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The relationship between microvascular complications and depression in patients with type 2 diabetes mellitus who use insulin

Year 2013, , 34 - 39, 01.03.2013
https://doi.org/10.5799/ahinjs.01.2013.01.0230

Abstract

Objective: This study aimed to assess the relationship between Type 2 Diabetes Mellitus (DM) and its complica­tions with the severity of depression. Methods: Eighty diabetics under the age of 65 using insulin were enrolled and clinical and biochemical data were recorded. The severity of neuropathy was deter­mined by the “United Kingdom neuropathy screening score” (UKNS) whereas the severity of depression was determined by the “Beck depression scale” (BDS). Ne­phropathy and retinopathy were assessed by the micro­albumin-creatinine ratio in spot urine samples and by de­tailed examination of the retina with an ophthalmoscope, respectively. Results: There were more patients who has high neurop­athy severity in the group with the highest Beck depres­sion scale score (p

References

  • Schellhase KG, Koepsell TD, Weiss NS. Glycemic control and the risk of multiple microvascular diabetic complications. Fam Med 2005;37:125-130.
  • Ma J, Yang W, Fang N, et al. The association between intensive glycemic control and vascular complica- tions in type 2 diabetes mellitus: a meta-analysis. Nutr Metab Cardiovasc Dis 2009;19:596-603.
  • Carney C. Diabetes mellitus and major depressive dis- order: an overview of prevalence, complications, and treatment. Depress Anxiety 1998;7:149–157.
  • Anderson RJ, Freedland KE, Clouse RE, et al. The prevalence of comorbid depression in adults with dia- betes: a meta-analysis. Diabetes Care 2001;24:1069- 1078
  • Lustman PJ, Griffith LS, Freedland KE, et al. Cogni- tive behavior therapy for depression in type 2 dia- betes: a randomized controlled trial. Ann Intern Med 1998;129:613-621.
  • Mazze RS, Lucido D, Shamoon H. Psychological and social correlates of glycemic control. Diabetes Care 1984;7:360-366.
  • Testa MA, Simonson DC. Health economic benefits and quality of life during improved glycemic con- trol in patients with type 2 diabetes mellitus. JAMA 1998;280:1490-1496.
  • Lin EH, Katon W, Von Korff M, et al. Relationship of depression and diabetes self-care, medication adherence, and preventive care. Diabetes Care 2004;27:2154–2160.
  • Georgiades A, Zucker N, Friedman KE, et al. Changes in depressive symptoms and glycemic control in dia- betes mellitus. Psychosom Med 2007;69:235-241.
  • Katon WJ. Clinical and health services relation- ships between major depression, depressive symp- toms, and general medical illness. Biol Psychiatry 2003;54:216-226.
  • Mezuk B, Eaton WW, Albrecht S, Golden SH. Depres- sion and type 2 diabetes over the lifespan: a meta- analysis. Diabetes Care 2008;31:2383-2390.
  • de Groot M, Anderson R, Freedland KE, Clouse RE, Lustman PJ. Association of depression and diabetes complications: a meta-analysis. Psychosomatic Med 2001;63:619-630.
  • Turkington RW. Depression masquerading as diabetic neuropathy. JAMA 1980;243:1147-1150.
  • Moreira RO, Amâncio AP, Brum HR, et al. Depressive symptoms and quality of life in type 2 diabetic patients with diabetic distal polyneuropathy. Arq Bras Endocri- nol Metabol 2009;53:1103-1111.
  • Vileikyte L, Leventhal H, Gonzalez JS, et al. Diabetic peripheral neuropathy and depressive symptoms: the association revisited. Diabetes Care 2005;28:2378- 2383.
  • Takahashi Y, Hirata Y. A follow-up study of painful dia- betic neuropathy: physical and psychological aspects. Tohoku J Exp Med 1983;141:463-471.
  • Oguejiofor OC, Oli JM, Ajaero CN, et al. Are the symp- toms of diabetic peripheral neuropathy in Nigerian pa- tients objective? An evaluation using the United King- dom Screening Test (UKST) and Bio-Thesiometry. Niger J Clin Pract 2009;12:113-119.
  • Gore M, Brandenburg NA, Dukes E, et al. Pain se- verity in diabetic peripheral neuropathy is associated with patient functioning, symptom levels of anxiety and depression, and sleep. J Pain Symptom Manage 2005;30:374-385.
  • Moreira RO, Papelbaum M, Fontenelle LF, et al. Co- morbidity of psychiatric disorders and symmetric dis- tal polyneuropathy among type II diabetic outpatients. Braz J Med Biol Res 2007;40:269-275.
  • Lehto SM, Hintikka J, Niskanen L, et al. Low HDL cholesterol associates with major depression in a sample with a 7-year history of depressive symp- toms. Prog Neuropsychopharmacol Biol Psychiatry 2008;32:1557-1561.
  • Lehto SM, Ruusunen A, Niskanen L, et al. Elevated depressive symptoms and compositional changes in LDL particles in middle-aged men. Eur J Epidemiol 2010;25:403-409.
  • Tyrovolas S, Lionis C, Zeimbekis A, et al. Increased body mass and depressive symptomatology are as- sociated with hypercholesterolemia, among elderly in- dividuals; results from the MEDIS study. Lipids Health Dis 2009; 8:10-11.
  • Heckbert SR, Rutter CM, Oliver M, et al. Depression in relation to long-term control of glycemia, blood pressure, and lipids in patients with diabetes. J Gen Intern Med 2010;25:524-529.
  • Gary TL, Crum RM, Cooper-Patrick L, et al. Depres- sive symptoms and metabolic control in African-Amer- icans with type 2 diabetes. Diabetes Care 2000;23:23- 29.
  • Katon WJ, Lin EH, Russo J, et al. Cardiac risk factors in patients with diabetes mellitus and major depres- sion. J Gen Intern Med 2004;19:1192-1199.
  • Wiggin TD, Sullivan KA, Pop-Busui R, et al. Elevated triglycerides correlate with progression of diabetic neuropathy. Diabetes 2009;58:1634-1640.
  • Vincent AM, Edwards JL, Sadidi M, et al. The antioxi- dant response as a drug target in diabetic neuropathy. Curr Drug Targets 2008;9:94-100.
  • Vincent AM, Hinder LM, Pop-Busui R, et al. Hyperlip- demia: A new therapeutic target for diabetic neuropa- thy. J of Periph Nerv Syst 2009;14:257-267.

