Adenoidal tissue expression of CD23: An evaluation with reference to recurrent upper respiratory tract complaints and allergy in children

Year 2013, , 1 - 7, 01.03.2013

Demet Alaygut Mehtat Unlu Semih Sutay Özkan Karaman Özden Anal

https://doi.org/10.5799/ahinjs.01.2013.01.0225

Abstract

Objective: In this study, CD23, low affinity immunoglobu­lin E receptor, expression in the adenoid tissue was inves­tigated immunohistochemically and evaluated with regard to upper respiratory tract infection complaints and allergy. Methods: This retrospective study was performed by the selection of 100 patients aged 2-13 years who underwent adenoidectomy/adenotonsillectomy and in whom the ad­enoid tissue pathological studies were reported as “lym­phoid hyperplasia and chronic infection” were evaluated. Immunohistochemical evaluation of CD23 expression was scored semiquantitatively between 0-3 in the tissue samples. Results: The mean age in the study group was 70.7 months; 46% were female; 30% of patients had adenoid­ectomy only. Following the operation, the infection fre­quency decreased in 91% of patients, whereas allergy symptoms were unchanged in 84%. CD23 expression was found significantly lower in patients who had allergic manifestations, namely urticaria (p=0.041), drug sensitiv­ity (p=0.035) and pollen allergy (p=0.037). Conclusion: A significantly reduced CD23 expression was found in adenoidal tissue in patients with allergic symptoms. These results can be assessed as an under­lying mechanism for the recurrence of respiratory tract complaints in these children, despite adenoidectomy. J Clin Exp Invest 2013; 4 (1): 1-7

Keywords

CD23 expression, adenoid tissue, atopy

Adenoid doku CD23 (FcεRII) ekspresyonu: Çocuklarda tekrarlayan üst solunum yolu enfeksiyonu yakınmaları ve allerji temelinde bir değerlendirme

Abstract

Amaç: Bu çalışmada, CD23, IgE\'nin düşük afiniteli resep­törü immunohistokimyasal yöntemle değerlendirildi ve üst solunum yolu enfeksiyonu ve alerji semptomlarının varlı­ğına göre analiz edildi. Yöntemler: Bu retrospektif çalışmaya yaşları 2-13 yaş arasında değişen adenoidekromi ve adenoidektomi/ ton­sillektomi operasyonu geçiren 100 hasta alındı. Patoloji raporları lenfoid hiperplazi ve kronik enfeksiyon şeklinde olanlar çalışmaya dahil edildi. Immunohistokimyasal ola­rak CD23 ekspresyonu semikantitatif metodla (0-3) ara­sında değerlendirildi. Bulgular: Çalışma grubunun ortalama yaşı 70,7 ay, % 46\'sı kız hastalardan oluşmaktaydı ve hastaların % 30\'u sadece adenoidektomi operasyonu geçirmişti. Operas­yon sonrası, enfeksiyon sıklığı % 91 oranında azalmakla birlikte, alerji semptomları %84 oranında değişmemişti. CD23 ekspresyonu özellikle ürtiker yakınması olanlarda (p=0,037), ilaç alerjisi olanlarda (p= 0.035) ve polen alerji­si (p= 0.041) olanlarda anlamlı olarak düşük bulundu. Sonuç: Atopik hastalarda adenoid dokuda CD23 yüzey ekspresyonunun azalacağı tezini destekler şekilde ürti­ker, ilaç allerjisi ve polen allerjisi olan hastalarda CD23 yoğunluğunu anlamlı olarak azalmış saptandı. Bu sonuç­lar, adenoidektomiye rağmen tekrarlayan solunum yolu semptomları olan çocuklarda altta yatan mekanizmayı açıklamak açısından değerlendirilebilir.

Keywords

CD23 ekspresyonu, adenoid doku, atopi

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