Case Report
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Year 2017, , 35 - 38, 31.03.2017
https://doi.org/10.5799/jcei.328751

Abstract

References

  • 1. Swerdlow SH, Campo E, Harris NL, et al. WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues. Geneva: WHO Press, 2008.
  • 2. Wang HW, Yang W, Sun JZ, Lu JY, Li M, Sun L. Plasmablastic lymphoma of the small intestine: Case report and literature review. World J Gastroenterol. 2012;18(45):6677-81.
  • 3. Hashimoto M, Inaguma S, Kasai K, et al. Plasmablastic lymphoma of the stomach in an HIV-negative patient. Pathol Int. 2012;62(11):763- 70.
  • 4. Rafaniello RP, Pruneri G, Maiorano E. Plasmablastic lymphoma: a review. Oral Dis. 2009;15:38-45.
  • 5. Castillo JJ, Reagan JL. Plasmablastic Lymphoma: A Systematic Review. Sci World J. 2011;11:687- 96.
  • 6. Medeiros, LJ (ed). Diagnostic Pathology: Lymph Nodes and Spleen with Extranodal Lymphomas, 1st edn. Salt Lake City: Amirsys, 2011.
  • 7. Angeleri A, Rocher AE, Myburg C, Avagnina A, Aparo V, Palaoro LA. Plasmablastic lymphoma involving the stomach in an HIV-positive man. Cytopathology. 2016;27(4):293-5.
  • 8. Delecluse HJ, Anagnostopoulos I, Dallenbach F, et al. Plasmablastic lymphomas of the oral cavity: a new entity associated with the human immunodeficiency virus infection. Blood. 1997;89(4):1413-20.
  • 9. Suzuki Y, Yoshida T, Nakamura N, et al. CD3- and CD4-Positive Plasmablastic Lymphoma: A Literature Review of Japanese Plasmablastic Lymphoma Cases. Inter Med. 2010;49:1801-5.
  • 10. Bagul N, Mamatha GS, Mahalle A. Plasmablastic lymphoma of gingiva mimicking a reactive lesion: a case report. Case Rep Dent. 2012;259-307.
  • 11. Mansoor M, Alani FS, Aslam MB, Kumar SN, Sahasrabudhe N, Khan D. A case report of cecal plasmablastic lymphoma in a HIV-negative patient. Eur J Gastroenterol Hepatol. 2012;24(3):332-5.
  • 12. Castillo J, Pantanowitz L, Dezube BJ. HIVassociated plasmablastic lymphoma: lessons learned from 112 published cases. Am J Hematol. 2008;83:804-9.
  • 13. Lorsbach RB, Hsi ED, Dogan A, Fend F. Plasma cell myeloma and related neoplasms. Am J Clin Pathol. 2011;136:168-82.
  • 14. Vega F, Chang CC, Medeiros LJ, et al. Plasmablastic lymphomas and plasmablastic plasma cell myelomas have nearly identical immunophenotypic profiles. Mod Pathol. 2005;18(6):806-15.
  • 15. Sarode SC, Zarkar GA, Desai RS, Sabane VS, Kulkarni MA. Plasmablastic lymphoma of the oral cavity in an HIV-positive patient: a case report and review of literature. Int J Oral Maxillofac Surg. 2009;38(9):993-9.

CD3 Positive Gastric Plasmablastic Lymphoma in a HIV-Negative Patient: A Case Report

Year 2017, , 35 - 38, 31.03.2017
https://doi.org/10.5799/jcei.328751

Abstract

Plasmablastic lymphoma is a rare and aggressive lymphoma characterized by the diffuse proliferation of large
neoplastic cells resembling immunoblasts with an immunophenotype of plasma cells. A 47-year-old male was referred
to our hospital with gastrointestinal bleeding, and a mass 10 cm in diameter, was detected. An endoscopic biopsy was
performed subsequently. Histopathological examination of the biopsy material revealed ulcer, alterations associated
with ulcer, and further presented a diffuse infiltration of atypical cells with abundant cytoplasm and pleomorphic nuclei,
some with crush artifacts in lamina propria. Immunohistochemically, the tumor cells were negative for cytokeratin, CD2,
CD20, and PAX5; but they were positive for CD3, MUM1, CD38 and CD138. Ki67 proliferation index was as high as
95%. The case was signed out as CD3-positive plasmablastic lymphoma with clinical, histopathological and
immunohisto-chemical findings. The plasmablastic lymphoma case with an aberrant CD3 expression has been
presented here, which is rarely observed in stomach.

