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Survival in Operated Early and Local Advanced-Stage (IA-IIIA) Non-Small Cell Lung Cancer

Year 2016, , 125 - 133, 10.06.2016
https://doi.org/10.5799/ahinjs.01.2016.02.0584

Abstract

ABSTRACT

Objective: The early and local advanced stages (IA-IIIA) of non-small cell lung cancer (NSCLC) warrant the curative treatment approach of surgery. However, despite the surgical approach, survival depends on a number of factors. The aim of the study was to examine the factors that affect survival in operated NSCLC patients with these stages.

Methods: A cohort of 231 operated patients with IA, IB, IIA, IIB, and IIIA stages of NSCLC were analyzed. The effects of age, sex, comorbidity, performance status, histopathology of the tumor, T stage, N stage, pleural invasion, surgical resection type and postoperative resection margin invasion on the survival of the patients were examined with Kaplan-Meier and Cox Regression analyses.

Results: Advanced age (OR=1.042 for every passing year, CI=1.020-1.064), adenocarcinoma histopathology (OR=1.676 CI=1.178-2.384), N2 invasion (OR=2.389 CI=1.46-4.239), pleural invasion (OR=2.403 CI=1.569-3.678), resection margin invasion (OR=2.401, CI=1.141-5.048) and pneumonectomy as the type of surgical operation (OR=2.313, CI=1.467-3.647) were found to be independent prognostic factors of mortality.

Conclusion: Follow-up of the NSCLC cases with advanced age, an adenocarcinoma type, visceral pleural invasion, N2-lymph node invasion, a history of pneumonectomy, and a resection margin invasion should be undertaken more atten­tively during planning of surgical operation and postoperative period. J Clin Exp Invest 2016; 7 (2): 125-133

Key words: Survival, mortality, performance score, operated, non-small cell lung cancer