İnsülin kullanan tip 2 diabetes mellitus hastalarında mikrovasküler komplikasyonlar ile depresyonun ilişkisi

Year 2013, , 34 - 39, 01.03.2013
https://doi.org/10.5799/ahinjs.01.2013.01.0230

Abstract

Amaç: Bu çalışmada kronik bir hastalık olan Tip 2 Dia­betes Mellitus (DM) ve komplikasyonlarının depresyon şiddeti ile ilişkisi değerlendirilmesi amaçlandı. Yöntemler: Çalışmaya 65 yaşından küçük, insülin kullan­makta olan 80 Tip 2 DM hastası alınarak klinik ve biyokim­yasal verileri kaydedildi. Nöropati şiddeti “United Kingdom nöropati tarama skoru” (UKNS) ile, depresyon şiddeti ise “Beck Depresyon Envanteri” (BDE) ile belirlendi. Nefro­pati spot idrar örneğinde mikroalbumin-kreatinin oranı ile, retinopati ise göz dibi muayenesi ile değerlendirildi. Bulgular: Beck depresyon şiddeti yüksek olan hasta gru­bu içindeki nöropati şiddeti yüksek olan hasta sayısı daha fazlaydı (p

References

  • Schellhase KG, Koepsell TD, Weiss NS. Glycemic control and the risk of multiple microvascular diabetic complications. Fam Med 2005;37:125-130.
  • Ma J, Yang W, Fang N, et al. The association between intensive glycemic control and vascular complica- tions in type 2 diabetes mellitus: a meta-analysis. Nutr Metab Cardiovasc Dis 2009;19:596-603.
  • Carney C. Diabetes mellitus and major depressive dis- order: an overview of prevalence, complications, and treatment. Depress Anxiety 1998;7:149–157.
  • Anderson RJ, Freedland KE, Clouse RE, et al. The prevalence of comorbid depression in adults with dia- betes: a meta-analysis. Diabetes Care 2001;24:1069- 1078
  • Lustman PJ, Griffith LS, Freedland KE, et al. Cogni- tive behavior therapy for depression in type 2 dia- betes: a randomized controlled trial. Ann Intern Med 1998;129:613-621.
  • Mazze RS, Lucido D, Shamoon H. Psychological and social correlates of glycemic control. Diabetes Care 1984;7:360-366.
  • Testa MA, Simonson DC. Health economic benefits and quality of life during improved glycemic con- trol in patients with type 2 diabetes mellitus. JAMA 1998;280:1490-1496.
  • Lin EH, Katon W, Von Korff M, et al. Relationship of depression and diabetes self-care, medication adherence, and preventive care. Diabetes Care 2004;27:2154–2160.
  • Georgiades A, Zucker N, Friedman KE, et al. Changes in depressive symptoms and glycemic control in dia- betes mellitus. Psychosom Med 2007;69:235-241.
  • Katon WJ. Clinical and health services relation- ships between major depression, depressive symp- toms, and general medical illness. Biol Psychiatry 2003;54:216-226.
  • Mezuk B, Eaton WW, Albrecht S, Golden SH. Depres- sion and type 2 diabetes over the lifespan: a meta- analysis. Diabetes Care 2008;31:2383-2390.
  • de Groot M, Anderson R, Freedland KE, Clouse RE, Lustman PJ. Association of depression and diabetes complications: a meta-analysis. Psychosomatic Med 2001;63:619-630.
