Abstract
Solid tumors associated with multiple myeloma have been demonstrated. However, it is a controversial subject whether there is a risk factor for the development of a secondary tumor. Here we reported a case with multiple myeloma and gastric adenocarcinoma. A 77 years old male patient was admitted with complaints of bone pain, left leg weakness, weight loss and epigastric pain. Patient's examination revealed monoclonal gammopathy, lytic bone lesions and infiltration of plasma cells in bone marrow. Endoscopic examination revealed a mass in the proximal stomach and pathological examination of ulcerated mass showed gastric adenocarcinoma. Coexistence of these two disease entities needed to be explained by further large-scale researches.
References
- Pasmantier MW, Azar HA. Extraskeletal spread in multiple plasma cell myeloma. A review of 57 autopsied cases. Cancer 1969; 23:167-174.
- Law IP, Blom J. Second malignancies in patients with mul- tiple myeloma. Oncology 1977; 34: 20-24.
- Stegman R, Alexanian R. Solid tumors in multiple mye- loma. Ann Intern Med 1979; 90: 780-782.
- Kyle RA. Multiple myeloma: review of 869 cases. Mayo Clin Proc 1975; 50: 29-40.
- Kyle RA, Pierre RV, Bayrd ED. Multiple myeloma and acute myelomonocytic leukemia. N Engl J Med 1970; 283: 1121-1125.
- Carson HJ. Unexpected synchronous non-Hodgkin's lym- phoma encountered during the treatment of a previously- diagnosed carcinoma: report of three cases. Leuk Lym- phoma 1996; 23: 625-629.
- Pandey U, Naraynan M, Karnik U, Sinha B. Carcinoma me- tastasis to unexpected synchronous lymphoproliferative disorder: report of three cases and review of literature. J Clin Pathol 2003; 56: 970-971.
- Watanabe S, Harris C. Multiple primary cancer: the U.S.- Japan Cooperative Cancer Research Program. Jpn J Can- cer Res 1990; 81: 201-205.
- International Agency for Research on Cancer. Evaluation of the Carcinogenic Risk of Chemicals to Humans: Overall Evaluations of Carcinogenicity: an up-dating of IARC Monographs. Suppl. 7 1989;1-42.
- Boffetta P, Kaldor JM. Secondary malignancies following cancer chemotherapy. Acta Oncol 1994; 33: 591-598.
- Smith MA, McCaffrey RP, Karp JE. The secondary leu- kemias: challenges and research directions. J Natl Cancer Inst 1996; 88: 407-418.
- Kyle RA, Gertz MA, Witzig TE, et al. Review of 1027 pa- tients with newly diagnosed multiple myeloma. Mayo Clin Proc 2003; 78: 21-33.
- Matsushita S, Matsuzaki H, Kawano F, et al. A case of non-secretory myeloma (accompanied with gastric carci- noma) analyzed with plaque forming cell assay. Rinsho Ketsueki 1984; 25: 393-398.
- Yasuma A, Nakashima I, Muramatsu M, Aoki T, Ota H. A case of multiple myeloma associated with operated stom- ach cancer. Rinsho Ketsueki 1973; 14: 714-720.
- Yamada O, Naito T, Shimazaki M, et al. A case of multi- ple myeloma complicated with early gastric cancer and early sigmoid colon cancer. Nippon Shokakibyo Gakkai Zasshi 1993; 90: 1432-1436.
- Tuncer İ, Uygan İ, Kösem M, Özen S, Uğraş S, Türkdoğan MK. Van ve Çevresinde Görülen Üst Gastrointestinal Sis- tem Kanserlerinin Demografik ve Histopatolojik Özellik- leri Van Tıp Dergisi; 2001; 8: 10-13.
- Ji SH, Park JO, Lee J, et al. Three cases of synchronous solid tumor and multiple myeloma. Cancer Res Treat 2004; 36: 338-340.
