Research Article
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Year 2018, , 9 - 13, 10.03.2018
https://doi.org/10.5799/jcei.413052

Abstract

References

  • 1. Wen Juan H, Wei Wei C, Xia Z. Multiple sclerosis: Pathology, diagnosis and treatments. Exp Therap Med. 2017;13: 3163-6.
  • 2. Yetimalar Y, Seçil Y, Inceoglu AK, et al. Unusual primary manifestations of multiple sclerosis. N Z Med J. 2008;121:47-59.
  • 3. Ergun U, Özer G, Şekercan S, et al. Headaches in the Different Phases of Relapsing-Remitting Multiple Sclerosis A Tedency for Stabbing Headaches During Relapses. Neurologist. 2009l;15):212-6.
  • 4. Elliott DG. Migraine in multiple sclerosis. Int Rev Neurobiol.2007;79:281-302.
  • 5. Kister I, Caminero AB, Monteith TS, et al. Migraine is comorbid with multiple sclerosis and associated with a more symptomatic MS course. J Headache Pain. 2010;11:417-25.
  • 6. Ropper AH, Samuels MA. Multiple sclerosis and allied demyelinating diseases. Adams and Victor’s Principles of Neurology. New York: McGraw-Hill Medical. 2009; 771: 796.
  • 7. Kurtzke JF. Rating neurologic impairment in multiple sclerosis: an expanded disability status scale (EDSS). Neurology. 1988;38 (suppl 1):194.
  • 8.Gee JR, Chang J, Dublin AB, Vijayan N. The association of brainstem lesions with migraine- like headache: an imaging study of multiple sclerosis. Headache. 2005;45:670-7.
  • 9. Haas DC, Kent PF, Friedman DI. Headache caused by a single lesion of multiple sclerosis in the periaqueductal gray area. Headache.1993;33:452-5.
  • 10. Bobholz JA, Rao SM. Cognitive dysfunction in multiple sclerosis: a review of recent developments. Curr Opin Neurol. 2003;16:283-8.
  • 11. D’Amico D, La MAntia L, Rigamonti A, et al. Prevalence of primary headaches in people with multiple sclerosis. Cephalalgia. 2004;24:980-4.
  • 12. Serafin DJ, Weisbrot DM, Ettinger AB. Depression and multiple sclerosis, Depress. Neurol. Disord.: Diagn. Manag. 2012;157–176.
  • 13. Carlos R., et al. The varieties of psychosis in multiple sclerosis: A systematic review of cases. Multiple Sclerosis and Related Disorders. 2017;12: 9-14.
  • 14. Srivastava S, Soma, et al. Headaches in multiple sclerosis: cross-sectional study of a multiethnic population. Clin Neurol Neurosurg. 2016;143:71-5.
  • 15. Sandyk R, Awerbuch GI. The co-occurrence of multiple sclerosis and migraine headache: the serotoninergic link. Int J Neurosci. 1994;76:249-57.
  • 16. Evans RW, Rolak LA. Migraine versus multiple sclerosis. Headache. 2001;41:97-8.
  • 17. Haas DC, Kent PF, Friedman DI. Headache caused by a single lesion of multiple sclerosis in the periaqueductal gray area. Headache.1993;33:452-5.
  • 18. Mansoureh T, et al. Headache in relapse and remission phases of multiple sclerosis: A case-control study. Iranian J Neurol. 2016;15:1-5.
  • 19. Munno I, Marinaro M, Bassi A, et al. Immunological aspects in migraine: increase of IL-10 plasma levels during attack. Headache. 2001;41:764–7.
  • 20. Beebe AM, Cua DJ, de Waal Malefyt R The role of interleukin-10 in autoimmune disease: systemic lupus erythematosus (SLE) and multiple sclerosis (MS). Cytokine Growth Factor Rev. 2002;13:403–12.

