The Relationship of Vitamin B12 Deficiency and Red Cell Distribution Width-Platelet Ratio

Year 2016, , 211 - 213, 01.09.2016

Nigar Yılmaz Mustafa Yılmaz

https://doi.org/10.5799/jcei.328604

Abstract

Objective: We aimed to investigate the relationship between vitamin B12 deficiency and red cell distribution widthplatelet
ratio (RPR), and the variations in the parameters on vitamin B12 treatment.
Methods: One hundred fifty-four patients with untreated vitamin B12 deficiency (56% men, mean age: 50 ± 12.7 years)
(untreated group), 86 patients with vitamin B12 deficiency (62% men, mean age: 42 ± 20.7 years) on vitamin B12 treatment
(treated group), and 92 age- and sex-matched control group (54% men, mean age: 45 ± 15.1 years) were included
in the study. Hematological parameters were evaluated by the method of laser-based flow cytometric impedance, using
an automated blood cell counter (ABX Pentra 120 Hematology Blood Analyzer).
Results: RPR was significantly reduced in treated group compared with untreated group (4.88 ± 1.06; 6.13 ± 1.27;
p<0.001, respectively). RPR, red cell distribution width (RDW) and mean platelet volume (MPV) were significantly different
in untreated group compared to controls (p<0.05). There were no differences in platelet count in the three groups
(p>0.05).
Conclusion: We proposed that vitamin B12 deficiency has effects on RPR and supplementation with vitamin B12 corrects
the RPR levels. J Clin Exp Invest 2016; 7 (3): 211-215

Keywords

Vitamin B12 deficiency, red cell distribution width-platelet ratio, vitamin B12 treatment, Mean platelet volume

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