Relationship between the severity of mitral regurgitation, left ventricular dysfunction and plasma brain natriuretic peptide level: An observational strain imaging study

Abstract

Keywords

• -

Relationship between the severity of mitral regurgitation, left ventricular dysfunction and plasma brain natriuretic peptide level: An observational strain imaging study

Öz

Amaç: Bu çalışmada mitral yetersizliği ve strain/strain rate (S/SR) ekokardiyografi ile tespit edilen sol ventrikül disfonksiyonunun derecesi ile plazma beyin natriüretik peptid seviyesi arasındaki ilişkinin araştırılması amaçlanmıştır.Gereç ve yöntem: Mevcut çalışma kesitsel, gözlemsel bir çalışmadır. Bu çalışmaya polikliniğimize başvurmuş olan ardışık 31 mitral yetersizliği hastası (15’i [%48,4] erkek) ve kontrol grubu olarak 25 sağlıklı birey (12’si [%48,0] erkek) alınmıştır. Hastalar orta derecede mitral yetmezliği olanlar (n=14 [%45,2] ve ileri derecede mitral yetmezliği olanlar (n=17 [%54,8] olarak iki gruba ayrılmışlar ve üç grupta sol ventrikül duvar segmentlerinin maksimum strain / strain rate ölçümleri kaydedilmiş, plazma beyin natriüretik peptit seviyeleri ölçülmüştür.Bulgular: İleri MY olan hastalarda orta MY ve kontrol grubu ile karşılaştırıldığında ileri MY grubunda sol ventrikül segment S/SR değerlerinde daha belirgin azalma izlendi (p

Anahtar Kelimeler

• Strain/strain rate, ekokardiyografi, mitral yetersizliği, sol ventrikül fonksiyonları

References

1. Singh JP, Evans JC, Levy D, et al. Prevalence and clini- cal determinants of mitral, tricuspid, and aortic regur- gitation (the Framingham Heart Study). Am J Cardiol 1999;83(7):897-902.
2. Lee R, Marwick TH. Assessment of subclinical left ven- tricular dysfunction in asymptomatic mitral regurgita- tion. Eur J Echocardiogr 2007;8(1): 175 -84.
3. Pelerin D, Sharma R, Elliott P, Veyrat C. Tissue Dop- pler, strain, and strain rate echocardiography for the assessment of left and right systolic ventricular func- tion. Heart 2003; Suppl 3: 9-17.
4. Sayar N, Lütfullah Orhan A, Cakmak N, et al. Correla- tion of the myocardial performance index with plasma B-type natriuretic peptide levels in patients with mitral regurgitation. Int J Cardiovasc Imaging 2008;24(1): 151-7.
5. Marciniak A, Claus P, Sutherland GR, et al. Changes in systolic left ventricular function in isolated mitral re- gurgitation. A strain rate imaging study. Eur Heart J 2007; 28(21):2627-36.
6. Kim MS, Kim YJ, Kim HK, et al. Evaluation of left ven- tricular short- and long-axis function in severe mitral regurgitation using 2-dimensional strain echocardiog- raphy. Am Heart J 2009;157(2):345-51.
7. Dagdelen S, Yuce M, Ergelen M, Pala S, Kirma C. Quantitation of papillary muscle function with tissue and strain Doppler echocardiography measures pap- illary muscle contractile functions. Echocardiography 2003; 20(1): 137- 44.
8. Sutton TM, Stewart RA, Gerber IL, et al. Plasma natri- uretic peptide levels increase with symptoms and se- verity of mitral regurgitation. J Am Coll Cardiol 2003: 18;41(18): 2280-7.

9. Bonow RO, Carabello BA, Kanu C, et al. Guidelines for the Management of Patients With Valvular Heart Disease:A Report of the American Heart Associa- tion Task Force on Practice guidelines. Circulation 2006;114(3):450-527.
10. Leopoldo P, Alberto dA, Jose Luis Rodrigo JL, et al. Chronic Mitral Regurgitation: A Pilot Study to Assess Preoperative Left Ventricular Contractile Function Us- ing Speckle-Tracking Echocardiography. J Am Soc Echocardiogr 2009; 22(6): 831-8.
11. Weidemann F, Jamal F, Sutherland GR, et al. Myo- cardial function defined by strain rate and strain dur- ing alterations in inotropic states and heart rate. Am J Physiol Heart Circ Physiol 2002; 283(6): 792-9.
12. Lee R, Hanekom L, Marwick TH, Leano R, Wahi S. Prediction of subclinical left ventricular dysfunc- tion with strain rate imaging in patients with asymp- tomatic severe mitral regurgitation. Am J Cardiol 2004;15;94(10):1333-7.
13. Koyama J, Ray-Sequin PA, Falk RH. Longitudinal myocardial function assessed by tissue velocity, strain and strain rate tissue Doppler echocardiography in patients with AL (primary) cardiac amyloidosis. Circu- lation 2003;107(16):2446 -52.
14. Palka P, Lange A, Fleming AD, et al. Differences in myocardial velocity gradient measured throughout the cardiac cycle in patients with hypertrophic cardio- myopathy, athletes and patients with left ventricular hypertrophy due to hypertension. J Am Coll Cardiol 1997;30(6):760-8.
15. Yurdakul S, Tayyareci Y, Yildirimturk O, Memic K, Aytekin V, Aytekin S. Subclinical left ventricular dys- function in asymptomatic chronic mitral regurgitation patients with normal ejection fraction: a combined tis- sue Doppler and velocity vector imaging-based study. Echocardiography 2011;28(8):877-85.