Research Article
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Year 2016, , 7 - 13, 01.03.2016
https://doi.org/10.5799/jcei.328658

Abstract

References

  • 1. Duffy S. Chronic pelvic pain: defining the scope of the problem (2001) Int J Gynaecol Obstet 2001;74:3-7.
  • 2. Palomba S, Russo T, Falbo A, et al. Laparoscopic uterine nerve ablation versus vaginal uterosacral ligament resection in postmenopausal women with intractable midline chronic pelvic pain: A randomized study. Eur J Obstet Gynecol Reprod Biol 2006;129:84–91.
  • 3. Zondervan KT, Yudkin PL, Vessey MP, et al. Chronic pelvic pain in the community symptoms, investigation, and diagnoses. Am J Obstet Gynecol 2001;184:1149–1155.
  • 4. Stein SL. Chronic pelvic pain. Gastroenterol Clin North Am 2013;42:785-800.
  • 5. Weijenborg PT, Greeven A, Dekker FW, et al. Clinical course of chronic pelvic pain in women. Pain 2007;132:117–123.
  • 6. Porpora MG, Gomel V. The role of laparoscopy in the management of pelvic pain in women of reproductive age. Fertil Steril 1997;68:765–779.
  • 7. Carter JE. Surgical treatment for chronic pelvic pain. JSLS 1998;2:129–139.
  • 8. Sharma D, Dahiya K, Duhan N, Bansal R. Diagnostic laparoscopy in chronic pelvic pain. Arch Gynecol Obstet 2011;283:295-297
  • 9. Demir F, Ozcimen EE, Oral HB. The role of gynecological, urological, and psychiatric factors in chronic pelvic pain. Arch Gynecol Obstet 2012;286:1215-1220.
  • 10. Frankenhauser G. Die Bewegungenerven der Gebarmutter. Z Med Nat Wiss 1864;1:35.
  • 11. Johnson NP, Farquar CM, Crossley S, et al. A doubleblind randomized controlled trial of laparoscopic uterine nerve ablation for women with chronic pelvic pain. BJOG 2004;111:950–959.
  • 12. Daniels J, Gray R, Khan KS, Gupta J. Laparoscopic uterine nevre ablation: a survey of gynaecological practice in UK. Gynecol Endosc 2000;9:157–159.
  • 13. Davis GD. Uterine prolapse after laparoscopic uterosacral transection in nulliparous airborne trainees: a report of three cases. J Reprod Med 1986;41:279-282.
  • 14. Patt RB. Cancer pain. In Patt RB(ed):Cancer Pain. Lippincott, Philadelphia, 1993, pp377-425.
  • 15. Rowe DS. Neurolytic techniques for pain management. Pain Clin 1995; 8:107-115.
  • 16. Mathias SD, Kuppermann M, Liberman RF, et al. Chronic pelvic pain: prevalence, health-related quality of life, and economic correlates. Obstet Gynecol 1996;87:321–327.
  • 17. Kresch AJ, Seifer DB, Sachs LB, Barrese I Laparoscopy in the evalution of 100 women with chronic pelvic pain. Obstet Gynecol 1984;64:672.
  • 18. Vercellini P, Fedele L, Molteni P, et al. Laparoscopy in the diagnosis of gynecologic chronic pelvic pain. Int J Gynaecol Obstet 1990;32:261-265.
  • 19. Levitan Z, Eibschitz I, de Vries K, et al. The value of laparoscopy in women with chronic pelvic pain and a “normal pelvis”. Int J Gynaecol Obstet 1985;23:71-74.
  • 20. Florido J, Pérez-Lucas R, Navarrete L. Sexual behavior and findings on laparoscopy or laparotomy in women with severe chronic pelvic pain. Eur J Obstet Gynecol Reprod Biol 2008;139:233-236.
  • 21. Drozgyik I, Vizer M, Szabo. Significance of laparoscopy in the management of chronic pelvic pain. Eur J Obstet Gynecol Reprod Biol 2007;133:223-226
  • 22. Cox L, Ayers S, Nala K, Penny J. Chronic pelvic pain and quality of life after laparoscopy. Eur J Obstet Gynecol Reprod Biol 2007;132:214-219
  • 23. Kontoravdis A, Chryssikopoulos A, Hassiakos D, et al. The diagnostic value of laparoscopy in 2365 patients with acut and chronic pelvic pain. Int J Gynecol Obstet 1996;52;243- 248.
  • 24. Carter JE. Laparoscopic finding in patients with chronic pelvic pain. J Am Assoc Gynecol Laparoscopy 1994;2:43-47.
  • 25. Roseff SJ, Murphy AA. Laparoscopy in the diagnosis and therapy of chronic pelvic pain. Clin Obstet Gynecol 1990;33:137-141.
  • 26. Cheong YC, Reading I, Bailey S, et al. Should women with chronic pelvic pain have adhesiolysis? BMC Womens Health 2014;14:36.
  • 27. Cornillie FJ, Oosterlynck D, Lauweryns J, Konnicks PR. Deeply infiltrating pelvic endometriosis; histology and clinical significance. Fertil Steril 1993;53:978-983.
  • 28. Cheong YC, Smotra G, Williams AC (2014) Non-surgical interventions for the management of chronic pelvic pain. Cochrane Database Syst Rev 2014 5;3: CD008797.
  • 29. De Leon-Casasola OA, Kent E, Lema MJ. Neurolytic superior hypogastric plexus block for chronic pelvic pain associated with cancer. Pain 1993;54:145–151.
  • 30. Pollitt CI, Salota V, Leschinskiy D. Chemical neurolysis of the superior hypogastric plexus for chronic non-cancer pelvic pain. Int J Gynaecol Obstet 2011;114:160-161.
  • 31. Walid MS, Heaton RL. Neurolysis with alcohol for deep dyspareunia caused by trigger points in the uterosacral stumps. J Minim Invasive Gynecol 2009;16:485-486.
  • 32. Singler RC. An improved technique for alcohol neurolysis of the celiac plexus. Anesthesiology 1982;56:137-141.

