Multifocal tumorlets and a carcinoid tumor associated with bronchiectasis

Abstract

Pulmonary tumorlet is multifocal neuroendocrine cell proliferation believed to be precursor lesion to pulmonary carcinoids. A 52-year-woman underwent a left lower lobectomy and lingulectomy for bronchiectasis. Histopathologically, multiple tumorlets and a carcinoid tumor were detected in the surgical specimen. J Clin Exp Invest 2012; 3(2): 273-276

Keywords

• Bronchiectasia, tumorlets, carcinoid tumor

Bronşektazi zemininde gelişen multiple tümörlet ve karsinoid tümör

Öz

Pulmoner tümörlet, multifokal nöroendokrin hücre proliferasyonudur ve pulmoner karsinoidler için prekürsör lezyon olarak kabul edilir. Bu çalışmada, 52 yaşında bronşektazi nedeniyle sol alt lobektomi ve lingulektomi yapılan bir hasta tartışıldı. Cerrahi spesmenin histopatolojik değerlendirmesinde bronşektatik zeminde multiple tümörlet ve karsinoid tümör saptandı.

Anahtar Kelimeler

• Bronşektazi, tümörletler, karsinoid tümör

References

1. Kerr KM. Pulmonary preinvasive neoplasia. J Clin Pathol 2001;54(2):257-71.
2. Armas OA, White DA, Erlandson RA, Rosai J. Diffuse idiopathic pulmonary neuroendcrine cell proliferation presenting as interstitial lung disease. Am J Surg Pathol 1995;19(8):963-70. Dewan M, Malatani TS, Osinowo O, Al-Nour M, Zahrani ME. Lessons to be learned: a case study approach carsinoid tumorlets associated with diffuse bronchiectasis and intralobar sequestration. J R Soc Promot Health 2000;120(2):192-5.
3. Churg A, Warnock ML. Pulmonary tumorlet: A form of peripheral carcinoid. Cancer 1976;37(10):1469-77.
4. Aguayo SM, Miller YE, Waldron JA, et al. Brief report: Idiopathic diffuse hyperplasia of pulmonary neuroendocrine cells and airways disease. N Eng J Med 1992;327(11):1285-8.
5. Garcia-Yuste M, Matilla JM, Alvarez-Gago T, and Spanish Multicenter Study of Neuroendocrine Tumors of the Lung of the Spanish Society of Pneumonology and Thoracic Surgery (EMETNE-SEPAR). Prognostic factors in neuroendocrine lung tumors: a Spanish Multicenter Study. Ann Thorac Surg 2000;70(2):258-63.
6. Cardillo G, Sera F, Di Martino M, et al. Bronchial carcinoid tumors: nodal status and long-term survival after resection. Ann Thorac Surg 2004;77(12):1781-5.
7. Demirağ F, Altınok T. Pulmonary and peribronchial lymph node tumorlets: report of a case and review of the literature. Tumori 2003;89(4):455-57.
8. D’Agati VD, Perzin KH. Carcinoid tumorlets of the lung with metastasis to a peribronchial lymph node: Report of a case and review of the literature. Cancer 1985;55(12):2472-6.

9. Ferguson MK, Landreneau RJ, Hazelrigg SR, et al. Long-term outcome after resection for bronchial carcinoid tumors. Eur J Cardiothorac Surg 2000;18(1):156-61.