Research Article
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Year 2018, , 87 - 90, 13.06.2018
https://doi.org/10.5799/jcei.433812

Abstract

References

  • 1. Engel J, Pedley TA, Aicardy, J, and Dichter MA. Epilepsy: A Comprehensive Textbook, 2nd Ed. Philadelphia; Lippincott, Williams & Wilkins 2007.
  • 2. Pearson-Smith JN, Patel M. Metabolic Dysfunction and Oxidative Stress in Epilepsy. Int J Mol Sci. 2017;8:18-21.
  • 3. Zaidi Z. Body asymmetries: Incidence, etiology and clinical implication. Australian J Basic Applied Sci 2011;5:2157–91.
  • 4. Good CD, Johnsrude I, Ashburner J, Henson RNA, Friston KJ, Frackowiak RSJ. Cerebral asymmetry and the effects of sex and handedness on brain structure: A voxel-based morphometric analysis of 465 normal adult human brains. NeuroImage. 2001;14.
  • 5. Fink B, Manning JT, Neave N. The 2nd–4th digit ratio (2D:4D) and neck circumference: Implications for risk factors in coronary heart disease, Int J Obesity. 2006;30:711–4.
  • 6. Stolten M, Ledet E, Dotiwala A, Luk E, Sartor O. Alternative digit ratios and their relationship to prostate cancer, Clin Genitourin Cancer. 2016;14:149–52.
  • 7. Kasielska-Trojan A, Antoszewski B. Can digit ratio (2D:4D) studies be helpful in explaining the aetiology of idiopathic gynecomastia? Early Human Development 2015;91:57–61.
  • 8. Manning JT, Baron-Cohen S, Wheelwright S, Sanders G. The 2nd to 4th digit ratio and autism. Develop Medicine & Child Neurol. 2001;43:160– 4.
  • 9. Manning JT. Digit Ratio: A Pointer to Fertility, Behavior, and Health. Rutgers Univ. Press, New Brunswick NJ 2002.
  • 10. Bejerot S, Erikson JM, Bonde S, Carlström K, Humble MB, Eriksson E. The extreme male brain revisited: Sex coherence in adults with autism spectrum disorder. Brit J Psychiatry. 2012;16;118–123.
  • 11. Robinson SJ, Manning JT. The ratio of 2nd to 4th digit length and male homosexuality. Evolution Human Behavior. 2000;21:333–45.
  • 12. Triversa R, Manningb J, Jacobsona A. A longitudinal study of digit ratio (2D:4D) and other finger ratios in Jamaican children. Hormones Behavior. 2006;49:150–6.
  • 13. Ertugrul B, Otag I. Relationship between sexually dimorphic body morphology and second-to-fourth digit ratio. Insan Bilim Derg.i 2012;1:94–107.
  • 14. Hudson JM, Hodgson JC. Is digit ratio (2D:4D) a reliable pointer to speech laterality? Behavioral Brain Res. 2016;301:258–61.
  • 15. David AP, Steven JCG, Robert JS, Donald HM. Sex hormones and finger length. What does 2D:4D indicate? Evolution Human Behavior. 2004;25:182–99.
  • 16. Lutchmaya S, Baron-Cohen S, Raggatt P, Knickmeyer R, Manning JT. 2nd to 4th digit ratios, fetal testosterone and estradiol. Early Hum Dev. 2004;77:23–8.
  • 17. Malas MA, Dogan S, Evcil EH, Desdicioglu K. Fetal development of the hand, digits and digit ratio (2D:4D), 2006, Early Human Development. 2006;82:469–75.
  • 18. Putz DA, Gaulin SJC, Sporter RJ, McBurney DH. Sex hormones and finger length What does 2D:4D indicate? Evolution Human Behavior. 2004;25:182-199.
  • 19. Manning JT, Scutt D, Wilson J, Lewis-Jones DI. The ratio of 2nd to 4th digit length: A predictor of sperm numbers and concentrations of testosterone, luteinizing hormone and oestrogen., Hum Reprod. 1998;13:3000–4.
  • 20. Geschwind N, Behan P. Left-handedness: Association with immune disease, migraine, and developmental learning disorder, National Acad Sci. 1982;79: 5097–5100.
  • 21. El-Khayat HA, Shatla HM, Ali GK, Abdulgani MO, Tomoum HY and Attya HA. Physical and hormonal profile of male sexual development in epilepsy. Epilepsia. 2003;44:447–52.
  • 22. Scharfman HE, Kim M, Hintz TM and MacLusky NJ. Seizures and reproductive function, insights from female rats with epilepsy. Ann Neurol. 2008;64:687–97.
  • 23. Bauer J, Stoffel-Wagner B, Flügel D, Kluge M, Schramm J, Bidlingmaier F, et al. Serum androgens return to normal after temporal lobe epilepsy surgery in men. Neurology 2000;55:820–4.
  • 24. Logothetis J, Harner R and Morrel F. Theroleofestrogens in catamenial exacerbation of epilepsy. Neurology. 1959;9:352–60.
  • 25. Reibel S, André V, Chassagnon S, André G, Marescaux C, Nehlig A, et al. Neuroprotective effects of chronic estradiol benzoate treatment on hippocampal cell loss induced by status epilepticus in the female rat. Neurosci Lett. 2000;281:79–82.
  • 26. Garn SM, Burdi AR, Babler WJ, Stinson S. Early prenatal attainment of adult metacarpal-phalangeal rankings and proportions, Am J Phys Anthropol. 1975;43:327–32.
  • 27. Fink B, Manning JT and Neave N. The 2nd–4th digit ratio (2D:4D) and neck circumference: Implications for risk factors in coronary heart disease. Int J Obesity. 2006;30:711–714.