Laparoscopic Uterine Nerve Ethanol Neurolysis (LUNEN) in Patients with Chronic Pelvic Pain

Year 2016, , 7 - 13, 01.03.2016
https://doi.org/10.5799/jcei.328658

Abstract

Objective: To investigate the efficacy of laparoscopic uterine nerve ethanol neurolysis (LUNEN) for pain management
in patients with chronic pelvic pain (CPP).
Methods: LUNEN, as a chemical neurolysis procedure, was performed on 22 subjects, and these were compared with
20 controls that had a diagnostic laparoscopy alone. Pre-treatment and postoperative 6th month Visual Analogue Scale
(VAS) scores were estimated and a subjective pain evaluation questioning patients’ satisfaction about pain relief in the
6th month after surgery was also performed.
Results: A total of 31 (73.8%) out of 42 CPP patients had a laparoscopic pelvic pathology. Preoperative VAS scores were
similar in the groups; however, the mean postoperative VAS score was significantly lower in the LUNEN group than in
the control group (3.18 ± 2.88 vs. 5.35 ± 3.09; p=0.02). In the LUNEN group, the number of patients who stated that their
pain was relieved partially or completely was also significantly higher than in the control group (82% vs. 40%, p=0.019).
Conclusion: LUNEN is a feasible, safe and effective surgical alternative to traditional surgical methods in patients suffering
from CPP. J Clin Exp Invest 2016; 7 (1): 7-13