References

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Zhonghua zhong liu za zhi [Chinese J Oncol]. 2009;31:465-8. 6. Oken MM, Creech RH, Tormey DC, et al. Toxicity and re - sponse criteria of the Eastern Cooperative Oncology Group. Am J Clin Oncol. 1982;5:649-6. 7. Goldstraw P. The 7 th Edition of TNM in Lung Cancer: what now? J Thoracic Surg Oncol. 2009;4:671-3. 8. Greenlee RT, Murray T, Bolden S, Wingo PA. Cancer statis - tics, 2000. CA Cancer J Clin. 2000;50:7-33. 9. Liu M, Cai X, Yu W, et al. Clinical significance of age at diagnosis among young non-small cell lung cancer patients under 40 years old: a population-based study. Oncotarget. 2015;6:44963-70 10. Radzikowska E, Glaz P, Roszkowski K. Lung cancer in women: age, smoking, histology, performance status, stage, initial treatment and survival. Population-based study of 20 561 cases. Ann Oncol. 2002;13:1087-93. 11. Radzikowska E, Głaz P, Roszkowski K. Lung cancer in women: age, smoking, histology, performance status, stage, initial treatment and survival. Population-based study of 20 561 cases. Ann Oncol. 2002;13:1087-93. 12. Visbal AL, Williams BA, Nichols FC, et al. Gender differ - ences in non–small-cell lung cancer survival: an analysis of 4,618 patients diagnosed between 1997 and 2002. Ann Thorac Surg. 2004;78:209-15. 13. Alexiou C, Onyeaka CV, Beggs D, et al. Do women live longer following lung resection for carcinoma? Eur J Car - diothorac Surg. 2002;21:319-25. 14. Kawaguchi T, Takada M, Kubo A, et al. Performance status and smoking status are independent favorable prognostic factors for survival in non-small cell lung cancer: a compre - hensive analysis of 26,957 patients with NSCLC. J Thorac Oncol. 2010;5:620-30. 15. Patz EF, Rossi S, Harpole DH, et al. Correlation of tumor size and survival in patients with stage IA non-small cell lung cancer. Chest. 2000;117:1568-71. 16. Harpole DH, Herndon JE, Young WG, et al. Stage I nons - mall cell lung cancer. A multivariate analysis of treatment methods and patterns of recurrence. Cancer. 1995;76:787- 96. 17. Ma Q, Liu D, Guo Y, et al. Surgical therapeutic strategy for non-small cell lung cancer with mediastinal lymph node metastasis (N2). Zhongguo Fei Ai Za Zhi. 2010;13:342-8. 18. Dai Y, Su XD, Long H, et al. Survival analysis of 220 pa - tients with completely resected stage-II non-small cell lung cancer. Chinese J Cancer. 2010;29:538-44. 19. Lakha S, Gomez JE, Flores RM, Wisnivesky JP. Prognostic significance of visceral pleural involvement in early-stage lung cancer. Chest. 2014;146:1619-26. 20. Kang JH, Kim KD, Chung KY. Prognostic value of visceral pleura invasion in non-small cell lung cancer. Eur J Cardio - thorac Surg. 2003;23:865-9. 21. Naito Y, Goto K, Nagai K, et al. Vascular invasion is a strong prognostic factor after complete resection of node-negative non-small cell lung cancer. Chest. 2010;138:1411-7. 22. Ruffini E, Asioli S, Filosso PL, et al. Significance of the presence of microscopic vascular invasion after complete resection of Stage I-II pT1-T2N0 non-small cell lung can - cer and its relation with T-Size categories: did the 2009 7th edition of the TNM staging system miss something? J Tho - rac Oncol. 2011;6:319-26. 23. Chandrachud L, Pendleton N, Chisholm D, et al. Relation - ship between vascularity, age and survival in non-small-cell lung cancer. Brit J Cancer. 1997;76:1367-70. 24. Naruke T, Tsuchiya R, Kondo H, Asamura H. Prognosis and survival after resection for bronchogenic carcinoma based on the 1997 TNM-staging classification: the Japanese expe - rience. Ann Thorac Surg. 2001;71:1759-64. 25. Kates M, Swanson S, Wisnivesky JP. Survival following lobectomy and limited resection for the treatment of stage I non-small cell lung cancer<=1 cm in size: a review of SEER data. Chest. 2011;139:491-6. 26. Kim DJ, Lee JG, Lee CY, et al. Long-term survival follow - ing pneumonectomy for non-small cell lung cancer: clinical implications for follow-up care. Chest. 2007;132:178-84. 27. Martini N, Bains MS, Burt ME, et al. Incidence of local recurrence and second primary tumors in resected stage I lung cancer. J Thorac Cardiovasc Surg. 1995;109:120-9. 28. Drukin E, Preis VG, Mikhnin AE, et al. [Analysis of one-year mortality of radically operated patients over 70 years with nonsmall cell lung cancer]. Voprosy Onkologii. 2014;60:88-93. 29. Ng CS, Lee TW, Wan S, et al. Thoracotomy is associated with significantly more profound suppression in lympho - cytes and natural killer cells than video-assisted thoracic surgery following major lung resections for cancer. J Invest Surg. 2005;18:81-8. 30. Poullis M, McShane J, Shaw M, et al. Bronchial resection margin and long-term survival in non-small-cell lung can - cer. Asian Cardiovasc Thorac Ann. 2012;20:432-8. 31. Yue D, Wang C. [Surgical resection standard and prognostic analysis of non-small cell lung cancer]. Zhonghua Zhong Liu Za Zhi. 2014;36:532-5.
Year 2016, , 125 - 133, 10.06.2016
https://doi.org/10.5799/ahinjs.01.2016.02.0584

