The effects of typical and atypical antipsychotics on the electrical activity of the brain in a rat model

Abstract

Objective: Antipsychotic drugs are known to have strong effect on the bioelectric activity in the brain. However, some studies addressing the changes on electroencephalography (EEG) caused by typical and atypical antipsychotic drugs are conflicting. We aimed to compare the effects of typical and atypical antipsychotics on the electrical activity in the brain via EEG recordings in a rat model. Methods: Thirty-two Sprague Dawley adult male rats were used in the study. The rats were divided into five groups, randomly (n=7, for each group). The first group was used as control group and administered 1 ml/kg saline intraperitoneally (IP). Haloperidol (1 mg/kg) (group 2), chlorpromazine (5 mg/kg) (group 3), olanzapine (1 mg/kg) (group 4), ziprasidone (1 mg/ kg) (group 5) were injected IP for five consecutive days. Then, EEG recordings of each group were taken for 30 minutes. Results: The percentages of delta and theta waves in haloperidol, chlorpromazine, olanzapine and ziprasidone groups were found to have a highly significant difference compared with the saline administration group (p

Keywords

• Haloperidol, chlorpromazine, olanzapine, ziprasidone, EEG, rat

Rat modelinde tipik ve atipik antipsikotik ilaçların beyin elektriksel aktivitesi üzerine etkileri

Abstract

Amaç: Antipsikotik ilaçların beyinde güçlü biyoelektrik aktivite etkilerinin olduğu bilinmektedir. Fakat tipik ve atipik antipsikotik ilaçlara bağlı olan elektroensefalografi (EEG) değişikliklerinin karşılaştırmalı çalışmaları tartışmalıdır. Biz bir rat modelinde tipik ve atipik antipsikotik ilaçların beyinde elektriksel aktivitesi üzerine olan etkilerini EEG ile karşılaştırmayı amaçladık. Yöntemler: Bu çalışmada, 35 adet erişkin erkek Sprague Dawley cinsi rat kullanıldı. Herbiri 7 adet rat içeren 5 adet grup oluşturuldu. Birinci grup kontrol grubu olarak kullanıldı ve intraperitoneal yolla 1 ml/kg salin verildi. Beş gün boyunca intraperitoneal olarak haloperidol (1 mg/kg) (grup 2), klorpromazin (5 mg/kg) (grup 3), olanzapin (1 mg/kg) (grup 4) ve ziprasidon (1 mg/kg) (grup 5) verildi. Beşinci günün sonunda bütün grupların 30 dakika EEG kaydı alındı. Bulgular: Haloperidol, klorpromazin, olanzapin ve ziprasidon gruplarında delta ve teta dalga yüzdelerinin salin verilen gruba göre anlamlı düzeyde yüksek olduğu görüldü (p

Keywords

• Haloperidol, klorpromazin, olanzapin, ziprasidon, EEG, rat

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