References

  • 1. Duffy S. Chronic pelvic pain: defining the scope of the problem (2001) Int J Gynaecol Obstet 2001;74:3-7.
  • 2. Palomba S, Russo T, Falbo A, et al. Laparoscopic uterine nerve ablation versus vaginal uterosacral ligament resection in postmenopausal women with intractable midline chronic pelvic pain: A randomized study. Eur J Obstet Gynecol Reprod Biol 2006;129:84–91.
  • 3. Zondervan KT, Yudkin PL, Vessey MP, et al. Chronic pelvic pain in the community symptoms, investigation, and diagnoses. Am J Obstet Gynecol 2001;184:1149–1155.
  • 4. Stein SL. Chronic pelvic pain. Gastroenterol Clin North Am 2013;42:785-800.
  • 5. Weijenborg PT, Greeven A, Dekker FW, et al. Clinical course of chronic pelvic pain in women. Pain 2007;132:117–123.
  • 6. Porpora MG, Gomel V. The role of laparoscopy in the management of pelvic pain in women of reproductive age. Fertil Steril 1997;68:765–779.
  • 7. Carter JE. Surgical treatment for chronic pelvic pain. JSLS 1998;2:129–139.
  • 8. Sharma D, Dahiya K, Duhan N, Bansal R. Diagnostic laparoscopy in chronic pelvic pain. Arch Gynecol Obstet 2011;283:295-297
  • 9. Demir F, Ozcimen EE, Oral HB. The role of gynecological, urological, and psychiatric factors in chronic pelvic pain. Arch Gynecol Obstet 2012;286:1215-1220.
  • 10. Frankenhauser G. Die Bewegungenerven der Gebarmutter. Z Med Nat Wiss 1864;1:35.
  • 11. Johnson NP, Farquar CM, Crossley S, et al. A doubleblind randomized controlled trial of laparoscopic uterine nerve ablation for women with chronic pelvic pain. BJOG 2004;111:950–959.
  • 12. Daniels J, Gray R, Khan KS, Gupta J. Laparoscopic uterine nevre ablation: a survey of gynaecological practice in UK. Gynecol Endosc 2000;9:157–159.
  • 13. Davis GD. Uterine prolapse after laparoscopic uterosacral transection in nulliparous airborne trainees: a report of three cases. J Reprod Med 1986;41:279-282.
  • 14. Patt RB. Cancer pain. In Patt RB(ed):Cancer Pain. Lippincott, Philadelphia, 1993, pp377-425.
  • 15. Rowe DS. Neurolytic techniques for pain management. Pain Clin 1995; 8:107-115.
  • 16. Mathias SD, Kuppermann M, Liberman RF, et al. Chronic pelvic pain: prevalence, health-related quality of life, and economic correlates. Obstet Gynecol 1996;87:321–327.
  • 17. Kresch AJ, Seifer DB, Sachs LB, Barrese I Laparoscopy in the evalution of 100 women with chronic pelvic pain. Obstet Gynecol 1984;64:672.
  • 18. Vercellini P, Fedele L, Molteni P, et al. Laparoscopy in the diagnosis of gynecologic chronic pelvic pain. Int J Gynaecol Obstet 1990;32:261-265.
  • 19. Levitan Z, Eibschitz I, de Vries K, et al. The value of laparoscopy in women with chronic pelvic pain and a “normal pelvis”. Int J Gynaecol Obstet 1985;23:71-74.
  • 20. Florido J, Pérez-Lucas R, Navarrete L. Sexual behavior and findings on laparoscopy or laparotomy in women with severe chronic pelvic pain. Eur J Obstet Gynecol Reprod Biol 2008;139:233-236.
  • 21. Drozgyik I, Vizer M, Szabo. Significance of laparoscopy in the management of chronic pelvic pain. Eur J Obstet Gynecol Reprod Biol 2007;133:223-226
  • 22. Cox L, Ayers S, Nala K, Penny J. Chronic pelvic pain and quality of life after laparoscopy. Eur J Obstet Gynecol Reprod Biol 2007;132:214-219
  • 23. Kontoravdis A, Chryssikopoulos A, Hassiakos D, et al. The diagnostic value of laparoscopy in 2365 patients with acut and chronic pelvic pain. Int J Gynecol Obstet 1996;52;243- 248.
  • 24. Carter JE. Laparoscopic finding in patients with chronic pelvic pain. J Am Assoc Gynecol Laparoscopy 1994;2:43-47.
  • 25. Roseff SJ, Murphy AA. Laparoscopy in the diagnosis and therapy of chronic pelvic pain. Clin Obstet Gynecol 1990;33:137-141.
  • 26. Cheong YC, Reading I, Bailey S, et al. Should women with chronic pelvic pain have adhesiolysis? BMC Womens Health 2014;14:36.
  • 27. Cornillie FJ, Oosterlynck D, Lauweryns J, Konnicks PR. Deeply infiltrating pelvic endometriosis; histology and clinical significance. Fertil Steril 1993;53:978-983.
  • 28. Cheong YC, Smotra G, Williams AC (2014) Non-surgical interventions for the management of chronic pelvic pain. Cochrane Database Syst Rev 2014 5;3: CD008797.
  • 29. De Leon-Casasola OA, Kent E, Lema MJ. Neurolytic superior hypogastric plexus block for chronic pelvic pain associated with cancer. Pain 1993;54:145–151.
  • 30. Pollitt CI, Salota V, Leschinskiy D. Chemical neurolysis of the superior hypogastric plexus for chronic non-cancer pelvic pain. Int J Gynaecol Obstet 2011;114:160-161.
  • 31. Walid MS, Heaton RL. Neurolysis with alcohol for deep dyspareunia caused by trigger points in the uterosacral stumps. J Minim Invasive Gynecol 2009;16:485-486.
  • 32. Singler RC. An improved technique for alcohol neurolysis of the celiac plexus. Anesthesiology 1982;56:137-141.
There are 32 citations in total.

