The expression of Fetuin-A in brain tissues of WAG/Rij Rats, genetic rat model of absence epilepsy

Ramazan Yüksel; Gönül Gürol; Zeynep Akkılık; Sibel Sarı; Sevil Arabacı; Didem Güneri; Kadir Demircan; Fatih Ekici

doi:10.5799/ahinjs.01.2015.04.0554

The expression of Fetuin-A in brain tissues of WAG/Rij Rats, genetic rat model of absence epilepsy

Abstract

Objective: In the present study, we aimed to determine the Fetuin-A levels in different regions of the brain in absence epileptic Wistar Albino Glaxo/Rijswijk (WAG/Rij) rats in order to contribute the identification of new potential biomarkers of the diagnosis, prognosis and follow up the epilepsy treatment.

Methods: 1, 3 and 6 months old male WAG/Rij rats (n=21) with absence epilepsy were used in this study. All of the rats were decapitated under anesthesia and their cortex and thalamus tissues were isolated. Fetuin-A levels of the groups were determined by Western Blot method by using standard techniques and differences between densities of the groups were compared.

Results: According to data obtained, there was no Fetuin-A expression in brain cortex and thalamus tissues of WAG/Rij rats with absence epilepsy.

Conclusion: In this study, it was shown that Fetuin-A is not expressed in brain cortex and thalamus tissues of WAG/Rij rats with absence epilepsy throughout the age-related development. By evaluating the findings obtained, extensive researches that contain molecular and histological methods must be planned, Fetuin-A findings that are obtained experimentally must be confirmed. J Clin Exp Invest 2015; 6 (4): 387-390

Key words: Absence epilepsy, Fetuin-A, WAG/Rij rat

Keywords

Absans epilepsi, Fetuin-A, WAG/Rij sıçan

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Details

Primary Language

Turkish

Subjects

-

Journal Section

-

Authors

Ramazan Yüksel

Gönül Gürol This is me

Zeynep Akkılık This is me

Sibel Sarı This is me

Sevil Arabacı This is me

Didem Güneri This is me

Kadir Demircan This is me

Fatih Ekici This is me

Publication Date

January 3, 2016

Submission Date

January 3, 2016

Acceptance Date

-

Published in Issue

Year 2015 Volume: 6 Number: 4

DOI

https://doi.org/10.5799/ahinjs.01.2015.04.0554

IZ

https://izlik.org/JA94JL43EY

Cite

RIS / Bibtex

APA

Yüksel, R., Gürol, G., Akkılık, Z., Sarı, S., Arabacı, S., Güneri, D., Demircan, K., & Ekici, F. (2016). The expression of Fetuin-A in brain tissues of WAG/Rij Rats, genetic rat model of absence epilepsy. Journal of Clinical and Experimental Investigations, 6(4), 387-390. https://doi.org/10.5799/ahinjs.01.2015.04.0554

AMA

1.Yüksel R, Gürol G, Akkılık Z, et al. The expression of Fetuin-A in brain tissues of WAG/Rij Rats, genetic rat model of absence epilepsy. J Clin Exp Invest. 2016;6(4):387-390. doi:10.5799/ahinjs.01.2015.04.0554

Chicago

Yüksel, Ramazan, Gönül Gürol, Zeynep Akkılık, et al. 2016. “The Expression of Fetuin-A in Brain Tissues of WAG Rij Rats, Genetic Rat Model of Absence Epilepsy”. Journal of Clinical and Experimental Investigations 6 (4): 387-90. https://doi.org/10.5799/ahinjs.01.2015.04.0554.

EndNote

Yüksel R, Gürol G, Akkılık Z, Sarı S, Arabacı S, Güneri D, Demircan K, Ekici F (January 1, 2016) The expression of Fetuin-A in brain tissues of WAG/Rij Rats, genetic rat model of absence epilepsy. Journal of Clinical and Experimental Investigations 6 4 387–390.

IEEE

[1]R. Yüksel et al., “The expression of Fetuin-A in brain tissues of WAG/Rij Rats, genetic rat model of absence epilepsy”, J Clin Exp Invest, vol. 6, no. 4, pp. 387–390, Jan. 2016, doi: 10.5799/ahinjs.01.2015.04.0554.

ISNAD

Yüksel, Ramazan - Gürol, Gönül - Akkılık, Zeynep - Sarı, Sibel - Arabacı, Sevil - Güneri, Didem - Demircan, Kadir - Ekici, Fatih. “The Expression of Fetuin-A in Brain Tissues of WAG Rij Rats, Genetic Rat Model of Absence Epilepsy”. Journal of Clinical and Experimental Investigations 6/4 (January 1, 2016): 387-390. https://doi.org/10.5799/ahinjs.01.2015.04.0554.

JAMA

1.Yüksel R, Gürol G, Akkılık Z, Sarı S, Arabacı S, Güneri D, Demircan K, Ekici F. The expression of Fetuin-A in brain tissues of WAG/Rij Rats, genetic rat model of absence epilepsy. J Clin Exp Invest. 2016;6:387–390.

MLA

Yüksel, Ramazan, et al. “The Expression of Fetuin-A in Brain Tissues of WAG Rij Rats, Genetic Rat Model of Absence Epilepsy”. Journal of Clinical and Experimental Investigations, vol. 6, no. 4, Jan. 2016, pp. 387-90, doi:10.5799/ahinjs.01.2015.04.0554.

Vancouver

1.Ramazan Yüksel, Gönül Gürol, Zeynep Akkılık, Sibel Sarı, Sevil Arabacı, Didem Güneri, Kadir Demircan, Fatih Ekici. The expression of Fetuin-A in brain tissues of WAG/Rij Rats, genetic rat model of absence epilepsy. J Clin Exp Invest. 2016 Jan. 1;6(4):387-90. doi:10.5799/ahinjs.01.2015.04.0554