Leukemoid reaction in a patient with acute lymphoblastic leukemia following the second chemotherapy

Abstract

The occurrence of persistent neutrophilic leukocy­tosis above 50,000 cells/μL for reasons other than leukemia is defined as leukemoid reaction. Chronic myelogenous leukemia (CML) and chronic neutro­philic leukemia (CNL) should be excluded, and un­derlying diseases or causes should be examined, in differential diagnosis. The most commonly ob­served causes of leukemoid reactions are severe infections, intoxications, malignancies, severe hem­orrhage, or acute hemolysis [1]. J Clin Exp Invest 2013; 4 (2): 258-259.

Keywords

• -

Akut lenfoblastik lösemili hastada ikinci kemoterapi sonrası gelişen lökomoid reaksiyon

Abstract

The occurrence of persistent neutrophilic leukocy­tosis above 50,000 cells/μL for reasons other than leukemia is defined as leukemoid reaction. Chronic myelogenous leukemia (CML) and chronic neutro­philic leukemia (CNL) should be excluded, and un­derlying diseases or causes should be examined, in differential diagnosis. The most commonly ob­served causes of leukemoid reactions are severe infections, intoxications, malignancies, severe hem­orrhage, or acute hemolysis [1].

Keywords

• -

References

1. Sakka V, Tsiodras S, Giamarellos-Bourboulis EJ, Gia- marellou H. An update on the etiology and diagnostic evaluation of a leukemoid reaction. Eur J Intern Med 2006;17:394-398.
2. Olipitz W, Strunk D, Beham-Schmid C, Sill H. Neutro- philic leukemoid reaction as the presenting feature of de novo and therapy-related acute leukemias. Acta Haematol 2004;111 :233-234.
3. Kaung DT. Leukemoid reaction in acute lymphoblastic leukemia: a response to chemotherapy. J Iowa Med Soc 1973;63:114-117.
4. Liu CZ, Persad R, Inghirami G, et al. Transient atypical monocytosis mimic acute myelomonocytic leukemia in post-chemotherapy patients receiving G-CSF: re- port of two cases. Clin Lab Haematol 2004;26:359- 362.
5. Schmid C, Frisch B, Beham A, et al. Comparison of bone marrow histology in early chronic granulocytic leukemia and in leukemoid reaction. Eur J Haematol 1990;44:154-158.
6. Florena AM, Franco V, Iannitto E, Salvato M. [Immuno- phenotyping of early-phase chronic myeloid leukemia and leukemoid reaction]. Pathologica 1994;86:384- 391.
7. Sun CY, Lin HC, Chen YC, et al. Leukemoid reaction after methotrexate-induced pancytopenia in a patient undergoing continuous ambulatory peritoneal dialy- sis. Chang Gung Med J 2006;29:513-517.
8. Mori H, Shibuya T, Osada T, et al. Response to che- motherapy in a case of gastric adenocarcinoma pro- ducing granulocyte colony-stimulating factor. Med Sci Monit 2010;16:CS119-123.