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Serum paraoxanase-1 activity in patients with acute otitis media

Year 2011, , 412 - 415, 01.12.2011
https://doi.org/10.5799/ahinjs.01.2011.04.0083

Abstract

Amaç: Paraoksonaz (PON) yüksek dansiteli lipoprotein (HDL) ile ilişkili antioksidan bir enzimdir. Bu çalışmada akut otitis media (AOM) hastaları ile sağlıklı kontrol grubu arasında PON 1 aktivitesini karşılaştırmak amaçlanmaktadır. Gereç ve yöntem: AOM hastalarında prospektif, kontrollü bir çalışma yaptık. Çalışmaya 30 AOM hastası (17 erkek; yaş, 15 ± 9 yıl) ve 30 kontrol grubu (16 erkek; yaş, 16 ± 5) olmak üzere 60 birey dahil edildi. Hasta ve kontrol grubunda Mackness\'in metodu ile PON 1 aktivitesi ölçüldü. Bulgular: Akut otitis media hasta grubunda, kontrol grubuna göre PON 1 aktivitesi düşük düzeyde idi (155 ± 95 U/L ve 210 ± 96 U/L, P=0.04). Sonuç: Akut otitis media\'da oksidatif stres oluşmaktadır. Oluşan oksidatif hasarı önlemek amacıyla PON 1 enzimi daha fazla tüketilmektedir. Bu nedenle AOM hastalarında bu enzim aktivitesi düşük düzeyde elde edilmektedir.

References

  • Pukander J, Sipila M, Kataja M, Karma P. Estimating the risk of acute otitis media among urban children. Ann Otol Rhinol Laryngol 1990;149(3):18-20.
  • Serafini M, Del Rio D. Understanding the association between dietary antioxidants, redox status, and dis- ease: is the total antioxidant capacity the right tool? Redox Report 2004;9(3):145-52.
  • Seidman MD, Ahmad N, Joshi D, Seidman J, Thawani S, Quirk WS. Age-related hearing loss and its associ- ation with reactive oxygen species and mitochondrial DNA damage. Acta Otolaryngol Suppl 2004;(552):16- 24.
  • Doğru H, Delibaş N, Döner F, Tuz M, Uygur K. Free radical damage in nasal polyp tissue. Otolaryngol Head Neck Surg 2001;124(5):570-2.
  • Parks RR, Huang CC, Haddad J Jr. Evidence of oxy- gen radical injury in experimental otitis media. Laryn- goscope 1994;104(11):1389-92.
  • Rasheed MH, Beevi SS, Geetha A. Enhanced lipid per- oxidation and nitric oxide products with deranged anti- oxidant status in patients with head and neck squamous cell carcinoma. Oral Oncol 2007;43(4):333-8.
  • Tissié G, Guillermet V, Latour E, Coquelet C, Bonne C. Oxidative stress and lens opacity: an overall approach to screening anticataractous drugs. Ophthalmic Res 1988;20(1):27-30.
  • Diaz MN, Frei B, Vita JA, Keaney JF. Antioxidants and atherosclerotic heart disease. N Engl J Med 1997;337(6):408-16.
  • Wickens D, Wilkins MH, Lunec J, Ball G, Dormandy TL. Free radical oxidation (peroxidation) products in se- rum and synovial fluid in rheumatoid arthritis. J Rheu- matol 1981;8(2):233-45.
  • Machlin LJ, Bendich A. Free radical tissue damage: protective role of antioxidant nutrients. FASEB J 1987;1(6):441-5.
  • Lipincott W. Paraoxonase a cadioprotective en- zyme: continuing issuess. Curr Opin Lipidol 2004;15(3):261-7.
  • Mackness MI, Arrol S, Durrington PN. Paraoxonase prevents accumulation of lipoperoxides in low-density lipoprotein. FEBS Lett 1991;286(1-2):152-4.
  • Haliwell B. Reactive oxygen species in living system: Source biochemistry, and role in human disease. Am J Med 1991(3);91:149-235.
  • Takoudes TG, Haddad J Jr. Lipid peroxides in middle ear fluid after acute otitis media in guinea pigs. Otol Rhinol Laryngol 1999;108(6):564-8.
  • Bodolay E, Seres I, Szodoray P, et al. Evaluation of paraoxonase activity in patients with mixed connec- tive tissue disease. J Rheumatol 2008;35(2):237-43.
  • Selek S, Cosar N, Kocyigit A, et al. PON1 activity and total oxidant status in patients with active pulmonary tuberculosis. Clin Biochem 2008;41(3):140-4.
  • Isik A, Koca SS, Ustundag B, Selek S. Decreased total antioxidant response and increased oxida- tive stress in Behcet’s disease. Tohoku J Exp Med 2007;212(2):133-41.
  • Aslan M, Kosecik M, Horoz M, Selek S, Celik H, Erel O. Assessment of paraoxonase and arylesterase ac- tivities in patients with iron deficiency anemia. Athero- sclerosis 2007; 191(2): 397-402.
  • Emin T, Elkiran N. Serum paraoxonase and ary- lesterase activities in patients with lung cancer in a Turkish population. BMC Cancer 2007;7:48-52.

