Current approach to metastasis of extra-genital system malignancies to the female genital tract

Kemal Güngördük; Varol Gülseren; Muzaffer Sancı

doi:10.5799/ahinjs.01.2015.04.0559

Current approach to metastasis of extra-genital system malignancies to the female genital tract

Öz

Metastases to the female genital tract from extra-genital malignancies are very uncommon and have a poor prognosis. The most common extra-genital primary sites are breast and gastrointestinal system. The ovaries are frequent targets of metastasis for malignant tumors. Distinction between primary and metastatic tumors is important because misinterpretation of a metastatic tumor as primary tumor may lead to inappropriate management and suboptimal treatment outcome. The routes of tumor spread to the genital system are variable such as lymphatic and hematogenous metastasis or direct extension. Multidisciplinary approach is required to management and follow-up for these patients. J Clin Exp Invest 2015; 6 (4): 406-413

Key words: Female genital tract, extragenital malignancies, multidisciplinary approach

Anahtar Kelimeler

Kadın genital sistemi, ekstra genital tümörler, multidisipliner yaklaşım

References

Neto AG, Deavers MT, Silva EG, et al. Metastatic tumors of the vulva: a clinicopathologic study of 66 cases. Am J Surg Pathol 2003;27:799–804.
Canavan TP, Cohen D. Vulvar cancer. Am Fam Physician. 2002;66:1269–1274.
Stueben BL, Lara JF. Primary adnexal adenocarcinoma of the vulva: a diagnosis of exclusion based on location, immunohistochemistry, and pattern of spread.Gynecol Oncol Case Rep 2012;17;4:7–8.
David RW, Brian SK, Katalin F, et al. Cutaneous vulvar metastases in a patient with anal squamous cell carcinoma. Cutis 2013;9:125-126.
Kexing R, Xuelei M, Feng W, et al. Metachronous metastasis from the right colon adenocarcinoma to the vulva: an unusual report and literature review. Int J Clin Exp Pathol 2015;8:1000-1006.
Hu SC, Chen GS, Wu CS, et al. Rates of cutaneous metastases from different internal malignancies: experience from a Taiwanese medical center. J Am Acad Dermatol.2009;60:379-387.
Schwartz RA. Cutaneous metastatic disease. J Am Acad Dermatol. 1995;33:161-182.
Ji HS, Jung EK, Sang H L, et al. Vulvar skin metastasis of lung squamous cell carcinoma. Ann Dermatol 2011.23.S2.S179.

Brownstein MH, Helwig EB. Patterns of cutaneous metastasis. Arch Dermatol 1972;105:862-868.
N. Mullai, Zewdu Lissanu .Vulvar metastasis from breast cancer. Community Oncology 2006;3:106–109.
Shinagare AB, Ramaiya NH, Jagannathan JP, et al. Metastatic pattern of bladder cancer: correlation with the characteristics of the primary tumor. Am J Roentgenol 2011;196:117-112.
Guven EO, Kilciler M, Bedir S, et al. Transitional cell carcinoma of the clitoris: direct implantation or metastasis. International Urology and Nephrology 2007;39,3:829-831.
Jemal A, Siegel R, Ward E, et al. Cancer statistics, 2009. CA Cancer J Clin 2009; 59:225–249.
Fu YS, Reagan JW. Pathology of the uterine cervix, vagina, and vulva. Teratology 1989;397.
Tanaka T, Kanda T, Sakaguchi S, et al. Vaginal stump metastasis from sigmoid colon cancer. novel insights from clinical practice. Acta Cytologica 2012;56:92–96.
Pais Costa SR, Pinto Antunes RC, Abraão AT, et al. Single vaginal metastasis from cancer of the right colon:case report. Einstein 2009;7,2:219-221.
Yagci G, Cetiner S, Dede M, et al. True vaginal metastasis of rectal cancer. Indian J Surg 2005;67,5:270-272.
Soares LC, de Camaret AC. Metastasis of ductal breast carcinoma to the vagina: a case report. Oncology 2013;1:76-79.
Bellati F, Palaia I, Gasparri ML, et al. First case of isolated vaginal metastasis from breast cancer treated by surgery. BMC Cancer 2012;12:479.
Benhayoune K, El Fatemi H, El Ghaouti M, et al. Vaginal metastasis of pancreatic cancer. Pan African Medical Journal 2015;20:124.
Berhili S, El Khannoussi B, Kadiri S, et al. Uterine cervix metastasis from a sigmoid adenocarcinoma: a rare presentation of an uncommon tumor. Gynecol Oncol Res Pract 2014;1:6.
William P, Abraham M. Adenocarcinoma of the cervix. Am J Obstet GynecoI 1962;84:367–374.
Korhonen M, Stenback F. Adenocarcinoma metastatic to the uterine cervix. Gynecol Obstet Invest 1984;17:57–65.
Ogino A , Nomizu T, Gonnda K , et al. A case of breast cancer metastasizing to cervix after resection of pancreatic metastasis. Breast Cancer Vol 2003;10,3:284-288.
Perišic D, Jancˇic S, Kalinovic D , et al. Metastasis of lobular breast carcinoma to the cervix. J. Obstet Gynaecol 2007;33:578-580.
Nakagami K, Takahashi T, Sugitani K, et al. Uterine cervix metastasis from rectal carcinoma : a case report and a review of the literature. Jpn J Clin Oncol 1999;29:640–642.
Matsuura M, Tamate M, Suzuki S, et al. Metastatic carcinoma of the uterine cervix from rectal carcinoma: a case report and review of the literature. Open J Obstetr Gynecol 2014;4,617-620.
Lee P, Paek J, Ji Nam E, et al. A case of stomach cancer metastatic to the uterine cervix. J Womens Med 2011;4,1:23-26.
AlArifi M, Riaz K, Ali Tunio M, et al. Uterine cervix metastasis as an initial manifestation of metastatic renal cell carcinoma: a case report and review of literature. J Nucl Med Radiat Ther 2012; S:6.
Arslan D, Tural D, Tatlı AM, et al. Isolated Uterine Metastasis of Invasive Ductal Carcinoma. Case Reports in Oncological Medicine. 2013;3.
Di Tommaso L, Rahal D, Bresciani G, et al. Cutaneous Melanoma Metastatic to Uterine Adenomyoma. Int J of Surg Pathol 2005;13:223–225.
Walfischa S, Lapida O, Yanai-Inbarb I, et al. Sigmoid colon carcinoma metastatic to the myometrium. Eur J Obstet Gynecol Reprod Biol 1999:86;65–68
Gottwald L, Piekarski J, Jeziorski A. The role of cytoreductive
surgery for non-genital tract metastases to the ovary. Transworld Research Network 2010:101-122
Kim WY, Kim TJ, Kim SE, et al. The role of cytoreductive
surgery for non-genital tract metastatic tumors to the ovaries. Eur J Obstet Gynecol Reprod Biol 2010;149;97–101
Becker SO, Tomacruz R, Kaufman KS, et al. Gynecologic abnormalities in surgically treated women with stage II or III rectal cancer. J Am Coll Surg 2002;194:315.
Falchook GS, Wolff RA, Varadhachary GR. Clinicopathologic
features and treatment strategies for patients with pancreatic adenocarcinoma and ovarian metastases. Gynecol Oncol 2008;108:515.

