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Uterine pathologies to be considered before uterus-preserving surgery in cases of uterine prolapse

Year 2015, , 364 - 368, 03.01.2016
https://doi.org/10.5799/ahinjs.01.2015.04.0550

Abstract

Objective: Investigation of unpredictable risks due to abnormal uterine pathology after the choice of uterus-preserving reconstructive surgical procedure for women who have uterine prolapse and no other complaints was aimed.

Methods: The data of 121 women (105 postmenopausal and 16 premenopausal) who underwent vaginal hysterectomy due to pelvic organ prolapse was examined and the post-hysterectomy histopathology results were evaluated.

Results: Senile cystic atrophy was the most common endometrial pathology result among postmenopausal women (63.5%). However, proliferative and secretory endometrium was the most common endometrial pathology finding among premenopausal women (81.3%). There were statistically significant differences between postmenopausal and perimenopausal women in terms of these pathology results (p<0.001). While, there was no difference between groups in terms of endometrial polyps, hyperplasia and adenomyosis (p>0.05), myoma uteri was significantly more common in patients with perimenopause (p=0.01).

Conclusion: The uterus must be evaluated in terms of endometrial pathologies in asymptomatic women with pelvic organ prolapse before uterus-preserving reconstructive surgical procedure, especially in postmenopausal period. J Clin Exp Invest 2015; 6 (4): 443-446