Serum paraoxanase-1 activity in patients with acute otitis media

Year 2011, , 412 - 415, 01.12.2011
https://doi.org/10.5799/ahinjs.01.2011.04.0083

Abstract

Objectives: Paraoxonase is a high-density lipoprotein (HDL)-associated antioxidant enzyme. We aimed to compare the activity of serum paraoxanase-1 (PON 1) in healthy controls and patients with acute otitis media (AOM). Subjects and methods: We performed a prospective controlled trial in patients with AOM. A total of 60 subjects, 30 patients with AOM (17 male; age, 15 ± 9 years) and 30 age- and sex-matched controls (16 male; age, 16 ± 5 years) were enrolled in this study. PON 1 activity was measured using Mackness\' methods. Results: PON 1 activity was significantly lower in the AOM group compared to control group (155 ± 95 U/L vs. 210 ± 96 U/L, P=0.04). Conclusions: The present study demostrates that serum PON 1 activity is low in AOM, similar to other conditions with increased oxidative stress. We speculate that PON 1 enzyme is consumed at a greater rate during AOM in order to prevent increased oxidative damage. J Clin Exp Invest 2011; 2 (4): 412-415

References

  • Pukander J, Sipila M, Kataja M, Karma P. Estimating the risk of acute otitis media among urban children. Ann Otol Rhinol Laryngol 1990;149(3):18-20.
  • Serafini M, Del Rio D. Understanding the association between dietary antioxidants, redox status, and dis- ease: is the total antioxidant capacity the right tool? Redox Report 2004;9(3):145-52.
  • Seidman MD, Ahmad N, Joshi D, Seidman J, Thawani S, Quirk WS. Age-related hearing loss and its associ- ation with reactive oxygen species and mitochondrial DNA damage. Acta Otolaryngol Suppl 2004;(552):16- 24.
  • Doğru H, Delibaş N, Döner F, Tuz M, Uygur K. Free radical damage in nasal polyp tissue. Otolaryngol Head Neck Surg 2001;124(5):570-2.
  • Parks RR, Huang CC, Haddad J Jr. Evidence of oxy- gen radical injury in experimental otitis media. Laryn- goscope 1994;104(11):1389-92.
  • Rasheed MH, Beevi SS, Geetha A. Enhanced lipid per- oxidation and nitric oxide products with deranged anti- oxidant status in patients with head and neck squamous cell carcinoma. Oral Oncol 2007;43(4):333-8.
  • Tissié G, Guillermet V, Latour E, Coquelet C, Bonne C. Oxidative stress and lens opacity: an overall approach to screening anticataractous drugs. Ophthalmic Res 1988;20(1):27-30.
  • Diaz MN, Frei B, Vita JA, Keaney JF. Antioxidants and atherosclerotic heart disease. N Engl J Med 1997;337(6):408-16.
  • Wickens D, Wilkins MH, Lunec J, Ball G, Dormandy TL. Free radical oxidation (peroxidation) products in se- rum and synovial fluid in rheumatoid arthritis. J Rheu- matol 1981;8(2):233-45.
  • Machlin LJ, Bendich A. Free radical tissue damage: protective role of antioxidant nutrients. FASEB J 1987;1(6):441-5.
  • Lipincott W. Paraoxonase a cadioprotective en- zyme: continuing issuess. Curr Opin Lipidol 2004;15(3):261-7.
  • Mackness MI, Arrol S, Durrington PN. Paraoxonase prevents accumulation of lipoperoxides in low-density lipoprotein. FEBS Lett 1991;286(1-2):152-4.
  • Haliwell B. Reactive oxygen species in living system: Source biochemistry, and role in human disease. Am J Med 1991(3);91:149-235.
  • Takoudes TG, Haddad J Jr. Lipid peroxides in middle ear fluid after acute otitis media in guinea pigs. Otol Rhinol Laryngol 1999;108(6):564-8.
  • Bodolay E, Seres I, Szodoray P, et al. Evaluation of paraoxonase activity in patients with mixed connec- tive tissue disease. J Rheumatol 2008;35(2):237-43.
  • Selek S, Cosar N, Kocyigit A, et al. PON1 activity and total oxidant status in patients with active pulmonary tuberculosis. Clin Biochem 2008;41(3):140-4.
  • Isik A, Koca SS, Ustundag B, Selek S. Decreased total antioxidant response and increased oxida- tive stress in Behcet’s disease. Tohoku J Exp Med 2007;212(2):133-41.
  • Aslan M, Kosecik M, Horoz M, Selek S, Celik H, Erel O. Assessment of paraoxonase and arylesterase ac- tivities in patients with iron deficiency anemia. Athero- sclerosis 2007; 191(2): 397-402.
  • Emin T, Elkiran N. Serum paraoxonase and ary- lesterase activities in patients with lung cancer in a Turkish population. BMC Cancer 2007;7:48-52.
There are 19 citations in total.

