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The Success of the Single-Dose Methotrexate Treatment in an Atypical Heterotopic Pregnancy

Year 2016, , 200 - 202, 16.06.2016
https://doi.org/10.5799/ahinjs.01.2016.02.0597

Abstract

Heterotopic pregnancy refers to simultaneous presence of intrauterine
and ectopic gestational sacs. Its incidence ex­hibits a rising trend due
to the increased use of assisted reproductive technology (ART). This
paper aims to present a rare case of tubal and cesarean scar heterotopic
pregnancy that occurred following a spontaneous pregnancy. The pa­tient
presenting with delayed menstruation and abdominal-inguinal pain was
evaluated. Transvaginal ultrasonography revealed a gestational sac
located in the scar of a previous cesarean section and in the left tubal
region corresponding to a gestational age of 4 weeks and 5 days. The
patient was hospitalized and informed about conservative and surgi­cal
methods. Then, she was administered a single dose of methotrexate 75 mg
intramuscularly. Post-operative period included ultrasonographic and
laboratory follow-up. In conclusion, it should be remembered that
single-dose systemic methotrexate therapy might constitute an
alternative to surgery in unruptured hemodynamically stable cases. J Clin Exp Invest 2016; 7 (2): 200-202

References

  • 1. Evsen MS, Soydinç HE. Acil jinekolojik operasyonlar: 105 olgunun değerlendirilmesi. J Clin Exp Invest. 2010;1:12-5. 2. Telci S, Kaya C, Yasar L, Ekin M. Spontaneous heterotopic pregnancy causing tubal rupture in a patient with intrauter - ine device in-situ. Bakırköy Tıp Dergisi 2014;10:121-123. 3. Luo X, Lim CE, Huang C, et al. Heterotopic pregnancy fol - lowing in vitro fertilization and embryo transfer: 12 cases report. Arch Gynecol Obste. 2009;280:325-9. 4. Hassiakos D, Bakas P, Pistofidis G, Creatsas G. Hetero - topic pregnancy at 16 weeks of gestation after in-vitro fertilization and embryo transfer. Arch Gynecol Obstet. 2002;266:124-5. 5. Tal J, Haddad S, Gordon N, Timor-Tritsch I. Heterotopic pregnancy after ovulation induction and assisted reproduc - tive technologies: a literature review from 1971-1993. Fer - til Steril. 1996;66:1-12. 6. Arıöz DT, Çelik F, Polat C. Heterotopik gebelik: Olağandışı bir akut batin nedeni. Kocatepe Tıp Dergisi. 2008;9:1-3. 7. Seidman DS, Levran D, Ben-Rafael Z, et al. The incidence of combined intrauterine and extrauterine pregnancy af - ter in vitro fertilization and embryo transfer. Fertil Steril. 1991;55:833-4. 8. Reece ED, Petrie RH, Sirmons MF, et al. Combined intra - uterine and extrauterine gestation: a review. Am J Obstet Gynecol. 1983;146:323-330. 9. Glassner MJ, Aron E, Eskin BA. Ovulation induction with clomiphene and rise in heterotopic pregnancies: a report of two cases. J Reprod Med. 1990;35:175-178. 10. Lavanya R, Deepika K, Madhuri P. Successful pregnancy following medical management of heterotopic pregnancy. J Hum Reprod Sci. 2009;2:35-40. 11. Baxi A, Kaushal M, Karmalkar H, et al. Successful expect - ant management of tubal heterotopic pregnancy. J Hum Re - prod Sci. 2010;3:108-10. 12. Parker J, Thompson D. Persistent ectopic pregnancy after conservation management successful treatment with single- dose intramusculer MTX. Obstet Gynecol. 1994;34:99-102. 13. Lipscomb GH, McCord Ml, Stovall TG, et al. Predictors of success of methotrexate treatment in women with tubal ectopic preganancies. N Engl J Med. 1999;341:1974-8. 14. The American College of Obstetricians and Gynecologists Medical management of tubal pregnancy. Clinical Manage - ment Guidelines, 1998; Number 3. 15. Barnhart KT, Gosman G, Ashby R, Sammel M. The medical management of ectopic pregnancy: a meta analysis compar - ing’ single dose and multidose’ regimens. Obstet Gynecol. 2003;101:778-84.
Year 2016, , 200 - 202, 16.06.2016
https://doi.org/10.5799/ahinjs.01.2016.02.0597

