Research Article
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Year 2018, , 40 - 44, 10.03.2018
https://doi.org/10.5799/jcei.413072

Abstract

References

  • 1. Lateef TM, Cui L, Nelson KB, Nakamura EF, Merikangas KR. Physical Comorbidity of Migraine and Other Headaches in US Adolescents. J Pediatr. 2012;161:308–13.
  • 2. Smitherman TA, Burch R, Sheikh H, Loder E. The prevalence, impact, and treatment of migraine and severe headaches in the United States: a review of statistics from national surveillance studies. Headache 2013;53:427–36.
  • 3. Yoon MS, Katsarava Z, Obermann M, et al. Prevalence of primary headaches in Germany: Results of the German Headache Consortium Study. J Headache Pain. 2012;13:215–23.
  • 4. Battista J, Badcock DR, McKendrick AM. Migraine increases centre-surround suppression for drifting visual stimuli. PLOS One. 2011;6:e18211.
  • 5. Schürks M, Rist PM, Bigal ME, Buring JE, Lipton RB, Kurth T. Migraine and cardiovascular disease: Systematic review and meta-analysis. BMJ. 2009;339:b3914.
  • 6. Ertas M, Baykan B, Orhan EK, et al. One-year prevalence and the impact of migraine and tension-type headache in Turkey: A nationwide home-based study in adults. J Headache Pain. 2012;13:147–57.
  • 7. Buell JS, Dawson-Hughes B. Vitamin D and neurocognitive dysfunction: preventing “D“ecline? Mol. Aspects Med. 2008;29:415–22.
  • 8. Prabhakar P, Majumdar V, Kulkarni GB, Christopher R. Genetic variants of vitamin D receptor and susceptibility to ischemic stroke. Biochem. Biophys. Res. Commun. 2015;456:631–6.
  • 9. Prakash S, Mehta NC, Dabhi AS, Lakhani O, Khilari M, Shah ND. The prevalence of headache may be related with the latitude: A possible role of Vitamin D insufficiency? J Headache Pain. 2010;11:301–7.
  • 10. Andıran N, Çelik N, Akça H, Doğan G. Vitamin D deficiency in children and adolescents. J Clin Res Pediatr Endocrinol. 2012;4:25–9. 11. Motaghi M, et al. Relationship between vitamin D receptor gene polymorphisms and migraine without aura in an Iranian population. Biomed Res Int. 2013;351942.
  • 12. Zandifar A. et al. Vitamin D status in migraine patients: a case-control study. Biomed Res Int. 2014;514782.
  • 13. Asadi B, Khorvash F, Najaran A, Khorvash F. Cyproheptadine versus propranolol in the prevention of migraine headaches in children. Pak J Med Sci. 2012;28:309–11.
  • 14. Kjaergaard M, Eggen AE, Mathiesen EB, Jorde R. Association between headache and serum 25-hydroxyvitamin D; the Tromso Study: Tromso 6. Headache 2012; 52: 1499-505.
  • 15. Virtanen JK, Giniatullin R ,et al. Low serum 25-hydroxyvitamin D is associated with higher risk of frequent headache in middle-aged and older men. Sci Rep. 2017;7: 39697.
  • 16. Mottaghi T, Khorvash F, Askari G, Maracy MR, Maghsoudi RGZ. The relationship between serum levels of vitamin D and migraine. J Res Med Sci. 2013; 18): S66–S70.
  • 17. Kjćrgaard M, Eggen AE, Mathiesen EB, Jorde R. Association Between Headache and Serum 25-Hydroxyvitamin D; the Tromsø Study: Tromsø 6. Headache. 2012;52:1499–505.
  • 18. Thys-Jacobs S. Vitamin D and calcium in menstrual migraine. Headache. 1994;34:544–6.
  • 19. Thys-Jacobs S. Alleviation of migraines with therapeutic vitamin D and calcium. Headache. 1994;34:590–2.
  • 20. Prakash S, Shah ND. Chronic tension-type headache with vitamin D deficiency: Casual or causal association? Headache. 2009;49:1214–22.

