Evaluation of TNFRSF11B Gene Polymorphism in Patients with Acute Stroke

Year 2016, Volume: 7 Issue: 2, 184 - 189, 16.06.2016

Pınar Çoğaş

https://doi.org/10.5799/ahinjs.01.2016.02.0594

Abstract

Objective: Tumor necrosis factor receptor superfamily,
member 11b (TNFRSF11B) has been suggested to be a risk fac­tor for
atherosclerosis and cardiovascular diseases because of the observation
of osteoporosis and vascular diseases together in human, and the high
levels of serum TNFRSF11B in these patients in clinical trials. In this
study, we aimed to investigate the association between TNFRSF11B gene
1181G˃C polymorphism and acute stroke as a cerebrovascular disease.

Methods: In this study, the DNAs of 107 acute stroke
patients and 100 healthy controls have been analyzed by poly­merase
chain reaction (PCR) and restriction fragment length polymorphism
(RFLP). Statistical analyses were performed by using chi-square and
analysis of variance tests.

Results: When we compared the genotype and allele
frequencies of patients and controls, any statistically significant
differences was not found between them (p=0.476 and p=0.622,
respectively). Any association also was not observed when demographical
and clinical characteristics of patients was compared with TNFRSF11B
gene 1181G˃C polymor­phism (p>0.05).

Conclusion: As a result, our findings showed that
there was no association between TNFRSF11B gene 1181G>C poly­morphism
and acute stroke. However, further studies can reveal more clearly
whether there is a relationship between TNFRSF11B gene polymorphism and
acute stroke in Turkish population.

Keywords

TNFRSF11B, acute stroke, polymorphism

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