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Abstract

Mucosal lesions due to underlying disease or drug toxicity, are important part of oncology practice. Patient with a diagnosis of hepatocellular carcinoma was treated with chemoembolisation. She presented with new onset of mucosal hyperpigmented lesion all through her oral cavity. Biopsy was consistent with mucosal melanosis, which was associated with the chemotherapeutics used in the chemoembolisation procedure. Lesion progressively improved without any treatment. Here we present an mucosal melanosis experience after chemoembolisation. J Clin Exp Invest 2015; 6 (2): 189-191

Keywords

• Mucosal melanosis, hyperpigmentation, adriamycin, chemoembolization

Kemoembolizasyon ilişkili mukozal melanosis

Abstract

Cilt ve mukozal lezyonlar onkoloji pratiğinin önemli birer parçalarıdır. Gerek altta yatan hastalık gerekse kullanılan ilaçlarla ilişkili lezyonlar sıklıkla görülmektedir. Hepatoselüler kanser tanısı ile izlenmekte olan hasta, lokal hastalığa yönelik uygulanan kemoembolizasyon sonrasında oral mukozada hiperpigmente lezyonlar ile başvurdu. Mukozal biyopsi melanozis olarak değerlendirildi ve yeni gelişimli lezyonlar uygulanmış olan kemoterapötikler ile ilişkilendirildi. Lezyonlar sayı ve boyut olarak gerilese de izlemde sebat etti. Burada nadir bir vaka olan kemoembolizasyon ilişkili mukozal melanozis tecrübesi sunulmuştur.

Anahtar kelimeler: Mukozal melanozis, hiperpigmentasyon, adriamisin, kemoembolizasyon

Keywords

• Mukozal melanozis, hiperpigmentasyon, adriamisin, kemoembolizasyon

References

1. Merchant HW. Oral pigmentation associated with bronchogenic carcinoma. Oral Surg Oral Med Oral Pathol 1973;36:657.
2. Mostofi RS, Hayden NP, Soltani K. Oral malignant acanthosis nigricans. Oral Surg Oral Med Oral Pathol 1983;56:372-374.
3. Guillot B, Bessis D, Dereure O. Mucocutaneous side effects of antineoplastic chemotherapy. Expert Opin Drug Saf 2004;3:579-587.
4. Kew MC, Mzamane D, Smith AG, Shuster S. Melanocyte-stimulating-hormone levels in doxorubicin-induced hyperpigmentation. Lancet 1977;1:811.
5. Law IP. Doxorubicin and unusual skin manifestations. Arch Dermatol 1977;113:379-380.
6. Rao SP, Potnis AV, Sobrinho TC, Brown AK. Pigmentation of the tongue after treatment with adriamycin. Cancer Treat Rep 1976;60:1402-1404.
7. Kurli M, Finger PT. Topical mitomycin chemotherapy for conjunctival malignant melanoma and primary acquired melanosis with atypia: 12 years’ experience. Graefes Arch Clin Exp Ophthalmol 2005;243:1108-1114.
8. Kim KJ, Chang SE, Choi JH, et al. Periungal hyperpigmentation induced by cisplatin. Clin Exp Dermatol 2002;27:118-119.