Association of multiple myeloma and gastric adenocarcinoma

Abstract

Solid tumors associated with multiple myeloma have been demonstrated. However, it is a controversial subject whether there is a risk factor for the development of a secondary tumor. Here we reported a case with multiple myeloma and gastric adenocarcinoma. A 77 years old male patient was admitted with complaints of bone pain, left leg weakness, weight loss and epigastric pain. Patient's examination revealed monoclonal gammopathy, lytic bone lesions and infiltration of plasma cells in bone marrow. Endoscopic examination revealed a mass in the proximal stomach and pathological examination of ulcerated mass showed gastric adenocarcinoma. Coexistence of these two disease entities needed to be explained by further large-scale researches.

Keywords

• Multiple myeloma, gastric adenocarcinoma, coexistence

Multipl miyeloma ve mide adenokanseri birlikteliği

Öz

Multipl miyeloma ile solid tümör birlikteliği gösterilmiştir. Ancak multipl miyelomanın ikincil bir tümör gelişiminde bir risk faktörü olup olmadığı tartışmalı bir konudur. Biz burada multipl myeloma ve mide adenokarsinomu tanılı bir olgu sunduk. Olgumuz 77 yaşında erkek hasta kemik ağrısı, sol bacakta güçsüzlük, kilo kaybı ve epigastrik ağrı şikayetleri ile başvurdu. Hastada monoklonal gammapati, kemiklerde litik lezyonlar ve kemik iliğinde plazma hücre infiltrasyonu tespit edildi. Endoskopik incelemede midenin kardiya proksimalinde kitle tespit edildi, ülsere kitleden alınan biyopsi örneklerinde adenokarsinom saptandı. Sonuç olarak, bu iki hastalık birlikte görülebilir. Bu iki hastalığın birlikte görülmesinin açıklaması ileri geniş çaplı araştırmaların yapılmasını gerektirmektedir.

Anahtar Kelimeler

• Multipl miyeloma, mide adenokarsinomu, birliktelik

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