Evaluation of relationship between digit ratio (2D: 4D) and epilepsy: Can 2D:4D be a clue for epileptogenesis?

Year 2018, , 87 - 90, 13.06.2018
https://doi.org/10.5799/jcei.433812

Abstract

Objective: The aim of the study was to investigate the possible association between the 2D:4D
ratio and epilepsy in male and female adults, and to compare the ratios of epilepsy patients and
healthy control subjects.
Patients and Methods: A case-control study carried out at a neurology and biophyiscs
department in Ankara Yıldırım Beyazıt University, Faculty of Medicine from May 2016 to January
2017. The 2D:4D ratios of both the left and right hands of 172 epilepsy patients and 202
matched healthy controls were recorded. All participants also completed the Edinburgh
handedness inventory.
Results: A significant positive correlation between the 2D:4D ratio and epilepsy was found for
both females and males; a lower ratio for the left hand was associated with a higher possibility
of epilepsy. In addition, a lower ratio in a specific hand was associated with that hand being
used to complete the handedness test.
Conclusions: The 2D:4D ratio serves as a predictor for increased risk of epilepsy. Thus, it could
be used as a marker to differentiate patients with epilepsy from healthy controls.

References

  • 1. Engel J, Pedley TA, Aicardy, J, and Dichter MA. Epilepsy: A Comprehensive Textbook, 2nd Ed. Philadelphia; Lippincott, Williams & Wilkins 2007.
  • 2. Pearson-Smith JN, Patel M. Metabolic Dysfunction and Oxidative Stress in Epilepsy. Int J Mol Sci. 2017;8:18-21.
  • 3. Zaidi Z. Body asymmetries: Incidence, etiology and clinical implication. Australian J Basic Applied Sci 2011;5:2157–91.
  • 4. Good CD, Johnsrude I, Ashburner J, Henson RNA, Friston KJ, Frackowiak RSJ. Cerebral asymmetry and the effects of sex and handedness on brain structure: A voxel-based morphometric analysis of 465 normal adult human brains. NeuroImage. 2001;14.
  • 5. Fink B, Manning JT, Neave N. The 2nd–4th digit ratio (2D:4D) and neck circumference: Implications for risk factors in coronary heart disease, Int J Obesity. 2006;30:711–4.
  • 6. Stolten M, Ledet E, Dotiwala A, Luk E, Sartor O. Alternative digit ratios and their relationship to prostate cancer, Clin Genitourin Cancer. 2016;14:149–52.
  • 7. Kasielska-Trojan A, Antoszewski B. Can digit ratio (2D:4D) studies be helpful in explaining the aetiology of idiopathic gynecomastia? Early Human Development 2015;91:57–61.
  • 8. Manning JT, Baron-Cohen S, Wheelwright S, Sanders G. The 2nd to 4th digit ratio and autism. Develop Medicine & Child Neurol. 2001;43:160– 4.
  • 9. Manning JT. Digit Ratio: A Pointer to Fertility, Behavior, and Health. Rutgers Univ. Press, New Brunswick NJ 2002.
  • 10. Bejerot S, Erikson JM, Bonde S, Carlström K, Humble MB, Eriksson E. The extreme male brain revisited: Sex coherence in adults with autism spectrum disorder. Brit J Psychiatry. 2012;16;118–123.
  • 11. Robinson SJ, Manning JT. The ratio of 2nd to 4th digit length and male homosexuality. Evolution Human Behavior. 2000;21:333–45.
  • 12. Triversa R, Manningb J, Jacobsona A. A longitudinal study of digit ratio (2D:4D) and other finger ratios in Jamaican children. Hormones Behavior. 2006;49:150–6.
  • 13. Ertugrul B, Otag I. Relationship between sexually dimorphic body morphology and second-to-fourth digit ratio. Insan Bilim Derg.i 2012;1:94–107.
  • 14. Hudson JM, Hodgson JC. Is digit ratio (2D:4D) a reliable pointer to speech laterality? Behavioral Brain Res. 2016;301:258–61.
  • 15. David AP, Steven JCG, Robert JS, Donald HM. Sex hormones and finger length. What does 2D:4D indicate? Evolution Human Behavior. 2004;25:182–99.
  • 16. Lutchmaya S, Baron-Cohen S, Raggatt P, Knickmeyer R, Manning JT. 2nd to 4th digit ratios, fetal testosterone and estradiol. Early Hum Dev. 2004;77:23–8.
  • 17. Malas MA, Dogan S, Evcil EH, Desdicioglu K. Fetal development of the hand, digits and digit ratio (2D:4D), 2006, Early Human Development. 2006;82:469–75.
  • 18. Putz DA, Gaulin SJC, Sporter RJ, McBurney DH. Sex hormones and finger length What does 2D:4D indicate? Evolution Human Behavior. 2004;25:182-199.
  • 19. Manning JT, Scutt D, Wilson J, Lewis-Jones DI. The ratio of 2nd to 4th digit length: A predictor of sperm numbers and concentrations of testosterone, luteinizing hormone and oestrogen., Hum Reprod. 1998;13:3000–4.
  • 20. Geschwind N, Behan P. Left-handedness: Association with immune disease, migraine, and developmental learning disorder, National Acad Sci. 1982;79: 5097–5100.
  • 21. El-Khayat HA, Shatla HM, Ali GK, Abdulgani MO, Tomoum HY and Attya HA. Physical and hormonal profile of male sexual development in epilepsy. Epilepsia. 2003;44:447–52.
  • 22. Scharfman HE, Kim M, Hintz TM and MacLusky NJ. Seizures and reproductive function, insights from female rats with epilepsy. Ann Neurol. 2008;64:687–97.
  • 23. Bauer J, Stoffel-Wagner B, Flügel D, Kluge M, Schramm J, Bidlingmaier F, et al. Serum androgens return to normal after temporal lobe epilepsy surgery in men. Neurology 2000;55:820–4.
  • 24. Logothetis J, Harner R and Morrel F. Theroleofestrogens in catamenial exacerbation of epilepsy. Neurology. 1959;9:352–60.
  • 25. Reibel S, André V, Chassagnon S, André G, Marescaux C, Nehlig A, et al. Neuroprotective effects of chronic estradiol benzoate treatment on hippocampal cell loss induced by status epilepticus in the female rat. Neurosci Lett. 2000;281:79–82.
  • 26. Garn SM, Burdi AR, Babler WJ, Stinson S. Early prenatal attainment of adult metacarpal-phalangeal rankings and proportions, Am J Phys Anthropol. 1975;43:327–32.
  • 27. Fink B, Manning JT and Neave N. The 2nd–4th digit ratio (2D:4D) and neck circumference: Implications for risk factors in coronary heart disease. Int J Obesity. 2006;30:711–714.
There are 27 citations in total.

