Totally 46 patients received sugammadex; infants (28 days-23 months) (n=24), children (2 years-11 years) (n=16) and adolescent (11-17 years) (n=6). None of the patients showed hypersensitivity and statistically significant side effects correlated to sugammadex. Conclusion: We think that sugammadex may open new doors in pediatric patient group with its features. However, more documentation is needed about the safety in pediatric patient group, particularly in infants. J Clin Exp Invest 2013; 4 (3): 265-268

Keywords

• Sugammadex, pediatric patient, side effect

Pediatrik hastalarda sugammadeks kullanımının yan etkileri

Öz

Amaç: Sugammadeks\'in diğer nöromuskuler blok antagonisti ajanlardan daha hızlı etki gösterdiği yapılan çalışmalarla kabul edilmektedir fakat özellikle pediatrik olgularda güvenilirlik, yan etkileri ile ilgili yapılan çalışmaların sınırlı olduğu görülmektedir. Kliniğimizdeki pediatrik olgularda bir yıllık süredeki sugammadeks deneyimlerimizin yan etkileri bakımından olgu serisi olarak sunulması amaçlanmıştır. Yöntemler: Bir yıllık sürede Tıp Fakültesi ameliyathanesi, çocuk cerrahisi odasında genel anestezi altında sugammadeks uygulanmış olguların dosyaları ve intraoperatif anestezi kayıtları, postoperatif 24 saat ve postoperatif 24 saat sonrası kayıtları incelendi. Bulgular: İnfant (28 gün- 23 ay) (n= 24), çocuk (2 yas- 11 yas) (n= 16), adolesan (11- 17 yas) (n=6) olmak üzere sugammadeks uygulanan toplam hasta sayısı 46 idi. Hastaların hiçbirisinde hipersensitivite bulgularına ve sugammadeks ile ilişkilendirilen istatistiksel anlamlı yan etkiye rastlanmadığı tespit edildi. Sonuç: Sugammadeks\'in sahip olduğu özellikleri ile pediatrik hasta grubunda yeni kapılar açabileceğini düşünmekteyiz. Fakat pediatrik hasta grubunda özellikle infantlarda güvenliği ile ilgili daha fazla dökümantasyona ihtiyaç vardır.

Anahtar Kelimeler

• Sugammadeks, pediatrik hasta, yan etki

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