Key words: Pelvic organ prolapse, vaginal hysterectomy, endometrium

References

  • Baden WF, Walker TA. Genesis of the vaginal profile: a correlated classification of vaginal relaxation. Clin Obstet Gynecol 1972;15:1048-1054.
  • Handa VL, Garrett E, Hendrix S, et al. Progression and remission of pelvic organ prolapse: a longitudinal study of menopausal women. Am J Obstet Gynecol. 2004;190:27-32.
  • Okonkwo JE, Obiechina NJ, Obionu CN. Incidence of pelvic organ prolapse in Nigerian women. J Natl Med Assoc 2003;95:132-136.
  • Olsen AL, Smith VJ, Bergstrom JO, et al. Epidemiology of surgically managed pelvic organ prolapse and urinary incontinence. Obstet Gynecol 1997;89:501–506.
  • Woodman PJ, Swift SE, O’Boyle AL, et al. Prevalence of severe pelvic organ prolapse in relation to job description and socioeconomic status: a multicenter cross-sectional study. Int Urogynecol J Pelvic Floor Dysfunct 2006;17:340-345.
  • MacLennan AH, Taylor AW, DH Wilson, Wilson D. The prevalence of pelvic floor disorders and their relationship to gender, age, parity and mode of delivery.BJOG 2000;107:1460–1470.
  • Jackson SR, Avery NC, Tarlton JF, et al. Changes in metabolism of collagen in genitourinary prolapse. Lancet 1996;347:1658–1661.
  • Chiaffarino F, Chatenoud L, Dindelli M, et al. Reproductive factors, family history, occupation and risk of urogenital prolapse. Eur J Obstet Gynecol Reprod Biol 1999;82:63–67.
  • Jelovsek JE, Maher C, Barber MD. Pelvic organ prolapse. Lancet 2007;369:1027–1038.
  • Olsen AL, Smith VJ, Bergstrom JO, et al. Epidemiology of surgically managed pelvic organ prolapse and urinary incontinence. Obstet Gynecol 1997;89:501–506.
  • Fialkow MF, Newton KM, Lentz GM, Weiss NS. Lifetime risk of surgical management for pelvic organ prolapse or urinary incontinence. Int Urogynecol J Pelvic Floor Dysfunct 2008;19:437–440.
  • Costantini E, Lazzeri M. What part does mesh play in urogenital prolapse management today? Curr Opin Urol 2015;25:300-304.
  • Maher C, Baessler K, Glazener CM, et al. Surgical management of pelvic organ prolapse in women: a short version Cochrane review. Neurourol Urodyn 2008;27:3-12.
  • Bump RC, Mattiasson A, Bø K, et al. The standardization of terminology of female pelvic organ prolapse and pelvic floor dysfunction. American Journal of Obstetrics and Gynecology 1996;175:10-17.
  • Lousquy R, Costa P, Delmas V, Haab F. [Update on the epidemiology of genital prolapse]. Prog Urol 2009;19:907-915.
  • Chow D, Rodríguez LV. Epidemiology and prevalence of pelvic organ prolapse. Curr Opin Urol 2013;23:293-298.
  • Chung da J, Bai SW. Roles of sex steroid receptors and cell cycle regulation in pathogenesis of pelvic organ prolapse. Curr Opin Obstet Gynecol 2006;18:551-554.
  • Chen HY, Wan L, Chung YW, et al. Estrogen receptor beta gene haplotype is associated with pelvic organ prolapse. Eur J Obstet Gynecol Reprod Biol 2008;138:105-109.
  • Chen HY, Chung YW, Lin WY, et al. Progesterone receptor
  • polymorphism is associated with pelvic organ prolapse risk. Acta Obstet Gynecol Scand 2009;88:835-838.
  • Mingels MJ, Geels YP, Pijnenborg JM, et al. Histopathologic
  • assessment of the entire endometrium in asymptomatic women. Hum Pathol 2013;44:2293-2301.
  • Dreisler E, Poulsen LG, Antonsen SL, et al. EMAS clinical guide: Asessment of the endometrium in peri and postmenopausal women. Maturitas 2013;75:181-190.
  • Maruo T, Ohara N, Wang J, Matsuo H. Sex steroidal regulation of uterine leiomyoma growth and apoptosis. Hum Reprod 2004;10:207-220.
  • Ferenczy A. Pathophysiology of adenomyosis. Hum Reprod Update 1998;4:312-322.
  • Frick AC, Walters MD, Larkin KS, Barber MD. Risk of unanticipated abnormal gynecologic pathology at thetime of ysterectomy for uterovaginal prolapse. Am J Obstet Gynecol. 2010;202:507.
  • Jones R NHJ, Healy JC, King LJ, et al. Pelvic connective tissue resilience decreases with vaginal delivery,menopause and uterine prolapse. Br J Surg 2003;90:466-472.
  • Sivridis E, Giatromanolaki A. Proliferative activity in postmenopausal endometrium: the lurking potential for giving rise to an endometrial adenocarcinoma. J Clin Pathol 2004;57:840-844.
  • Modugno F, Ness RB, Chen C, Weiss NS. Inflammation and endometrial cancer: a hypothesis. Cancer Epidemiol Biomarkers Prev 2005;14:2840-2847.
  • Wallace AE, Gibson DA, Saunders PT, Jabbour HN.Inflammatory events in endometrial adenocarcinoma.J Endocrinol 2010;206:141-157.
  • Bohoussou E, Adjoussou SA, Letouzey V, et al.[Should we perform intra-operative endometrial biopsy during pelvic reconstructive surgery with uterine preservation?]. J Gynecol Obstet Biol Reprod (Paris) 2014;43:40-45.
  • Sherman ME. Theories of endometrial carcinogenesis:a multidisciplinary approach. Mod Pathol 2000;13:295-308.
Year 2015, , 364 - 368, 03.01.2016
https://doi.org/10.5799/ahinjs.01.2015.04.0550