Details

Primary Language Turkish
Journal Section Research Article
Authors

Sema Koç This is me

Fazilet Duygu This is me

Ahmet Eyibilen This is me

Nurten Aksoy This is me

Abdullah Taskin This is me

Hasan Bilinc This is me

Publication Date December 1, 2011
Published in Issue Year 2011

Cite

APA Koç, S., Duygu, F., Eyibilen, A., Aksoy, N., et al. (2011). Serum paraoxanase-1 activity in patients with acute otitis media. Journal of Clinical and Experimental Investigations, 2(4), 412-415. https://doi.org/10.5799/ahinjs.01.2011.04.0083
AMA Koç S, Duygu F, Eyibilen A, Aksoy N, Taskin A, Bilinc H. Serum paraoxanase-1 activity in patients with acute otitis media. J Clin Exp Invest. December 2011;2(4):412-415. doi:10.5799/ahinjs.01.2011.04.0083
Chicago Koç, Sema, Fazilet Duygu, Ahmet Eyibilen, Nurten Aksoy, Abdullah Taskin, and Hasan Bilinc. “Serum Paraoxanase-1 Activity in Patients With Acute Otitis Media”. Journal of Clinical and Experimental Investigations 2, no. 4 (December 2011): 412-15. https://doi.org/10.5799/ahinjs.01.2011.04.0083.
EndNote Koç S, Duygu F, Eyibilen A, Aksoy N, Taskin A, Bilinc H (December 1, 2011) Serum paraoxanase-1 activity in patients with acute otitis media. Journal of Clinical and Experimental Investigations 2 4 412–415.
IEEE S. Koç, F. Duygu, A. Eyibilen, N. Aksoy, A. Taskin, and H. Bilinc, “Serum paraoxanase-1 activity in patients with acute otitis media”, J Clin Exp Invest, vol. 2, no. 4, pp. 412–415, 2011, doi: 10.5799/ahinjs.01.2011.04.0083.
ISNAD Koç, Sema et al. “Serum Paraoxanase-1 Activity in Patients With Acute Otitis Media”. Journal of Clinical and Experimental Investigations 2/4 (December 2011), 412-415. https://doi.org/10.5799/ahinjs.01.2011.04.0083.
JAMA Koç S, Duygu F, Eyibilen A, Aksoy N, Taskin A, Bilinc H. Serum paraoxanase-1 activity in patients with acute otitis media. J Clin Exp Invest. 2011;2:412–415.
MLA Koç, Sema et al. “Serum Paraoxanase-1 Activity in Patients With Acute Otitis Media”. Journal of Clinical and Experimental Investigations, vol. 2, no. 4, 2011, pp. 412-5, doi:10.5799/ahinjs.01.2011.04.0083.
Vancouver Koç S, Duygu F, Eyibilen A, Aksoy N, Taskin A, Bilinc H. Serum paraoxanase-1 activity in patients with acute otitis media. J Clin Exp Invest. 2011;2(4):412-5.