Abstract
Multipl miyeloma ile solid tümör birlikteliği gösterilmiştir. Ancak multipl miyelomanın ikincil bir tümör gelişiminde bir risk faktörü olup olmadığı tartışmalı bir konudur. Biz burada multipl myeloma ve mide adenokarsinomu tanılı bir olgu sunduk. Olgumuz 77 yaşında erkek hasta kemik ağrısı, sol bacakta güçsüzlük, kilo kaybı ve epigastrik ağrı şikayetleri ile başvurdu. Hastada monoklonal gammapati, kemiklerde litik lezyonlar ve kemik iliğinde plazma hücre infiltrasyonu tespit edildi. Endoskopik incelemede midenin kardiya proksimalinde kitle tespit edildi, ülsere kitleden alınan biyopsi örneklerinde adenokarsinom saptandı. Sonuç olarak, bu iki hastalık birlikte görülebilir. Bu iki hastalığın birlikte görülmesinin açıklaması ileri geniş çaplı araştırmaların yapılmasını gerektirmektedir.
References
- Pasmantier MW, Azar HA. Extraskeletal spread in multiple plasma cell myeloma. A review of 57 autopsied cases. Cancer 1969; 23:167-174.
- Law IP, Blom J. Second malignancies in patients with mul- tiple myeloma. Oncology 1977; 34: 20-24.
- Stegman R, Alexanian R. Solid tumors in multiple mye- loma. Ann Intern Med 1979; 90: 780-782.
- Kyle RA. Multiple myeloma: review of 869 cases. Mayo Clin Proc 1975; 50: 29-40.
- Kyle RA, Pierre RV, Bayrd ED. Multiple myeloma and acute myelomonocytic leukemia. N Engl J Med 1970; 283: 1121-1125.
- Carson HJ. Unexpected synchronous non-Hodgkin's lym- phoma encountered during the treatment of a previously- diagnosed carcinoma: report of three cases. Leuk Lym- phoma 1996; 23: 625-629.
- Pandey U, Naraynan M, Karnik U, Sinha B. Carcinoma me- tastasis to unexpected synchronous lymphoproliferative disorder: report of three cases and review of literature. J Clin Pathol 2003; 56: 970-971.
- Watanabe S, Harris C. Multiple primary cancer: the U.S.- Japan Cooperative Cancer Research Program. Jpn J Can- cer Res 1990; 81: 201-205.
- International Agency for Research on Cancer. Evaluation of the Carcinogenic Risk of Chemicals to Humans: Overall Evaluations of Carcinogenicity: an up-dating of IARC Monographs. Suppl. 7 1989;1-42.
- Boffetta P, Kaldor JM. Secondary malignancies following cancer chemotherapy. Acta Oncol 1994; 33: 591-598.
- Smith MA, McCaffrey RP, Karp JE. The secondary leu- kemias: challenges and research directions. J Natl Cancer Inst 1996; 88: 407-418.
- Kyle RA, Gertz MA, Witzig TE, et al. Review of 1027 pa- tients with newly diagnosed multiple myeloma. Mayo Clin Proc 2003; 78: 21-33.
- Matsushita S, Matsuzaki H, Kawano F, et al. A case of non-secretory myeloma (accompanied with gastric carci- noma) analyzed with plaque forming cell assay. Rinsho Ketsueki 1984; 25: 393-398.
- Yasuma A, Nakashima I, Muramatsu M, Aoki T, Ota H. A case of multiple myeloma associated with operated stom- ach cancer. Rinsho Ketsueki 1973; 14: 714-720.
- Yamada O, Naito T, Shimazaki M, et al. A case of multi- ple myeloma complicated with early gastric cancer and early sigmoid colon cancer. Nippon Shokakibyo Gakkai Zasshi 1993; 90: 1432-1436.
- Tuncer İ, Uygan İ, Kösem M, Özen S, Uğraş S, Türkdoğan MK. Van ve Çevresinde Görülen Üst Gastrointestinal Sis- tem Kanserlerinin Demografik ve Histopatolojik Özellik- leri Van Tıp Dergisi; 2001; 8: 10-13.
- Ji SH, Park JO, Lee J, et al. Three cases of synchronous solid tumor and multiple myeloma. Cancer Res Treat 2004; 36: 338-340.
Details
| Primary Language | Turkish |
|---|---|
| Journal Section | Case Report |
| Authors | |
| Publication Date | March 1, 2011 |
| Published in Issue | Year 2011 |