Benign Endometrial Polyp and Primary Endometrial Small Cell Neuroendocrine Carcinoma Confined to the Polyp: A Rare Association

Year 2016, , 106 - 109, 01.03.2016

Pembe Oltulu , Ceyhan Uğurluoğlu Ayşenur Uğur , Sıdıka Fındık , Lema Tavlı

https://doi.org/10.5799/jcei.328701

Abstract

Neuroendocrine tumors (NETs) are a heterogeneous group of tumoral lesions originating from diffuse endocrine system
cells. They occur mostly in the gastrointestinal system and the lung. Primary NETs of the female reproductive tract are
rare. In a widely used classification, primary small cell neuroendocrine carcinomas (SCNECs) and large cell neuroendocrine
carcinomas (LCNECs) of the endometrium were included in a subgroup of poorly differentiated neuroendocrine
carcinomas. SCNECs of the endometrium are very rare and they are often combined with other epithelial neoplasms.
Their myometrial and extrauterine invasions are common during the initial diagnosis due to their aggressive behaviors.
In this article, we present a rare case of primary endometrial SCNEC detected within the benign endometrial polyp and
without invasion of myometrium and extrauterine tissues in a 70-year-old female patient presenting with postmenopausal
bleeding. Histopathologically, the tumor cells showed positive staining with Synaptophysin, the Ki-67 labeling
index was 80-90%, the mitotic index was 15/10 per HPF and there was no necrosis and lymphovascular invasion. J Clin
Exp Invest 2016; 7 (1): 106-109

Keywords

Small cell carcinoma, endometrial polyp, neuroendocrine tumor, endometrium

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