The impact of serum 25-hydroxyvitamin D level on migraine headache

Year 2018, , 40 - 44, 10.03.2018
https://doi.org/10.5799/jcei.413072

Abstract

Objective:
To investigate
the impact of serum 25-hydroxyvitamin D levels on migraine headache in
migraineurs



Patients
and Methods:
A
total of 72 patients were included in the study. Serum vitamin D concentration
and its impact on the migraine headache were assessed in migraineurs and
migraine subgroups. To assess serum levels of vitamin D, 25(OH) D3 was measured
by enzyme-linked immunosorbent assay (ELISA). Patients were categorized as
follows based on the results of serum vitamin D measurements. Severity of
migraine, average duration and frequency of attacks per month were recorded.
The headache diary result (HDR) was determined as: Duration of headache ×
frequency of headache.



Results:
Average vitamin
D level was 7.4 ng/ml among patients with migraine with aura group and 8.5
ng/ml in patients with migraine without aura. Severe vitamin D deficiency was
detected in 14 (66.7%) patients with migraine with aura and 9 (64.3%) patients
with migraine without aura, with no statistically significant difference
between the two groups. No significant correlation was found between vitamin D
levels and HDR among migraineurs (r=-0.042, p=0.812) as well as in patients
with migraine with aura (r=0.044, p=0.842) and in patients with migraine
without aura (r=0.059, p=0.842) versus control group with respect to HDR and
vitamin D levels. The severity of migraine pain was not associated with vitamin
D levels. Serum vitamin D concentration was lower in male patients versus control
group.



Conclusion:
The impact of
vitamin D on the severity and number of migraine attacks is not clear. Further
studies are needed to demonstrate the association between vitamin D status and
neurological diseases.




References

  • 1. Lateef TM, Cui L, Nelson KB, Nakamura EF, Merikangas KR. Physical Comorbidity of Migraine and Other Headaches in US Adolescents. J Pediatr. 2012;161:308–13.
  • 2. Smitherman TA, Burch R, Sheikh H, Loder E. The prevalence, impact, and treatment of migraine and severe headaches in the United States: a review of statistics from national surveillance studies. Headache 2013;53:427–36.
  • 3. Yoon MS, Katsarava Z, Obermann M, et al. Prevalence of primary headaches in Germany: Results of the German Headache Consortium Study. J Headache Pain. 2012;13:215–23.
  • 4. Battista J, Badcock DR, McKendrick AM. Migraine increases centre-surround suppression for drifting visual stimuli. PLOS One. 2011;6:e18211.
  • 5. Schürks M, Rist PM, Bigal ME, Buring JE, Lipton RB, Kurth T. Migraine and cardiovascular disease: Systematic review and meta-analysis. BMJ. 2009;339:b3914.
  • 6. Ertas M, Baykan B, Orhan EK, et al. One-year prevalence and the impact of migraine and tension-type headache in Turkey: A nationwide home-based study in adults. J Headache Pain. 2012;13:147–57.
  • 7. Buell JS, Dawson-Hughes B. Vitamin D and neurocognitive dysfunction: preventing “D“ecline? Mol. Aspects Med. 2008;29:415–22.
  • 8. Prabhakar P, Majumdar V, Kulkarni GB, Christopher R. Genetic variants of vitamin D receptor and susceptibility to ischemic stroke. Biochem. Biophys. Res. Commun. 2015;456:631–6.
  • 9. Prakash S, Mehta NC, Dabhi AS, Lakhani O, Khilari M, Shah ND. The prevalence of headache may be related with the latitude: A possible role of Vitamin D insufficiency? J Headache Pain. 2010;11:301–7.
  • 10. Andıran N, Çelik N, Akça H, Doğan G. Vitamin D deficiency in children and adolescents. J Clin Res Pediatr Endocrinol. 2012;4:25–9. 11. Motaghi M, et al. Relationship between vitamin D receptor gene polymorphisms and migraine without aura in an Iranian population. Biomed Res Int. 2013;351942.
  • 12. Zandifar A. et al. Vitamin D status in migraine patients: a case-control study. Biomed Res Int. 2014;514782.
  • 13. Asadi B, Khorvash F, Najaran A, Khorvash F. Cyproheptadine versus propranolol in the prevention of migraine headaches in children. Pak J Med Sci. 2012;28:309–11.
  • 14. Kjaergaard M, Eggen AE, Mathiesen EB, Jorde R. Association between headache and serum 25-hydroxyvitamin D; the Tromso Study: Tromso 6. Headache 2012; 52: 1499-505.
  • 15. Virtanen JK, Giniatullin R ,et al. Low serum 25-hydroxyvitamin D is associated with higher risk of frequent headache in middle-aged and older men. Sci Rep. 2017;7: 39697.
  • 16. Mottaghi T, Khorvash F, Askari G, Maracy MR, Maghsoudi RGZ. The relationship between serum levels of vitamin D and migraine. J Res Med Sci. 2013; 18): S66–S70.
  • 17. Kjćrgaard M, Eggen AE, Mathiesen EB, Jorde R. Association Between Headache and Serum 25-Hydroxyvitamin D; the Tromsø Study: Tromsø 6. Headache. 2012;52:1499–505.
  • 18. Thys-Jacobs S. Vitamin D and calcium in menstrual migraine. Headache. 1994;34:544–6.
  • 19. Thys-Jacobs S. Alleviation of migraines with therapeutic vitamin D and calcium. Headache. 1994;34:590–2.
  • 20. Prakash S, Shah ND. Chronic tension-type headache with vitamin D deficiency: Casual or causal association? Headache. 2009;49:1214–22.
There are 19 citations in total.