Abstract

References

  • Baden WF, Walker TA. Genesis of the vaginal profile: a correlated classification of vaginal relaxation. Clin Obstet Gynecol 1972;15:1048-1054.
  • Handa VL, Garrett E, Hendrix S, et al. Progression and remission of pelvic organ prolapse: a longitudinal study of menopausal women. Am J Obstet Gynecol. 2004;190:27-32.
  • Okonkwo JE, Obiechina NJ, Obionu CN. Incidence of pelvic organ prolapse in Nigerian women. J Natl Med Assoc 2003;95:132-136.
  • Olsen AL, Smith VJ, Bergstrom JO, et al. Epidemiology of surgically managed pelvic organ prolapse and urinary incontinence. Obstet Gynecol 1997;89:501–506.
  • Woodman PJ, Swift SE, O’Boyle AL, et al. Prevalence of severe pelvic organ prolapse in relation to job description and socioeconomic status: a multicenter cross-sectional study. Int Urogynecol J Pelvic Floor Dysfunct 2006;17:340-345.
  • MacLennan AH, Taylor AW, DH Wilson, Wilson D. The prevalence of pelvic floor disorders and their relationship to gender, age, parity and mode of delivery.BJOG 2000;107:1460–1470.
  • Jackson SR, Avery NC, Tarlton JF, et al. Changes in metabolism of collagen in genitourinary prolapse. Lancet 1996;347:1658–1661.
  • Chiaffarino F, Chatenoud L, Dindelli M, et al. Reproductive factors, family history, occupation and risk of urogenital prolapse. Eur J Obstet Gynecol Reprod Biol 1999;82:63–67.
  • Jelovsek JE, Maher C, Barber MD. Pelvic organ prolapse. Lancet 2007;369:1027–1038.
  • Olsen AL, Smith VJ, Bergstrom JO, et al. Epidemiology of surgically managed pelvic organ prolapse and urinary incontinence. Obstet Gynecol 1997;89:501–506.
  • Fialkow MF, Newton KM, Lentz GM, Weiss NS. Lifetime risk of surgical management for pelvic organ prolapse or urinary incontinence. Int Urogynecol J Pelvic Floor Dysfunct 2008;19:437–440.
  • Costantini E, Lazzeri M. What part does mesh play in urogenital prolapse management today? Curr Opin Urol 2015;25:300-304.
  • Maher C, Baessler K, Glazener CM, et al. Surgical management of pelvic organ prolapse in women: a short version Cochrane review. Neurourol Urodyn 2008;27:3-12.
  • Bump RC, Mattiasson A, Bø K, et al. The standardization of terminology of female pelvic organ prolapse and pelvic floor dysfunction. American Journal of Obstetrics and Gynecology 1996;175:10-17.
  • Lousquy R, Costa P, Delmas V, Haab F. [Update on the epidemiology of genital prolapse]. Prog Urol 2009;19:907-915.
  • Chow D, Rodríguez LV. Epidemiology and prevalence of pelvic organ prolapse. Curr Opin Urol 2013;23:293-298.
  • Chung da J, Bai SW. Roles of sex steroid receptors and cell cycle regulation in pathogenesis of pelvic organ prolapse. Curr Opin Obstet Gynecol 2006;18:551-554.
  • Chen HY, Wan L, Chung YW, et al. Estrogen receptor beta gene haplotype is associated with pelvic organ prolapse. Eur J Obstet Gynecol Reprod Biol 2008;138:105-109.
  • Chen HY, Chung YW, Lin WY, et al. Progesterone receptor
  • polymorphism is associated with pelvic organ prolapse risk. Acta Obstet Gynecol Scand 2009;88:835-838.
  • Mingels MJ, Geels YP, Pijnenborg JM, et al. Histopathologic
  • assessment of the entire endometrium in asymptomatic women. Hum Pathol 2013;44:2293-2301.
  • Dreisler E, Poulsen LG, Antonsen SL, et al. EMAS clinical guide: Asessment of the endometrium in peri and postmenopausal women. Maturitas 2013;75:181-190.
  • Maruo T, Ohara N, Wang J, Matsuo H. Sex steroidal regulation of uterine leiomyoma growth and apoptosis. Hum Reprod 2004;10:207-220.
  • Ferenczy A. Pathophysiology of adenomyosis. Hum Reprod Update 1998;4:312-322.
  • Frick AC, Walters MD, Larkin KS, Barber MD. Risk of unanticipated abnormal gynecologic pathology at thetime of ysterectomy for uterovaginal prolapse. Am J Obstet Gynecol. 2010;202:507.
  • Jones R NHJ, Healy JC, King LJ, et al. Pelvic connective tissue resilience decreases with vaginal delivery,menopause and uterine prolapse. Br J Surg 2003;90:466-472.
  • Sivridis E, Giatromanolaki A. Proliferative activity in postmenopausal endometrium: the lurking potential for giving rise to an endometrial adenocarcinoma. J Clin Pathol 2004;57:840-844.
  • Modugno F, Ness RB, Chen C, Weiss NS. Inflammation and endometrial cancer: a hypothesis. Cancer Epidemiol Biomarkers Prev 2005;14:2840-2847.
  • Wallace AE, Gibson DA, Saunders PT, Jabbour HN.Inflammatory events in endometrial adenocarcinoma.J Endocrinol 2010;206:141-157.
  • Bohoussou E, Adjoussou SA, Letouzey V, et al.[Should we perform intra-operative endometrial biopsy during pelvic reconstructive surgery with uterine preservation?]. J Gynecol Obstet Biol Reprod (Paris) 2014;43:40-45.
  • Sherman ME. Theories of endometrial carcinogenesis:a multidisciplinary approach. Mod Pathol 2000;13:295-308.
There are 32 citations in total.

