The relationship between level of anti-CCP, clinical activity and quality of life in patients with psoriatic arthritis

Abstract

Objectives: Psoriatic arthritis (PsA) is an inflammatory joint disease. The aim of this study was to investigate the titers of Anti-syclic citrullinated protein (anti-CCP antibodies) in PsA and assess their associations with clinical characteristics and quality of life. Materials and methods: Fourty two patients with PsA and 38 healthy control subjects were included. Demographic data and clinical characteristics including age, gender, disease duration, and erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), anti-CCP antibodies and rheumatoid factor were assessed. Visual analog scale (VAS), Nottingham Health Profile (NHP) and short form-36 (SF-36) were used to evaluate QOL in both groups. Results: The demographic data of the subjects were not different between the groups. Patients with PsA had higher anti-CCP levels compared to healthy controls (56.3±73.0 U vs. 0.9±0.5 U, respectively, p=0.01) Thirteen (33.3%) patients with PsA had positive anti-CCP, while no anti-CCP positivity was found in the control group (p

Keywords

• Psoriatic arthritis (PsA), Anti-syclic citrullinated protein (anti-CCP) antibodies, quality of life.

Psoriatik artritli hastalarda anti-CCP düzeyi ile klinik aktivite ve yaşam kalitesi arasındaki ilişki

Öz

Amaç: Psoriatik artrit (PsA); psoriasis ile ilişkili bir kronik inflamatuar eklem hastalığıdır. Bu çalışmada PsA'lı hastalarda Anti-siklik sitrülenmiş protein (anti-CCP) düzeyi ile klinik aktivite ve yaşam kalitesi arasındaki ilişkinin araştırılması amaçlanmıştır. Gereç ve yöntem: Çalışmaya 42 PsA hastası çalışma grubu ve 38 sağlıklı birey kontrol grubu olarak alındı. Demografik ve klinik özellikler; yaş, cinsiyet, hastalık süresi, Eritrosit sedimantasyon hızı (ESH), C-reaktif protein (CRP), anti-CCP antikorları, RF ve vizual ağrı skalası (VAS) ile periferik eklem ağrısı değerlendirildi. Nottingham Sağlık Profili (NHP) ve Short form-36 (SF-36) her iki grupta yaşam kalitesini değerlendirmek için kullanıldı. Bulgular: Gruplar arasındaki demografik özellikler farklı değildi. Anti-CCP antikor düzeyleri PsA hastalarında (56.3±73.0 Ünite) kontrol grubuyla (0.9±0.5 Ünite) karşılaştırıldığında anlamlı yüksek bulundu (p=0.01). Anti-CCP antikoru pozitif birey sayısı PsA'li hasta grubunda kontrol grubuna göre anlamlı olarak yüksekti (%33.3 hastaya karşılık %0) (p

Anahtar Kelimeler

• Psoriatik artrit, Anti-siklik sitrülenmiş protein (anti-CCP) antikoru, yaşam kalitesi

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