CD3 Positive Gastric Plasmablastic Lymphoma in a HIV-Negative Patient: A Case Report

Year 2017, , 35 - 38, 31.03.2017

Betul Bolat Kucukzeybek , Aylin Orgen Calli , Mehmet Ali Uyaroglu, Et Al.

https://doi.org/10.5799/jcei.328751

Abstract

Plasmablastic lymphoma is a rare and aggressive lymphoma characterized by the diffuse proliferation of large
neoplastic cells resembling immunoblasts with an immunophenotype of plasma cells. A 47-year-old male was referred
to our hospital with gastrointestinal bleeding, and a mass 10 cm in diameter, was detected. An endoscopic biopsy was
performed subsequently. Histopathological examination of the biopsy material revealed ulcer, alterations associated
with ulcer, and further presented a diffuse infiltration of atypical cells with abundant cytoplasm and pleomorphic nuclei,
some with crush artifacts in lamina propria. Immunohistochemically, the tumor cells were negative for cytokeratin, CD2,
CD20, and PAX5; but they were positive for CD3, MUM1, CD38 and CD138. Ki67 proliferation index was as high as
95%. The case was signed out as CD3-positive plasmablastic lymphoma with clinical, histopathological and
immunohisto-chemical findings. The plasmablastic lymphoma case with an aberrant CD3 expression has been
presented here, which is rarely observed in stomach.

Keywords

Plasmablastic lymphoma, CD3, gastric lymphoma

References

• 1. Swerdlow SH, Campo E, Harris NL, et al. WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues. Geneva: WHO Press, 2008.
• 2. Wang HW, Yang W, Sun JZ, Lu JY, Li M, Sun L. Plasmablastic lymphoma of the small intestine: Case report and literature review. World J Gastroenterol. 2012;18(45):6677-81.
• 3. Hashimoto M, Inaguma S, Kasai K, et al. Plasmablastic lymphoma of the stomach in an HIV-negative patient. Pathol Int. 2012;62(11):763- 70.
• 4. Rafaniello RP, Pruneri G, Maiorano E. Plasmablastic lymphoma: a review. Oral Dis. 2009;15:38-45.
• 5. Castillo JJ, Reagan JL. Plasmablastic Lymphoma: A Systematic Review. Sci World J. 2011;11:687- 96.
• 6. Medeiros, LJ (ed). Diagnostic Pathology: Lymph Nodes and Spleen with Extranodal Lymphomas, 1st edn. Salt Lake City: Amirsys, 2011.
• 7. Angeleri A, Rocher AE, Myburg C, Avagnina A, Aparo V, Palaoro LA. Plasmablastic lymphoma involving the stomach in an HIV-positive man. Cytopathology. 2016;27(4):293-5.
• 8. Delecluse HJ, Anagnostopoulos I, Dallenbach F, et al. Plasmablastic lymphomas of the oral cavity: a new entity associated with the human immunodeficiency virus infection. Blood. 1997;89(4):1413-20.
• 9. Suzuki Y, Yoshida T, Nakamura N, et al. CD3- and CD4-Positive Plasmablastic Lymphoma: A Literature Review of Japanese Plasmablastic Lymphoma Cases. Inter Med. 2010;49:1801-5.
• 10. Bagul N, Mamatha GS, Mahalle A. Plasmablastic lymphoma of gingiva mimicking a reactive lesion: a case report. Case Rep Dent. 2012;259-307.
• 11. Mansoor M, Alani FS, Aslam MB, Kumar SN, Sahasrabudhe N, Khan D. A case report of cecal plasmablastic lymphoma in a HIV-negative patient. Eur J Gastroenterol Hepatol. 2012;24(3):332-5.
• 12. Castillo J, Pantanowitz L, Dezube BJ. HIVassociated plasmablastic lymphoma: lessons learned from 112 published cases. Am J Hematol. 2008;83:804-9.
• 13. Lorsbach RB, Hsi ED, Dogan A, Fend F. Plasma cell myeloma and related neoplasms. Am J Clin Pathol. 2011;136:168-82.
• 14. Vega F, Chang CC, Medeiros LJ, et al. Plasmablastic lymphomas and plasmablastic plasma cell myelomas have nearly identical immunophenotypic profiles. Mod Pathol. 2005;18(6):806-15.
• 15. Sarode SC, Zarkar GA, Desai RS, Sabane VS, Kulkarni MA. Plasmablastic lymphoma of the oral cavity in an HIV-positive patient: a case report and review of literature. Int J Oral Maxillofac Surg. 2009;38(9):993-9.