Headache in Multiple Sclerosis From a Different Perspective: A Prospective Study

Year 2018, , 9 - 13, 10.03.2018
https://doi.org/10.5799/jcei.413052

Abstract

Objective:
It is known
that patients with multiple sclerosis have a high incidence of headache.
Although there is increasing evidence to suggest that periaqueductal gray
matter (PAG) plays a role in the pathophysiology of migraine headache, it is
not known whether the type of headache may be a predictor of a MS relapse.



Patients
and Methods:
The
study enrolled 100 patients (68 females, 32 males) with clinically confirmed MS
diagnosis established by McDonald diagnostic criteria. The type and duration of
MS, MRI localization of lesions and cognitive status were recorded for all
patients. Patients were questioned whether they experience headache during MS
attacks.



Results:
Sixty-eight
percent of the patients had headache and 32% of the patients were free of
headache. Of the patients with headache, 16% had tension –type headache (TTH),
14% had migraine, 11% had primary stabbing headache (PSH), 8% had TTH+
migraine, 6% had PSH+ migraine, 6% had medication overuse headache , 2% had
medication overuse headache + migraine, 2% had paroxysmal hemicrania, 1% had
cervicogenic headache, 1% had chronic TTH, and 1% had unclassified headache.
There was a statistically significant relationship between the presence of
headache and MS relapse (p<0.001). We found a statistically significant
relationship between the type of headache and the localization of plaques in
all MS patients in a statistical analysis using chi-square test, (p<0.001).



Conclusion:
Headache may be
the only symptom of a flare-up in MS patients. The relationship between
stabbing headache and MS relapses merits further investigation. 

References

  • 1. Wen Juan H, Wei Wei C, Xia Z. Multiple sclerosis: Pathology, diagnosis and treatments. Exp Therap Med. 2017;13: 3163-6.
  • 2. Yetimalar Y, Seçil Y, Inceoglu AK, et al. Unusual primary manifestations of multiple sclerosis. N Z Med J. 2008;121:47-59.
  • 3. Ergun U, Özer G, Şekercan S, et al. Headaches in the Different Phases of Relapsing-Remitting Multiple Sclerosis A Tedency for Stabbing Headaches During Relapses. Neurologist. 2009l;15):212-6.
  • 4. Elliott DG. Migraine in multiple sclerosis. Int Rev Neurobiol.2007;79:281-302.
  • 5. Kister I, Caminero AB, Monteith TS, et al. Migraine is comorbid with multiple sclerosis and associated with a more symptomatic MS course. J Headache Pain. 2010;11:417-25.
  • 6. Ropper AH, Samuels MA. Multiple sclerosis and allied demyelinating diseases. Adams and Victor’s Principles of Neurology. New York: McGraw-Hill Medical. 2009; 771: 796.
  • 7. Kurtzke JF. Rating neurologic impairment in multiple sclerosis: an expanded disability status scale (EDSS). Neurology. 1988;38 (suppl 1):194.
  • 8.Gee JR, Chang J, Dublin AB, Vijayan N. The association of brainstem lesions with migraine- like headache: an imaging study of multiple sclerosis. Headache. 2005;45:670-7.
  • 9. Haas DC, Kent PF, Friedman DI. Headache caused by a single lesion of multiple sclerosis in the periaqueductal gray area. Headache.1993;33:452-5.
  • 10. Bobholz JA, Rao SM. Cognitive dysfunction in multiple sclerosis: a review of recent developments. Curr Opin Neurol. 2003;16:283-8.
  • 11. D’Amico D, La MAntia L, Rigamonti A, et al. Prevalence of primary headaches in people with multiple sclerosis. Cephalalgia. 2004;24:980-4.
  • 12. Serafin DJ, Weisbrot DM, Ettinger AB. Depression and multiple sclerosis, Depress. Neurol. Disord.: Diagn. Manag. 2012;157–176.
  • 13. Carlos R., et al. The varieties of psychosis in multiple sclerosis: A systematic review of cases. Multiple Sclerosis and Related Disorders. 2017;12: 9-14.
  • 14. Srivastava S, Soma, et al. Headaches in multiple sclerosis: cross-sectional study of a multiethnic population. Clin Neurol Neurosurg. 2016;143:71-5.
  • 15. Sandyk R, Awerbuch GI. The co-occurrence of multiple sclerosis and migraine headache: the serotoninergic link. Int J Neurosci. 1994;76:249-57.
  • 16. Evans RW, Rolak LA. Migraine versus multiple sclerosis. Headache. 2001;41:97-8.
  • 17. Haas DC, Kent PF, Friedman DI. Headache caused by a single lesion of multiple sclerosis in the periaqueductal gray area. Headache.1993;33:452-5.
  • 18. Mansoureh T, et al. Headache in relapse and remission phases of multiple sclerosis: A case-control study. Iranian J Neurol. 2016;15:1-5.
  • 19. Munno I, Marinaro M, Bassi A, et al. Immunological aspects in migraine: increase of IL-10 plasma levels during attack. Headache. 2001;41:764–7.
  • 20. Beebe AM, Cua DJ, de Waal Malefyt R The role of interleukin-10 in autoimmune disease: systemic lupus erythematosus (SLE) and multiple sclerosis (MS). Cytokine Growth Factor Rev. 2002;13:403–12.
There are 20 citations in total.

