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Year 2015, , - , 13.07.2015
https://doi.org/10.5799/ahinjs.01.2015.02.0515

Abstract

Mucosal lesions due to underlying disease or drug toxicity, are important part of oncology practice. Patient with a diagnosis of hepatocellular carcinoma was treated with chemoembolisation. She presented with new onset of mucosal hyperpigmented lesion all through her oral cavity. Biopsy was consistent with mucosal melanosis, which was associated with the chemotherapeutics used in the chemoembolisation procedure. Lesion progressively improved without any treatment. Here we present an mucosal melanosis experience after chemoembolisation. J Clin Exp Invest 2015; 6 (2): 189-191

References

  • Merchant HW. Oral pigmentation associated with bronchogenic carcinoma. Oral Surg Oral Med Oral Pathol 1973;36:657.
  • Mostofi RS, Hayden NP, Soltani K. Oral malignant acanthosis nigricans. Oral Surg Oral Med Oral Pathol 1983;56:372-374.
  • Guillot B, Bessis D, Dereure O. Mucocutaneous side effects of antineoplastic chemotherapy. Expert Opin Drug Saf 2004;3:579-587.
  • Kew MC, Mzamane D, Smith AG, Shuster S. Melanocyte-stimulating-hormone levels in doxorubicin-induced hyperpigmentation. Lancet 1977;1:811.
  • Law IP. Doxorubicin and unusual skin manifestations. Arch Dermatol 1977;113:379-380.
  • Rao SP, Potnis AV, Sobrinho TC, Brown AK. Pigmentation of the tongue after treatment with adriamycin. Cancer Treat Rep 1976;60:1402-1404.
  • Kurli M, Finger PT. Topical mitomycin chemotherapy for conjunctival malignant melanoma and primary acquired melanosis with atypia: 12 years’ experience. Graefes Arch Clin Exp Ophthalmol 2005;243:1108-1114.
  • Kim KJ, Chang SE, Choi JH, et al. Periungal hyperpigmentation induced by cisplatin. Clin Exp Dermatol 2002;27:118-119.

Kemoembolizasyon ilişkili mukozal melanosis

Year 2015, , - , 13.07.2015
https://doi.org/10.5799/ahinjs.01.2015.02.0515

Abstract

Cilt ve mukozal lezyonlar onkoloji pratiğinin önemli birer parçalarıdır. Gerek altta yatan hastalık gerekse kullanılan ilaçlarla ilişkili lezyonlar sıklıkla görülmektedir. Hepatoselüler kanser tanısı ile izlenmekte olan hasta, lokal hastalığa yönelik uygulanan kemoembolizasyon sonrasında oral mukozada hiperpigmente lezyonlar ile başvurdu. Mukozal biyopsi melanozis olarak değerlendirildi ve yeni gelişimli lezyonlar uygulanmış olan kemoterapötikler ile ilişkilendirildi. Lezyonlar sayı ve boyut olarak gerilese de izlemde sebat etti. Burada nadir bir vaka olan kemoembolizasyon ilişkili mukozal melanozis tecrübesi sunulmuştur.

Anahtar kelimeler: Mukozal melanozis, hiperpigmentasyon, adriamisin, kemoembolizasyon

References

  • Merchant HW. Oral pigmentation associated with bronchogenic carcinoma. Oral Surg Oral Med Oral Pathol 1973;36:657.
  • Mostofi RS, Hayden NP, Soltani K. Oral malignant acanthosis nigricans. Oral Surg Oral Med Oral Pathol 1983;56:372-374.
  • Guillot B, Bessis D, Dereure O. Mucocutaneous side effects of antineoplastic chemotherapy. Expert Opin Drug Saf 2004;3:579-587.
  • Kew MC, Mzamane D, Smith AG, Shuster S. Melanocyte-stimulating-hormone levels in doxorubicin-induced hyperpigmentation. Lancet 1977;1:811.
  • Law IP. Doxorubicin and unusual skin manifestations. Arch Dermatol 1977;113:379-380.
  • Rao SP, Potnis AV, Sobrinho TC, Brown AK. Pigmentation of the tongue after treatment with adriamycin. Cancer Treat Rep 1976;60:1402-1404.
  • Kurli M, Finger PT. Topical mitomycin chemotherapy for conjunctival malignant melanoma and primary acquired melanosis with atypia: 12 years’ experience. Graefes Arch Clin Exp Ophthalmol 2005;243:1108-1114.
  • Kim KJ, Chang SE, Choi JH, et al. Periungal hyperpigmentation induced by cisplatin. Clin Exp Dermatol 2002;27:118-119.
There are 8 citations in total.

Details

Primary Language Turkish
Journal Section Case Report
Authors

Ali Alkan

Dılşa Mızrak This is me

Seçkin Özgül This is me

Güngör Utkan This is me

Publication Date July 13, 2015
Published in Issue Year 2015

Cite

APA Alkan, A., Mızrak, D., Özgül, S., Utkan, G. (2015). Kemoembolizasyon ilişkili mukozal melanosis. Journal of Clinical and Experimental Investigations, 6(2). https://doi.org/10.5799/ahinjs.01.2015.02.0515
AMA Alkan A, Mızrak D, Özgül S, Utkan G. Kemoembolizasyon ilişkili mukozal melanosis. J Clin Exp Invest. July 2015;6(2). doi:10.5799/ahinjs.01.2015.02.0515
Chicago Alkan, Ali, Dılşa Mızrak, Seçkin Özgül, and Güngör Utkan. “Kemoembolizasyon ilişkili Mukozal Melanosis”. Journal of Clinical and Experimental Investigations 6, no. 2 (July 2015). https://doi.org/10.5799/ahinjs.01.2015.02.0515.
EndNote Alkan A, Mızrak D, Özgül S, Utkan G (July 1, 2015) Kemoembolizasyon ilişkili mukozal melanosis. Journal of Clinical and Experimental Investigations 6 2
IEEE A. Alkan, D. Mızrak, S. Özgül, and G. Utkan, “Kemoembolizasyon ilişkili mukozal melanosis”, J Clin Exp Invest, vol. 6, no. 2, 2015, doi: 10.5799/ahinjs.01.2015.02.0515.
ISNAD Alkan, Ali et al. “Kemoembolizasyon ilişkili Mukozal Melanosis”. Journal of Clinical and Experimental Investigations 6/2 (July 2015). https://doi.org/10.5799/ahinjs.01.2015.02.0515.
JAMA Alkan A, Mızrak D, Özgül S, Utkan G. Kemoembolizasyon ilişkili mukozal melanosis. J Clin Exp Invest. 2015;6. doi:10.5799/ahinjs.01.2015.02.0515.
MLA Alkan, Ali et al. “Kemoembolizasyon ilişkili Mukozal Melanosis”. Journal of Clinical and Experimental Investigations, vol. 6, no. 2, 2015, doi:10.5799/ahinjs.01.2015.02.0515.
Vancouver Alkan A, Mızrak D, Özgül S, Utkan G. Kemoembolizasyon ilişkili mukozal melanosis. J Clin Exp Invest. 2015;6(2).