Abstract

References

  • 1. Scott WJ, Howington J, Feigenberg S, et al. Treatment of non-small cell lung cancer stage I and stage II: ACCP evidence-based clinical practice guidelines (2 nd edition). Chest. 2007;132:234s-42s. 2. Birim O, Zuydendorp HM, Maat AP, et al. Lung resection for non-small-cell lung cancer in patients older than 70: mortality, morbidity, and late survival compared with the general population. Ann Thorac Surg. 2003;76:1796-801. 3. Thorsteinsson H, Alexandersson A, Oskarsdottir GN, et al. Resection rate and outcome of pulmonary resections for non-small-cell lung cancer: a nationwide study from Ice - land. J Thorac Oncol. 2012;7:1164-9. 4. Oskarsdottir GN, Skuladottir R, Isaksson HJ, et al. [Factors predictive of survival after lobectomy for non-small cell lung cancer in Iceland during 1999-2008]. Laeknabladid. 2010;96:251-7. 5. Yu DP, Bai LQ, Xu SF, et al. [Impact of TNM staging and treatment mode on the prognosis of non-small cell lung cancer]. Zhonghua zhong liu za zhi [Chinese J Oncol]. 2009;31:465-8. 6. Oken MM, Creech RH, Tormey DC, et al. Toxicity and re - sponse criteria of the Eastern Cooperative Oncology Group. Am J Clin Oncol. 1982;5:649-6. 7. Goldstraw P. The 7 th Edition of TNM in Lung Cancer: what now? J Thoracic Surg Oncol. 2009;4:671-3. 8. Greenlee RT, Murray T, Bolden S, Wingo PA. Cancer statis - tics, 2000. CA Cancer J Clin. 2000;50:7-33. 9. Liu M, Cai X, Yu W, et al. Clinical significance of age at diagnosis among young non-small cell lung cancer patients under 40 years old: a population-based study. Oncotarget. 2015;6:44963-70 10. Radzikowska E, Glaz P, Roszkowski K. Lung cancer in women: age, smoking, histology, performance status, stage, initial treatment and survival. Population-based study of 20 561 cases. Ann Oncol. 2002;13:1087-93. 11. Radzikowska E, Głaz P, Roszkowski K. Lung cancer in women: age, smoking, histology, performance status, stage, initial treatment and survival. Population-based study of 20 561 cases. Ann Oncol. 2002;13:1087-93. 12. Visbal AL, Williams BA, Nichols FC, et al. Gender differ - ences in non–small-cell lung cancer survival: an analysis of 4,618 patients diagnosed between 1997 and 2002. Ann Thorac Surg. 2004;78:209-15. 13. Alexiou C, Onyeaka CV, Beggs D, et al. Do women live longer following lung resection for carcinoma? Eur J Car - diothorac Surg. 2002;21:319-25. 14. Kawaguchi T, Takada M, Kubo A, et al. Performance status and smoking status are independent favorable prognostic factors for survival in non-small cell lung cancer: a compre - hensive analysis of 26,957 patients with NSCLC. J Thorac Oncol. 2010;5:620-30. 15. Patz EF, Rossi S, Harpole DH, et al. Correlation of tumor size and survival in patients with stage IA non-small cell lung cancer. Chest. 2000;117:1568-71. 16. Harpole DH, Herndon JE, Young WG, et al. Stage I nons - mall cell lung cancer. A multivariate analysis of treatment methods and patterns of recurrence. Cancer. 1995;76:787- 96. 17. Ma Q, Liu D, Guo Y, et al. Surgical therapeutic strategy for non-small cell lung cancer with mediastinal lymph node metastasis (N2). Zhongguo Fei Ai Za Zhi. 2010;13:342-8. 18. Dai Y, Su XD, Long H, et al. Survival analysis of 220 pa - tients with completely resected stage-II non-small cell lung cancer. Chinese J Cancer. 2010;29:538-44. 19. Lakha S, Gomez JE, Flores RM, Wisnivesky JP. Prognostic significance of visceral pleural involvement in early-stage lung cancer. Chest. 2014;146:1619-26. 20. Kang JH, Kim KD, Chung KY. Prognostic value of visceral pleura invasion in non-small cell lung cancer. Eur J Cardio - thorac Surg. 2003;23:865-9. 21. Naito Y, Goto K, Nagai K, et al. Vascular invasion is a strong prognostic factor after complete resection of node-negative non-small cell lung cancer. Chest. 2010;138:1411-7. 22. Ruffini E, Asioli S, Filosso PL, et al. Significance of the presence of microscopic vascular invasion after complete resection of Stage I-II pT1-T2N0 non-small cell lung can - cer and its relation with T-Size categories: did the 2009 7th edition of the TNM staging system miss something? J Tho - rac Oncol. 2011;6:319-26. 23. Chandrachud L, Pendleton N, Chisholm D, et al. Relation - ship between vascularity, age and survival in non-small-cell lung cancer. Brit J Cancer. 1997;76:1367-70. 24. Naruke T, Tsuchiya R, Kondo H, Asamura H. Prognosis and survival after resection for bronchogenic carcinoma based on the 1997 TNM-staging classification: the Japanese expe - rience. Ann Thorac Surg. 2001;71:1759-64. 25. Kates M, Swanson S, Wisnivesky JP. Survival following lobectomy and limited resection for the treatment of stage I non-small cell lung cancer<=1 cm in size: a review of SEER data. Chest. 2011;139:491-6. 26. Kim DJ, Lee JG, Lee CY, et al. Long-term survival follow - ing pneumonectomy for non-small cell lung cancer: clinical implications for follow-up care. Chest. 2007;132:178-84. 27. Martini N, Bains MS, Burt ME, et al. Incidence of local recurrence and second primary tumors in resected stage I lung cancer. J Thorac Cardiovasc Surg. 1995;109:120-9. 28. Drukin E, Preis VG, Mikhnin AE, et al. [Analysis of one-year mortality of radically operated patients over 70 years with nonsmall cell lung cancer]. Voprosy Onkologii. 2014;60:88-93. 29. Ng CS, Lee TW, Wan S, et al. Thoracotomy is associated with significantly more profound suppression in lympho - cytes and natural killer cells than video-assisted thoracic surgery following major lung resections for cancer. J Invest Surg. 2005;18:81-8. 30. Poullis M, McShane J, Shaw M, et al. Bronchial resection margin and long-term survival in non-small-cell lung can - cer. Asian Cardiovasc Thorac Ann. 2012;20:432-8. 31. Yue D, Wang C. [Surgical resection standard and prognostic analysis of non-small cell lung cancer]. Zhonghua Zhong Liu Za Zhi. 2014;36:532-5.
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Details

