Is there a correlation between the size of the BCG scar and renal scar of urinary tract infections in children?

Abstract

Objective: Pyelonephritis cause cellular death, and de­velopment of scars in kidneys. The aim of this study is to demonstrate a correlation (if any) between renal scar, and size of the scar induced by BCG vaccine in children who had experienced urinary tract infections. In case of detec­tion of any correlation, BCG scar formation can be used as a determinative marker of renal scars, which develop following urinary tract infection. Methods: Patients with a history of urinary tract infection at least 4 months old who had undergone 99mTcDMSA scanning were included in this study. Vertical and hori­zontal diameters of BCG scars of the patients in the study group were measured. For statistical analysis the greatest diameter was taken into consideration, and the patients were divided into 2 subgroups based on the greatest di­ameter of their BCG scars (Subgroups 1, ≤5 mm, and 2, >5 mm). The patients were also evaluated in 2 groups as those with (Group 1) or without (Group 2) scars. Both groups were compared with subgroups with the largest scar diameters of ≤ 5mm or >5 mm Results: Study population included 108 (82 girls) pa­tients. DMSA detected scars in a total of 51 patients. Mean ages of the patients with and without scars were not different (p=0.414). No significant difference was found in size of the BCG scars between renal scar positive and negative groups (p>0.05). Conclusion: No correlation was found between develop­ment of renal scar and the size of BCG scar in children after urinary tract infection. J Clin Exp Invest 2013; 4 (1): 8-12

Keywords

• BCG scar, renal scar, urinary tract infection, children

Çocuklarda idrar yolu enfeksiyonu sonrası gelişen renal skar ile BCG skarı boyutu arasında bir ilişki var mıdır?

Abstract

Amaç: Pyelonefrit böbreklerde hücre ölümü ve skar geli­şimine neden olmaktadır. Bu çalışmanın amacı, idrar yolu enfeksiyonu geçiren çocuklarda oluşan renal skar ile BCG skar boyutu arasında herhangi bir korelasyon olup olma­dığını göstermektir. Bir korelasyon bulunması durumunda BCG skarı idrar yolu enfeksiyonu sonrası gelişen renal skarda belirleyici bir marker olarak kullanılabilecektir. Yöntemler: En az 4 ay önce idrar yolu enfeksiyonu geçir­miş, 99mTcDMSA sintigrafisi çekilmiş olan çocuk hastalar bu çalışmaya alındı Çalışma grubundaki hastaların BCG skarı vertikal ve horizontal çapta ölçüldü. İstatistiksel ana­liz için en büyük çap dikkate alındı ve ≤5 mm ve >5 mm olarak iki gruba ayrıldı. Hastalar renal skarı olanlar (Grup 1) ve renal skar geliştirmeyenler (Grup 2) olmak üzere iki grupta toplandı. Her iki grup, BCG skar boyutu ≤5 mm veya >5 mm olan gruplar ile karşılaştırıldı. Bulgular: 108 (82 kız) hasta çalışmaya dahil edildi. DM­SA\'da skar olan toplam 51 hasta vardı. Skarı olan ve ol­mayan hastaların ortalama yaşları farklı değildi. (p=0,414) Renal skar bulunan ve bulunmayan gruplar arasında BCG skar boyutu bakımından istatistiksel olarak anlamlı bir fark bulunmadı (p>0,05). Tartışma: İdrar yolu enfeksiyonu geçiren çocuklarda re­nal skar gelişimi ile BCG skar boyutu arasında bir kore­lasyon bulunmadı.

Keywords

• BCG skarı, renal skar, idrar yolu en­feksiyonu, çocuklar

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