Details

Primary Language English
Subjects Health Care Administration
Journal Section Research Article
Authors

Gökhan Özer

Publication Date March 10, 2018
Published in Issue Year 2018

Cite

APA Özer, G. (2018). The impact of serum 25-hydroxyvitamin D level on migraine headache. Journal of Clinical and Experimental Investigations, 9(1), 40-44. https://doi.org/10.5799/jcei.413072
AMA Özer G. The impact of serum 25-hydroxyvitamin D level on migraine headache. J Clin Exp Invest. March 2018;9(1):40-44. doi:10.5799/jcei.413072
Chicago Özer, Gökhan. “The Impact of Serum 25-Hydroxyvitamin D Level on Migraine Headache”. Journal of Clinical and Experimental Investigations 9, no. 1 (March 2018): 40-44. https://doi.org/10.5799/jcei.413072.
EndNote Özer G (March 1, 2018) The impact of serum 25-hydroxyvitamin D level on migraine headache. Journal of Clinical and Experimental Investigations 9 1 40–44.
IEEE G. Özer, “The impact of serum 25-hydroxyvitamin D level on migraine headache”, J Clin Exp Invest, vol. 9, no. 1, pp. 40–44, 2018, doi: 10.5799/jcei.413072.
ISNAD Özer, Gökhan. “The Impact of Serum 25-Hydroxyvitamin D Level on Migraine Headache”. Journal of Clinical and Experimental Investigations 9/1 (March 2018), 40-44. https://doi.org/10.5799/jcei.413072.
JAMA Özer G. The impact of serum 25-hydroxyvitamin D level on migraine headache. J Clin Exp Invest. 2018;9:40–44.
MLA Özer, Gökhan. “The Impact of Serum 25-Hydroxyvitamin D Level on Migraine Headache”. Journal of Clinical and Experimental Investigations, vol. 9, no. 1, 2018, pp. 40-44, doi:10.5799/jcei.413072.
Vancouver Özer G. The impact of serum 25-hydroxyvitamin D level on migraine headache. J Clin Exp Invest. 2018;9(1):40-4.