Subjects Health Care Administration
Journal Section Research Article
Authors

Mahsuk Taylan

Publication Date June 10, 2016
Published in Issue Year 2016

Cite

APA Taylan, M. (2016). Survival in Operated Early and Local Advanced-Stage (IA-IIIA) Non-Small Cell Lung Cancer. Journal of Clinical and Experimental Investigations, 7(2), 125-133. https://doi.org/10.5799/ahinjs.01.2016.02.0584
AMA Taylan M. Survival in Operated Early and Local Advanced-Stage (IA-IIIA) Non-Small Cell Lung Cancer. J Clin Exp Invest. June 2016;7(2):125-133. doi:10.5799/ahinjs.01.2016.02.0584
Chicago Taylan, Mahsuk. “Survival in Operated Early and Local Advanced-Stage (IA-IIIA) Non-Small Cell Lung Cancer”. Journal of Clinical and Experimental Investigations 7, no. 2 (June 2016): 125-33. https://doi.org/10.5799/ahinjs.01.2016.02.0584.
EndNote Taylan M (June 1, 2016) Survival in Operated Early and Local Advanced-Stage (IA-IIIA) Non-Small Cell Lung Cancer. Journal of Clinical and Experimental Investigations 7 2 125–133.
IEEE M. Taylan, “Survival in Operated Early and Local Advanced-Stage (IA-IIIA) Non-Small Cell Lung Cancer”, J Clin Exp Invest, vol. 7, no. 2, pp. 125–133, 2016, doi: 10.5799/ahinjs.01.2016.02.0584.
ISNAD Taylan, Mahsuk. “Survival in Operated Early and Local Advanced-Stage (IA-IIIA) Non-Small Cell Lung Cancer”. Journal of Clinical and Experimental Investigations 7/2 (June 2016), 125-133. https://doi.org/10.5799/ahinjs.01.2016.02.0584.
JAMA Taylan M. Survival in Operated Early and Local Advanced-Stage (IA-IIIA) Non-Small Cell Lung Cancer. J Clin Exp Invest. 2016;7:125–133.
MLA Taylan, Mahsuk. “Survival in Operated Early and Local Advanced-Stage (IA-IIIA) Non-Small Cell Lung Cancer”. Journal of Clinical and Experimental Investigations, vol. 7, no. 2, 2016, pp. 125-33, doi:10.5799/ahinjs.01.2016.02.0584.
Vancouver Taylan M. Survival in Operated Early and Local Advanced-Stage (IA-IIIA) Non-Small Cell Lung Cancer. J Clin Exp Invest. 2016;7(2):125-33.