Diagnostic value of urinary pyridinoline for determining bone metastasis in patients with non-metastatic breast cancer

Abstract

Objective: In this study, urinary pyridinoline (uPYR), urinary deoxypyridinoline (uDPD) and serum alkaline phosphatase (sALP) levels were measured in patients without metastatic breast cancer and the role of uPYR and uDPD as biochemical markers of bone metastases were examined during a six years follow-up. Materials and methods: Totally, 34 patients without bone metastasis and 40 healthy individuals as a control group were included in the study. Results: Urinary pyridinoline and uDPD levels were significantly higher in patients without bone metastasis than in normal controls (p

Keywords

• Breast neoplasms, bone metastases, deoxypyridinoline, pyridinoline

Diagnostic value of urinary pyridinoline for determining bone metastasis in patients with non-metastatic breast cancer

Abstract

Amaç: Bu çalışmada metastazı olmayan meme kanserli hastalarda idrar piridinolin, deoksipiridinolin ve serum alkalen fosfataz düzeyleri ölçüldü ve 6 yıllık takipte kemik metastazının biyokimyasal belirteçleri olarak idrar piridinolin ve deoksipiridinolinin rolü değerlendirildi. Gereç ve yöntem: Çalışma kemik metastazı olmayan 34 hasta ve kontrol grubu olarak 40 sağlıklı bireyi içermektedir. Bulgular: Serum ALP hariç idrar piridinolin ve deoksipiridinolin düzeyleri kemik metastazı olmayan hastalarda kontrol grubundan belirgin olarak yüksekti. 6 yıllık takip sonucunda hastaların %20.5\'da metastaz olduğu belirlendi. Metastaz tiplerinin dağılımı: %2.9 lokal, %2.9 karaciğer, %5.9 akciğer ve %8.8 kemik metastazı. Piridinolin için 43 pmol/ µmol kreatinin cut off değerinin sensitiivtesi %82 ve spesifitesi %80 olarak belirlendi. Deoksipiridinolin için 9.53 pmol/ µmol kreatinin cut off değerinin sensitiivtesi %76 ve spesifitesi %72 olarak belirlendi. Sonuç: Bu çalışma idrar çapraz bağlarının ölçümünün meme kanserinde kemiğe metastatik yayılımın erken belirlenmesine katkıda bulunabileceğini gösterdi. Ancak geniş ölçekli gruplarla ileri çalışmalar yapılmalıdır.

Keywords

• Meme kanserleri, kemik metastazları, deoksipiridinolin, piridinolin.

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