The relationship between biochemical parameters, interleukin-6 and ovarian morphology in polycystic ovary syndrome

Abstract

Objectives: The aim of this study is to investigate relationships between biochemical parameters and interleukin-6 according to the ovarian morphology in polycystic ovary syndrome (PCOS). Materials and methods: A total of 85 patients with PCOS were divided into three groups according to the ultrasonographic examination of the ovaries; group 1 (with no polycystic image at any of the ovaries, n=22), group 2 (with polycystic image at only one ovary, n=41), and group 3 (with polycystic image at both of the ovaries, n=22). Serum interleukin 6 (IL-6), hormone levels, and homeostasis model assessment-insulin resistance (HOMA-IR) were measured. Results: The mean serum IL-6 levels for groups 1, 2 and 3 were 14.65 ± 6.18 pg/mL, 16.22 ± 6.55 pg/mL, and 14:53 ± 7.32 pg/mL, respectively. There was no statically difference between three groups for serum IL-6 levels (p>0.05). For metabolic profile, the mean of HOMA-IR was 3.09±1.56 for group 2 and this was significantly lower than other groups (p

Keywords

• PCOS, interleukin-6, ovarian morphology.

The relationship between biochemical parameters, interleukin-6 and ovarian morphology in polycystic ovary syndrome

Öz

Amaç: Bu çalışmanın amacı polikistik over sendromunda (PKOS) biyokimyasal parametreler ve interleukin-6 ile over morfolojisi ilişkisini değerlendirmektir. Gereç ve yöntem: PKOS tanısı almış 85 hasta overlerin ultrasonografik değerlendirmesine göre; grup 1 ( polikistik görünümü olmayan, n = 22), grup 2 (bir overde polikistik görüntüsü olan, n = 41) ve grup 3 (her iki overde polikistik görüntüsü olan, n = 22) olmak üzere üç gruba ayrıldı. Hastaların serum interlökin 6 (IL-6), hormone düzeyleri ve homeostasis model assessment-insulin rezistans (HOMA-IR) değerleri ölçüldü. Bulgular: Serum IL-6 seviyeleri değerlendirildiğinde, ortalama değerler gruplar için sırasıyla 14.65±6.18 pg/mL, 16.22±6.55 pg/mL ve 14.53±7.32 pg/mL olarak bulundu. Serum IL-6 düzeyleri için üç grup arasında istatistiksel olarak anlamlı bir fark yoktu (p> 0.05). Metabolik profiling değerlendirmesinde ise HOMA-IR değeri grup 2 de 3,09±1,56 bulundu ve diğer gruplara göre anlamlı düzeyde düşüktü (p

Anahtar Kelimeler

• PKOS, interlökin-6, over morfolojisi

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