Details

Primary Language Turkish
Journal Section Research Article
Authors

Fatma Eskicioğu

Beyhan Özyurt This is me

Publication Date January 3, 2016
Published in Issue Year 2015

Cite

APA Eskicioğu, F., & Özyurt, B. (2016). Uterine pathologies to be considered before uterus-preserving surgery in cases of uterine prolapse. Journal of Clinical and Experimental Investigations, 6(4), 364-368. https://doi.org/10.5799/ahinjs.01.2015.04.0550
AMA Eskicioğu F, Özyurt B. Uterine pathologies to be considered before uterus-preserving surgery in cases of uterine prolapse. J Clin Exp Invest. January 2016;6(4):364-368. doi:10.5799/ahinjs.01.2015.04.0550
Chicago Eskicioğu, Fatma, and Beyhan Özyurt. “Uterine Pathologies to Be Considered before Uterus-Preserving Surgery in Cases of Uterine Prolapse”. Journal of Clinical and Experimental Investigations 6, no. 4 (January 2016): 364-68. https://doi.org/10.5799/ahinjs.01.2015.04.0550.
EndNote Eskicioğu F, Özyurt B (January 1, 2016) Uterine pathologies to be considered before uterus-preserving surgery in cases of uterine prolapse. Journal of Clinical and Experimental Investigations 6 4 364–368.
IEEE F. Eskicioğu and B. Özyurt, “Uterine pathologies to be considered before uterus-preserving surgery in cases of uterine prolapse”, J Clin Exp Invest, vol. 6, no. 4, pp. 364–368, 2016, doi: 10.5799/ahinjs.01.2015.04.0550.
ISNAD Eskicioğu, Fatma - Özyurt, Beyhan. “Uterine Pathologies to Be Considered before Uterus-Preserving Surgery in Cases of Uterine Prolapse”. Journal of Clinical and Experimental Investigations 6/4 (January 2016), 364-368. https://doi.org/10.5799/ahinjs.01.2015.04.0550.
JAMA Eskicioğu F, Özyurt B. Uterine pathologies to be considered before uterus-preserving surgery in cases of uterine prolapse. J Clin Exp Invest. 2016;6:364–368.
MLA Eskicioğu, Fatma and Beyhan Özyurt. “Uterine Pathologies to Be Considered before Uterus-Preserving Surgery in Cases of Uterine Prolapse”. Journal of Clinical and Experimental Investigations, vol. 6, no. 4, 2016, pp. 364-8, doi:10.5799/ahinjs.01.2015.04.0550.
Vancouver Eskicioğu F, Özyurt B. Uterine pathologies to be considered before uterus-preserving surgery in cases of uterine prolapse. J Clin Exp Invest. 2016;6(4):364-8.