Details

Subjects Health Care Administration
Journal Section Research Article
Authors

Seyhan Sönmez This is me

Ümit Naykı This is me

Paşa Uluğ This is me

Cenk Naykı This is me

Ferhan Sönmez This is me

Şivekar Tınar This is me

Yusuf Yıldırım This is me

Publication Date March 1, 2016
Published in Issue Year 2016

Cite

APA Sönmez, S., Naykı, Ü., Uluğ, P., Naykı, C., et al. (2016). Laparoscopic Uterine Nerve Ethanol Neurolysis (LUNEN) in Patients with Chronic Pelvic Pain. Journal of Clinical and Experimental Investigations, 7(1), 7-13. https://doi.org/10.5799/jcei.328658
AMA Sönmez S, Naykı Ü, Uluğ P, Naykı C, Sönmez F, Tınar Ş, Yıldırım Y. Laparoscopic Uterine Nerve Ethanol Neurolysis (LUNEN) in Patients with Chronic Pelvic Pain. J Clin Exp Invest. March 2016;7(1):7-13. doi:10.5799/jcei.328658
Chicago Sönmez, Seyhan, Ümit Naykı, Paşa Uluğ, Cenk Naykı, Ferhan Sönmez, Şivekar Tınar, and Yusuf Yıldırım. “Laparoscopic Uterine Nerve Ethanol Neurolysis (LUNEN) in Patients With Chronic Pelvic Pain”. Journal of Clinical and Experimental Investigations 7, no. 1 (March 2016): 7-13. https://doi.org/10.5799/jcei.328658.
EndNote Sönmez S, Naykı Ü, Uluğ P, Naykı C, Sönmez F, Tınar Ş, Yıldırım Y (March 1, 2016) Laparoscopic Uterine Nerve Ethanol Neurolysis (LUNEN) in Patients with Chronic Pelvic Pain. Journal of Clinical and Experimental Investigations 7 1 7–13.
IEEE S. Sönmez, “Laparoscopic Uterine Nerve Ethanol Neurolysis (LUNEN) in Patients with Chronic Pelvic Pain”, J Clin Exp Invest, vol. 7, no. 1, pp. 7–13, 2016, doi: 10.5799/jcei.328658.
ISNAD Sönmez, Seyhan et al. “Laparoscopic Uterine Nerve Ethanol Neurolysis (LUNEN) in Patients With Chronic Pelvic Pain”. Journal of Clinical and Experimental Investigations 7/1 (March 2016), 7-13. https://doi.org/10.5799/jcei.328658.
JAMA Sönmez S, Naykı Ü, Uluğ P, Naykı C, Sönmez F, Tınar Ş, Yıldırım Y. Laparoscopic Uterine Nerve Ethanol Neurolysis (LUNEN) in Patients with Chronic Pelvic Pain. J Clin Exp Invest. 2016;7:7–13.
MLA Sönmez, Seyhan et al. “Laparoscopic Uterine Nerve Ethanol Neurolysis (LUNEN) in Patients With Chronic Pelvic Pain”. Journal of Clinical and Experimental Investigations, vol. 7, no. 1, 2016, pp. 7-13, doi:10.5799/jcei.328658.
Vancouver Sönmez S, Naykı Ü, Uluğ P, Naykı C, Sönmez F, Tınar Ş, Yıldırım Y. Laparoscopic Uterine Nerve Ethanol Neurolysis (LUNEN) in Patients with Chronic Pelvic Pain. J Clin Exp Invest. 2016;7(1):7-13.