Abstract

References

  • 1. Evsen MS, Soydinç HE. Acil jinekolojik operasyonlar: 105 olgunun değerlendirilmesi. J Clin Exp Invest. 2010;1:12-5. 2. Telci S, Kaya C, Yasar L, Ekin M. Spontaneous heterotopic pregnancy causing tubal rupture in a patient with intrauter - ine device in-situ. Bakırköy Tıp Dergisi 2014;10:121-123. 3. Luo X, Lim CE, Huang C, et al. Heterotopic pregnancy fol - lowing in vitro fertilization and embryo transfer: 12 cases report. Arch Gynecol Obste. 2009;280:325-9. 4. Hassiakos D, Bakas P, Pistofidis G, Creatsas G. Hetero - topic pregnancy at 16 weeks of gestation after in-vitro fertilization and embryo transfer. Arch Gynecol Obstet. 2002;266:124-5. 5. Tal J, Haddad S, Gordon N, Timor-Tritsch I. Heterotopic pregnancy after ovulation induction and assisted reproduc - tive technologies: a literature review from 1971-1993. Fer - til Steril. 1996;66:1-12. 6. Arıöz DT, Çelik F, Polat C. Heterotopik gebelik: Olağandışı bir akut batin nedeni. Kocatepe Tıp Dergisi. 2008;9:1-3. 7. Seidman DS, Levran D, Ben-Rafael Z, et al. The incidence of combined intrauterine and extrauterine pregnancy af - ter in vitro fertilization and embryo transfer. Fertil Steril. 1991;55:833-4. 8. Reece ED, Petrie RH, Sirmons MF, et al. Combined intra - uterine and extrauterine gestation: a review. Am J Obstet Gynecol. 1983;146:323-330. 9. Glassner MJ, Aron E, Eskin BA. Ovulation induction with clomiphene and rise in heterotopic pregnancies: a report of two cases. J Reprod Med. 1990;35:175-178. 10. Lavanya R, Deepika K, Madhuri P. Successful pregnancy following medical management of heterotopic pregnancy. J Hum Reprod Sci. 2009;2:35-40. 11. Baxi A, Kaushal M, Karmalkar H, et al. Successful expect - ant management of tubal heterotopic pregnancy. J Hum Re - prod Sci. 2010;3:108-10. 12. Parker J, Thompson D. Persistent ectopic pregnancy after conservation management successful treatment with single- dose intramusculer MTX. Obstet Gynecol. 1994;34:99-102. 13. Lipscomb GH, McCord Ml, Stovall TG, et al. Predictors of success of methotrexate treatment in women with tubal ectopic preganancies. N Engl J Med. 1999;341:1974-8. 14. The American College of Obstetricians and Gynecologists Medical management of tubal pregnancy. Clinical Manage - ment Guidelines, 1998; Number 3. 15. Barnhart KT, Gosman G, Ashby R, Sammel M. The medical management of ectopic pregnancy: a meta analysis compar - ing’ single dose and multidose’ regimens. Obstet Gynecol. 2003;101:778-84.
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Details

Subjects Health Care Administration
Journal Section Short Report
Authors

Serdar Başaranoğlu This is me

Publication Date June 16, 2016
Published in Issue Year 2016

Cite

APA Başaranoğlu, S. (2016). The Success of the Single-Dose Methotrexate Treatment in an Atypical Heterotopic Pregnancy. Journal of Clinical and Experimental Investigations, 7(2), 200-202. https://doi.org/10.5799/ahinjs.01.2016.02.0597
AMA Başaranoğlu S. The Success of the Single-Dose Methotrexate Treatment in an Atypical Heterotopic Pregnancy. J Clin Exp Invest. June 2016;7(2):200-202. doi:10.5799/ahinjs.01.2016.02.0597
Chicago Başaranoğlu, Serdar. “The Success of the Single-Dose Methotrexate Treatment in an Atypical Heterotopic Pregnancy”. Journal of Clinical and Experimental Investigations 7, no. 2 (June 2016): 200-202. https://doi.org/10.5799/ahinjs.01.2016.02.0597.
EndNote Başaranoğlu S (June 1, 2016) The Success of the Single-Dose Methotrexate Treatment in an Atypical Heterotopic Pregnancy. Journal of Clinical and Experimental Investigations 7 2 200–202.
IEEE S. Başaranoğlu, “The Success of the Single-Dose Methotrexate Treatment in an Atypical Heterotopic Pregnancy”, J Clin Exp Invest, vol. 7, no. 2, pp. 200–202, 2016, doi: 10.5799/ahinjs.01.2016.02.0597.
ISNAD Başaranoğlu, Serdar. “The Success of the Single-Dose Methotrexate Treatment in an Atypical Heterotopic Pregnancy”. Journal of Clinical and Experimental Investigations 7/2 (June 2016), 200-202. https://doi.org/10.5799/ahinjs.01.2016.02.0597.
JAMA Başaranoğlu S. The Success of the Single-Dose Methotrexate Treatment in an Atypical Heterotopic Pregnancy. J Clin Exp Invest. 2016;7:200–202.
MLA Başaranoğlu, Serdar. “The Success of the Single-Dose Methotrexate Treatment in an Atypical Heterotopic Pregnancy”. Journal of Clinical and Experimental Investigations, vol. 7, no. 2, 2016, pp. 200-2, doi:10.5799/ahinjs.01.2016.02.0597.
Vancouver Başaranoğlu S. The Success of the Single-Dose Methotrexate Treatment in an Atypical Heterotopic Pregnancy. J Clin Exp Invest. 2016;7(2):200-2.