Details

Primary Language English
Subjects Health Care Administration
Journal Section Research Article
Authors

Gökhan Özer

Ufuk Ergün

Levent Ertuğrul İnan

Publication Date March 10, 2018
Published in Issue Year 2018

Cite

APA Özer, G., Ergün, U., & İnan, L. E. (2018). Headache in Multiple Sclerosis From a Different Perspective: A Prospective Study. Journal of Clinical and Experimental Investigations, 9(1), 9-13. https://doi.org/10.5799/jcei.413052
AMA Özer G, Ergün U, İnan LE. Headache in Multiple Sclerosis From a Different Perspective: A Prospective Study. J Clin Exp Invest. March 2018;9(1):9-13. doi:10.5799/jcei.413052
Chicago Özer, Gökhan, Ufuk Ergün, and Levent Ertuğrul İnan. “Headache in Multiple Sclerosis From a Different Perspective: A Prospective Study”. Journal of Clinical and Experimental Investigations 9, no. 1 (March 2018): 9-13. https://doi.org/10.5799/jcei.413052.
EndNote Özer G, Ergün U, İnan LE (March 1, 2018) Headache in Multiple Sclerosis From a Different Perspective: A Prospective Study. Journal of Clinical and Experimental Investigations 9 1 9–13.
IEEE G. Özer, U. Ergün, and L. E. İnan, “Headache in Multiple Sclerosis From a Different Perspective: A Prospective Study”, J Clin Exp Invest, vol. 9, no. 1, pp. 9–13, 2018, doi: 10.5799/jcei.413052.
ISNAD Özer, Gökhan et al. “Headache in Multiple Sclerosis From a Different Perspective: A Prospective Study”. Journal of Clinical and Experimental Investigations 9/1 (March 2018), 9-13. https://doi.org/10.5799/jcei.413052.
JAMA Özer G, Ergün U, İnan LE. Headache in Multiple Sclerosis From a Different Perspective: A Prospective Study. J Clin Exp Invest. 2018;9:9–13.
MLA Özer, Gökhan et al. “Headache in Multiple Sclerosis From a Different Perspective: A Prospective Study”. Journal of Clinical and Experimental Investigations, vol. 9, no. 1, 2018, pp. 9-13, doi:10.5799/jcei.413052.
Vancouver Özer G, Ergün U, İnan LE. Headache in Multiple Sclerosis From a Different Perspective: A Prospective Study. J Clin Exp Invest. 2018;9(1):9-13.