Serum S100B levels in patients with obstructive sleep apnea syndrome

Abstract

Objectives: Obstructive sleep apnea syndrome (OSAS) which is characterized by recurrent pharyngeal narrowing and breathing disturbances, can affect central neural system (CNS). S100B, which exerts neurotrophic and gliotrophic features, is a calcium binding protein. The aim of this study was to evaluate serum levels of S100B in patients with OSAS. Materials and methods: Clinical and laboratory assessment were performed in 26 patients (5 women and 21 men) with OSAS and 28 (8 women and 20 men) age-, body mass index (BMI)- and sex- matched healthy subjects served as controls . The patients included in the study had whole-night polysomnography (PSG) performed in the sleep laboratory. Measurements of S100B were done using the commercially available ELISA kit. Results: Patients and controls were well matched with regard to demographic characteristics. Serum S100B concentrations were 149.4±84.5 ng/L and 139.2±70.7 ng/L for patients with OSAS and control subject, respectively. There was no statistically significant difference in serum S100B concentrations between OSAS and control groups (p>0.05). Conclusions: Serum S100B protein level in serum did not significantly higher in patients with OSAS compared to the healthy subjects. However, further investigations are required, particularly in the area of biochemical markers of mild cerebral damage in patients with OSAS.

Keywords

• Obstructive sleep apnea syndrome, serum S100B, brain, polysomnography

Tıkayıcı uyku apne sendromlu hastalarda serum S100B düzeyleri

Öz

Amaç: Tekrarlayan faringeal daralmalar ve nefes almada zorlukla karakterize olan obstrüktif uyku apne sendromu (OSAS) santral sinir sistemini etkileyebilir. Nörotrofik ve gliotrofik özellikler gösteren S100B kalsiyum bağlayıcı bir proteindir. Bu çalışmanın amacı, OSAS bulunan hastalarda serum S100B\'nin düzeylerini araştırmaktır. Gereç ve yöntem: Klinik ve laboratuvar değerlendirmeler için OSAS\'lı 26 hasta (5 kadın ve 21 erkek)\' çalışmaya dahil edildi. Yaş, cinsiyet ve vücut kitle indeksi uygun 28 (8 kadın ve 20 erkek) sağlıklı gönüllü kontrol grubu olarak alındı. Hastalara uyku laboratuvarında tüm gece polisomnografi uygulandı. Serum S100B ölçümü ticari bir ELISA kiti kullanılarak yapıldı. Bulgular: Hasta ve sağlıklılar demografik özellikleri bakımından birbirleriyle uyumluydu. Serum S100B konsantrasyonları hastalar ve sağlıklı bireyler için sırasıyla, 149.4±84.5 ng/L ve 139.2±70.7 ng/L olarak bulundu. Obstrüktif uyku apne sendromu ve kontrol grubu arasında S100 B konsantrasyonlar bakımından anlamlı farklılık yoktu (p>0.05). Sonuç: Serum S100B protein düzeyinde OSAS\'lı hastalar kontrol grubu ile karşılaştırıldığında anlamlı fark bulunmadı. Daha sonraki çalışmalarla, OSAS\'lı hastalarda özellikle küçük serebral hasarı gösteren biyokimyasal belirteçler alanında yapılacak ileri araştırmalara ihtiyaç vardır.

Anahtar Kelimeler

• Tıkayıcı uyku apne sendromu, serum S100B, beyin, polisomnografi

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