References

  • 1. Swerdlow SH, Campo E, Harris NL, et al. WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues. Geneva: WHO Press, 2008.
  • 2. Wang HW, Yang W, Sun JZ, Lu JY, Li M, Sun L. Plasmablastic lymphoma of the small intestine: Case report and literature review. World J Gastroenterol. 2012;18(45):6677-81.
  • 3. Hashimoto M, Inaguma S, Kasai K, et al. Plasmablastic lymphoma of the stomach in an HIV-negative patient. Pathol Int. 2012;62(11):763- 70.
  • 4. Rafaniello RP, Pruneri G, Maiorano E. Plasmablastic lymphoma: a review. Oral Dis. 2009;15:38-45.
  • 5. Castillo JJ, Reagan JL. Plasmablastic Lymphoma: A Systematic Review. Sci World J. 2011;11:687- 96.
  • 6. Medeiros, LJ (ed). Diagnostic Pathology: Lymph Nodes and Spleen with Extranodal Lymphomas, 1st edn. Salt Lake City: Amirsys, 2011.
  • 7. Angeleri A, Rocher AE, Myburg C, Avagnina A, Aparo V, Palaoro LA. Plasmablastic lymphoma involving the stomach in an HIV-positive man. Cytopathology. 2016;27(4):293-5.
  • 8. Delecluse HJ, Anagnostopoulos I, Dallenbach F, et al. Plasmablastic lymphomas of the oral cavity: a new entity associated with the human immunodeficiency virus infection. Blood. 1997;89(4):1413-20.
  • 9. Suzuki Y, Yoshida T, Nakamura N, et al. CD3- and CD4-Positive Plasmablastic Lymphoma: A Literature Review of Japanese Plasmablastic Lymphoma Cases. Inter Med. 2010;49:1801-5.
  • 10. Bagul N, Mamatha GS, Mahalle A. Plasmablastic lymphoma of gingiva mimicking a reactive lesion: a case report. Case Rep Dent. 2012;259-307.
  • 11. Mansoor M, Alani FS, Aslam MB, Kumar SN, Sahasrabudhe N, Khan D. A case report of cecal plasmablastic lymphoma in a HIV-negative patient. Eur J Gastroenterol Hepatol. 2012;24(3):332-5.
  • 12. Castillo J, Pantanowitz L, Dezube BJ. HIVassociated plasmablastic lymphoma: lessons learned from 112 published cases. Am J Hematol. 2008;83:804-9.
  • 13. Lorsbach RB, Hsi ED, Dogan A, Fend F. Plasma cell myeloma and related neoplasms. Am J Clin Pathol. 2011;136:168-82.
  • 14. Vega F, Chang CC, Medeiros LJ, et al. Plasmablastic lymphomas and plasmablastic plasma cell myelomas have nearly identical immunophenotypic profiles. Mod Pathol. 2005;18(6):806-15.
  • 15. Sarode SC, Zarkar GA, Desai RS, Sabane VS, Kulkarni MA. Plasmablastic lymphoma of the oral cavity in an HIV-positive patient: a case report and review of literature. Int J Oral Maxillofac Surg. 2009;38(9):993-9.
There are 15 citations in total.

Details

Subjects Health Care Administration
Journal Section Short Report
Authors

Betul Bolat Kucukzeybek

Aylin Orgen Calli

Mehmet Ali Uyaroglu, Et Al. This is me

Publication Date March 31, 2017
Published in Issue Year 2017

Cite

APA Kucukzeybek, B. B., Calli, A. O., & Uyaroglu, Et Al., M. A. (2017). CD3 Positive Gastric Plasmablastic Lymphoma in a HIV-Negative Patient: A Case Report. Journal of Clinical and Experimental Investigations, 8(1), 35-38. https://doi.org/10.5799/jcei.328751
AMA Kucukzeybek BB, Calli AO, Uyaroglu, Et Al. MA. CD3 Positive Gastric Plasmablastic Lymphoma in a HIV-Negative Patient: A Case Report. J Clin Exp Invest. March 2017;8(1):35-38. doi:10.5799/jcei.328751
Chicago Kucukzeybek, Betul Bolat, Aylin Orgen Calli, and Mehmet Ali Uyaroglu, Et Al. “CD3 Positive Gastric Plasmablastic Lymphoma in a HIV-Negative Patient: A Case Report”. Journal of Clinical and Experimental Investigations 8, no. 1 (March 2017): 35-38. https://doi.org/10.5799/jcei.328751.
EndNote Kucukzeybek BB, Calli AO, Uyaroglu, Et Al. MA (March 1, 2017) CD3 Positive Gastric Plasmablastic Lymphoma in a HIV-Negative Patient: A Case Report. Journal of Clinical and Experimental Investigations 8 1 35–38.
IEEE B. B. Kucukzeybek, A. O. Calli, and M. A. Uyaroglu, Et Al., “CD3 Positive Gastric Plasmablastic Lymphoma in a HIV-Negative Patient: A Case Report”, J Clin Exp Invest, vol. 8, no. 1, pp. 35–38, 2017, doi: 10.5799/jcei.328751.
ISNAD Kucukzeybek, Betul Bolat et al. “CD3 Positive Gastric Plasmablastic Lymphoma in a HIV-Negative Patient: A Case Report”. Journal of Clinical and Experimental Investigations 8/1 (March 2017), 35-38. https://doi.org/10.5799/jcei.328751.
JAMA Kucukzeybek BB, Calli AO, Uyaroglu, Et Al. MA. CD3 Positive Gastric Plasmablastic Lymphoma in a HIV-Negative Patient: A Case Report. J Clin Exp Invest. 2017;8:35–38.
MLA Kucukzeybek, Betul Bolat et al. “CD3 Positive Gastric Plasmablastic Lymphoma in a HIV-Negative Patient: A Case Report”. Journal of Clinical and Experimental Investigations, vol. 8, no. 1, 2017, pp. 35-38, doi:10.5799/jcei.328751.
Vancouver Kucukzeybek BB, Calli AO, Uyaroglu, Et Al. MA. CD3 Positive Gastric Plasmablastic Lymphoma in a HIV-Negative Patient: A Case Report. J Clin Exp Invest. 2017;8(1):35-8.