  • Turkington RW. Depression masquerading as diabetic neuropathy. JAMA 1980;243:1147-1150.
  • Moreira RO, Amâncio AP, Brum HR, et al. Depressive symptoms and quality of life in type 2 diabetic patients with diabetic distal polyneuropathy. Arq Bras Endocri- nol Metabol 2009;53:1103-1111.
  • Vileikyte L, Leventhal H, Gonzalez JS, et al. Diabetic peripheral neuropathy and depressive symptoms: the association revisited. Diabetes Care 2005;28:2378- 2383.
  • Takahashi Y, Hirata Y. A follow-up study of painful dia- betic neuropathy: physical and psychological aspects. Tohoku J Exp Med 1983;141:463-471.
  • Oguejiofor OC, Oli JM, Ajaero CN, et al. Are the symp- toms of diabetic peripheral neuropathy in Nigerian pa- tients objective? An evaluation using the United King- dom Screening Test (UKST) and Bio-Thesiometry. Niger J Clin Pract 2009;12:113-119.
  • Gore M, Brandenburg NA, Dukes E, et al. Pain se- verity in diabetic peripheral neuropathy is associated with patient functioning, symptom levels of anxiety and depression, and sleep. J Pain Symptom Manage 2005;30:374-385.
  • Moreira RO, Papelbaum M, Fontenelle LF, et al. Co- morbidity of psychiatric disorders and symmetric dis- tal polyneuropathy among type II diabetic outpatients. Braz J Med Biol Res 2007;40:269-275.
  • Lehto SM, Hintikka J, Niskanen L, et al. Low HDL cholesterol associates with major depression in a sample with a 7-year history of depressive symp- toms. Prog Neuropsychopharmacol Biol Psychiatry 2008;32:1557-1561.
  • Lehto SM, Ruusunen A, Niskanen L, et al. Elevated depressive symptoms and compositional changes in LDL particles in middle-aged men. Eur J Epidemiol 2010;25:403-409.
  • Tyrovolas S, Lionis C, Zeimbekis A, et al. Increased body mass and depressive symptomatology are as- sociated with hypercholesterolemia, among elderly in- dividuals; results from the MEDIS study. Lipids Health Dis 2009; 8:10-11.
  • Heckbert SR, Rutter CM, Oliver M, et al. Depression in relation to long-term control of glycemia, blood pressure, and lipids in patients with diabetes. J Gen Intern Med 2010;25:524-529.
  • Gary TL, Crum RM, Cooper-Patrick L, et al. Depres- sive symptoms and metabolic control in African-Amer- icans with type 2 diabetes. Diabetes Care 2000;23:23- 29.
  • Katon WJ, Lin EH, Russo J, et al. Cardiac risk factors in patients with diabetes mellitus and major depres- sion. J Gen Intern Med 2004;19:1192-1199.
  • Wiggin TD, Sullivan KA, Pop-Busui R, et al. Elevated triglycerides correlate with progression of diabetic neuropathy. Diabetes 2009;58:1634-1640.
  • Vincent AM, Edwards JL, Sadidi M, et al. The antioxi- dant response as a drug target in diabetic neuropathy. Curr Drug Targets 2008;9:94-100.
  • Vincent AM, Hinder LM, Pop-Busui R, et al. Hyperlip- demia: A new therapeutic target for diabetic neuropa- thy. J of Periph Nerv Syst 2009;14:257-267.
There are 28 citations in total.