Details

Primary Language

Turkish

Subjects

-

Journal Section

-

Authors

Kemal Güngördük

Varol Gülseren This is me

Muzaffer Sancı This is me

Publication Date

January 3, 2016

Submission Date

January 3, 2016

Acceptance Date

-

Published in Issue

Year 2015 Volume: 6 Number: 4

DOI

https://doi.org/10.5799/ahinjs.01.2015.04.0559

IZ

https://izlik.org/JA68PZ99XS

Cite

RIS / Bibtex

APA

Güngördük, K., Gülseren, V., & Sancı, M. (2016). Current approach to metastasis of extra-genital system malignancies to the female genital tract. Journal of Clinical and Experimental Investigations, 6(4), 406-413. https://doi.org/10.5799/ahinjs.01.2015.04.0559

AMA

1.Güngördük K, Gülseren V, Sancı M. Current approach to metastasis of extra-genital system malignancies to the female genital tract. J Clin Exp Invest. 2016;6(4):406-413. doi:10.5799/ahinjs.01.2015.04.0559

Chicago

Güngördük, Kemal, Varol Gülseren, and Muzaffer Sancı. 2016. “Current Approach to Metastasis of Extra-Genital System Malignancies to the Female Genital Tract”. Journal of Clinical and Experimental Investigations 6 (4): 406-13. https://doi.org/10.5799/ahinjs.01.2015.04.0559.

EndNote

Güngördük K, Gülseren V, Sancı M (January 1, 2016) Current approach to metastasis of extra-genital system malignancies to the female genital tract. Journal of Clinical and Experimental Investigations 6 4 406–413.

IEEE

[1]K. Güngördük, V. Gülseren, and M. Sancı, “Current approach to metastasis of extra-genital system malignancies to the female genital tract”, J Clin Exp Invest, vol. 6, no. 4, pp. 406–413, Jan. 2016, doi: 10.5799/ahinjs.01.2015.04.0559.

ISNAD

Güngördük, Kemal - Gülseren, Varol - Sancı, Muzaffer. “Current Approach to Metastasis of Extra-Genital System Malignancies to the Female Genital Tract”. Journal of Clinical and Experimental Investigations 6/4 (January 1, 2016): 406-413. https://doi.org/10.5799/ahinjs.01.2015.04.0559.

JAMA

1.Güngördük K, Gülseren V, Sancı M. Current approach to metastasis of extra-genital system malignancies to the female genital tract. J Clin Exp Invest. 2016;6:406–413.

MLA

Güngördük, Kemal, et al. “Current Approach to Metastasis of Extra-Genital System Malignancies to the Female Genital Tract”. Journal of Clinical and Experimental Investigations, vol. 6, no. 4, Jan. 2016, pp. 406-13, doi:10.5799/ahinjs.01.2015.04.0559.

Vancouver

1.Kemal Güngördük, Varol Gülseren, Muzaffer Sancı. Current approach to metastasis of extra-genital system malignancies to the female genital tract. J Clin Exp Invest. 2016 Jan. 1;6(4):406-13. doi:10.5799/ahinjs.01.2015.04.0559