Details

Primary Language English
Subjects Health Care Administration
Journal Section Research Article
Authors

Gülsüm Akdeniz This is me

Publication Date June 13, 2018
Published in Issue Year 2018

Cite

APA Akdeniz, G. (2018). Evaluation of relationship between digit ratio (2D: 4D) and epilepsy: Can 2D:4D be a clue for epileptogenesis?. Journal of Clinical and Experimental Investigations, 9(2), 87-90. https://doi.org/10.5799/jcei.433812
AMA Akdeniz G. Evaluation of relationship between digit ratio (2D: 4D) and epilepsy: Can 2D:4D be a clue for epileptogenesis?. J Clin Exp Invest. June 2018;9(2):87-90. doi:10.5799/jcei.433812
Chicago Akdeniz, Gülsüm. “Evaluation of Relationship Between Digit Ratio (2D: 4D) and Epilepsy: Can 2D:4D Be a Clue for Epileptogenesis?”. Journal of Clinical and Experimental Investigations 9, no. 2 (June 2018): 87-90. https://doi.org/10.5799/jcei.433812.
EndNote Akdeniz G (June 1, 2018) Evaluation of relationship between digit ratio (2D: 4D) and epilepsy: Can 2D:4D be a clue for epileptogenesis?. Journal of Clinical and Experimental Investigations 9 2 87–90.
IEEE G. Akdeniz, “Evaluation of relationship between digit ratio (2D: 4D) and epilepsy: Can 2D:4D be a clue for epileptogenesis?”, J Clin Exp Invest, vol. 9, no. 2, pp. 87–90, 2018, doi: 10.5799/jcei.433812.
ISNAD Akdeniz, Gülsüm. “Evaluation of Relationship Between Digit Ratio (2D: 4D) and Epilepsy: Can 2D:4D Be a Clue for Epileptogenesis?”. Journal of Clinical and Experimental Investigations 9/2 (June 2018), 87-90. https://doi.org/10.5799/jcei.433812.
JAMA Akdeniz G. Evaluation of relationship between digit ratio (2D: 4D) and epilepsy: Can 2D:4D be a clue for epileptogenesis?. J Clin Exp Invest. 2018;9:87–90.
MLA Akdeniz, Gülsüm. “Evaluation of Relationship Between Digit Ratio (2D: 4D) and Epilepsy: Can 2D:4D Be a Clue for Epileptogenesis?”. Journal of Clinical and Experimental Investigations, vol. 9, no. 2, 2018, pp. 87-90, doi:10.5799/jcei.433812.
Vancouver Akdeniz G. Evaluation of relationship between digit ratio (2D: 4D) and epilepsy: Can 2D:4D be a clue for epileptogenesis?. J Clin Exp Invest. 2018;9(2):87-90.