Details

Primary Language Turkish
Journal Section Research Article
Authors

Mehmet Ali Eren This is me

Ayşe Nur Torun This is me

Suzan Tabur This is me

Muharrem İngeç This is me

Mehmet Demir This is me

Tevfik Sabuncu This is me

İbrahim Fatih Karababa This is me

Publication Date March 1, 2013
Published in Issue Year 2013

Cite

APA Eren, M. A., Torun, A. N., Tabur, S., İngeç, M., et al. (2013). İnsülin kullanan tip 2 diabetes mellitus hastalarında mikrovasküler komplikasyonlar ile depresyonun ilişkisi. Journal of Clinical and Experimental Investigations, 4(1), 34-39. https://doi.org/10.5799/ahinjs.01.2013.01.0230
AMA Eren MA, Torun AN, Tabur S, İngeç M, Demir M, Sabuncu T, Karababa İF. İnsülin kullanan tip 2 diabetes mellitus hastalarında mikrovasküler komplikasyonlar ile depresyonun ilişkisi. J Clin Exp Invest. March 2013;4(1):34-39. doi:10.5799/ahinjs.01.2013.01.0230
Chicago Eren, Mehmet Ali, Ayşe Nur Torun, Suzan Tabur, Muharrem İngeç, Mehmet Demir, Tevfik Sabuncu, and İbrahim Fatih Karababa. “İnsülin Kullanan Tip 2 Diabetes Mellitus hastalarında mikrovasküler Komplikasyonlar Ile Depresyonun ilişkisi”. Journal of Clinical and Experimental Investigations 4, no. 1 (March 2013): 34-39. https://doi.org/10.5799/ahinjs.01.2013.01.0230.
EndNote Eren MA, Torun AN, Tabur S, İngeç M, Demir M, Sabuncu T, Karababa İF (March 1, 2013) İnsülin kullanan tip 2 diabetes mellitus hastalarında mikrovasküler komplikasyonlar ile depresyonun ilişkisi. Journal of Clinical and Experimental Investigations 4 1 34–39.
IEEE M. A. Eren, “İnsülin kullanan tip 2 diabetes mellitus hastalarında mikrovasküler komplikasyonlar ile depresyonun ilişkisi”, J Clin Exp Invest, vol. 4, no. 1, pp. 34–39, 2013, doi: 10.5799/ahinjs.01.2013.01.0230.
ISNAD Eren, Mehmet Ali et al. “İnsülin Kullanan Tip 2 Diabetes Mellitus hastalarında mikrovasküler Komplikasyonlar Ile Depresyonun ilişkisi”. Journal of Clinical and Experimental Investigations 4/1 (March 2013), 34-39. https://doi.org/10.5799/ahinjs.01.2013.01.0230.
JAMA Eren MA, Torun AN, Tabur S, İngeç M, Demir M, Sabuncu T, Karababa İF. İnsülin kullanan tip 2 diabetes mellitus hastalarında mikrovasküler komplikasyonlar ile depresyonun ilişkisi. J Clin Exp Invest. 2013;4:34–39.
MLA Eren, Mehmet Ali et al. “İnsülin Kullanan Tip 2 Diabetes Mellitus hastalarında mikrovasküler Komplikasyonlar Ile Depresyonun ilişkisi”. Journal of Clinical and Experimental Investigations, vol. 4, no. 1, 2013, pp. 34-39, doi:10.5799/ahinjs.01.2013.01.0230.
Vancouver Eren MA, Torun AN, Tabur S, İngeç M, Demir M, Sabuncu T, Karababa İF. İnsülin kullanan tip 2 diabetes mellitus hastalarında mikrovasküler komplikasyonlar ile depresyonun ilişkisi. J Clin Exp Invest. 2013;4(1):34-9.