The impact of serum 25-hydroxyvitamin D level on migraine headache

Year 2018, , 40 - 44, 10.03.2018

Gökhan Özer

https://doi.org/10.5799/jcei.413072

Abstract

Objective:
To investigate
the impact of serum 25-hydroxyvitamin D levels on migraine headache in
migraineurs

Patients
and Methods: A
total of 72 patients were included in the study. Serum vitamin D concentration
and its impact on the migraine headache were assessed in migraineurs and
migraine subgroups. To assess serum levels of vitamin D, 25(OH) D3 was measured
by enzyme-linked immunosorbent assay (ELISA). Patients were categorized as
follows based on the results of serum vitamin D measurements. Severity of
migraine, average duration and frequency of attacks per month were recorded.
The headache diary result (HDR) was determined as: Duration of headache ×
frequency of headache.

Results:
Average vitamin
D level was 7.4 ng/ml among patients with migraine with aura group and 8.5
ng/ml in patients with migraine without aura. Severe vitamin D deficiency was
detected in 14 (66.7%) patients with migraine with aura and 9 (64.3%) patients
with migraine without aura, with no statistically significant difference
between the two groups. No significant correlation was found between vitamin D
levels and HDR among migraineurs (r=-0.042, p=0.812) as well as in patients
with migraine with aura (r=0.044, p=0.842) and in patients with migraine
without aura (r=0.059, p=0.842) versus control group with respect to HDR and
vitamin D levels. The severity of migraine pain was not associated with vitamin
D levels. Serum vitamin D concentration was lower in male patients versus control
group.

Conclusion:
The impact of
vitamin D on the severity and number of migraine attacks is not clear. Further
studies are needed to demonstrate the association between vitamin D status and
neurological diseases.

Keywords

Migraine, 25-hydroxyvitamin D, headache

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