The Relationship of Vitamin B12 Deficiency and Red Cell Distribution Width-Platelet Ratio

Year 2016, Volume: 7 Issue: 3, 211 - 213, 01.09.2016

Nigar Yılmaz Mustafa Yılmaz

https://doi.org/10.5799/jcei.328604

Abstract

Objective: We aimed to investigate the relationship between vitamin B12 deficiency and red cell distribution widthplatelet
ratio (RPR), and the variations in the parameters on vitamin B12 treatment.
Methods: One hundred fifty-four patients with untreated vitamin B12 deficiency (56% men, mean age: 50 ± 12.7 years)
(untreated group), 86 patients with vitamin B12 deficiency (62% men, mean age: 42 ± 20.7 years) on vitamin B12 treatment
(treated group), and 92 age- and sex-matched control group (54% men, mean age: 45 ± 15.1 years) were included
in the study. Hematological parameters were evaluated by the method of laser-based flow cytometric impedance, using
an automated blood cell counter (ABX Pentra 120 Hematology Blood Analyzer).
Results: RPR was significantly reduced in treated group compared with untreated group (4.88 ± 1.06; 6.13 ± 1.27;
p<0.001, respectively). RPR, red cell distribution width (RDW) and mean platelet volume (MPV) were significantly different
in untreated group compared to controls (p<0.05). There were no differences in platelet count in the three groups
(p>0.05).
Conclusion: We proposed that vitamin B12 deficiency has effects on RPR and supplementation with vitamin B12 corrects
the RPR levels. J Clin Exp Invest 2016; 7 (3): 211-215

Keywords

Vitamin B12 deficiency, red cell distribution width-platelet ratio, vitamin B12 treatment, Mean platelet volume

References

• 1. Eussen SJ, Ueland PM, Hiddink GJ, et al. Changes in markers of cobalamin status after cessation of oral B-vitamin supplements in elderly people with mild cobalamin deficiency. Eur J Clin Nutr. 2008;62:1248-51.
• 2. Stabler SP. Clinical practice. Vitamin B12 deficiency. N Engl J Med. 2013;368:149-60.
• 3. Sucharita S, Thomas T, Sowmya S, Krishnamachari S, Kurpad AV, Vaz M. Subclinical vitamin B12 deficiency and heart rate variability across life cycle. Curr Aging Sci. 2016 Feb 11. [Epub ahead of print]
• 4. Lachner C, Steinle NI, Regenold WT. The neuropsychiatry of vitamin B12 deficiency in elderly patients. J Neuropsychiatry Clin Neurosci. 2012;24:5-15.
• 5. McCully KS. The active site of oxidative phosphorylation and the origin of hyperhomocysteinemia in aging and dementia. Ann Clin Lab Sci. 2015;45:222-5.
• 6. McCully KS. Homocysteine Metabolism, Atherosclerosis, and Diseases of Aging. Compr Physiol. 2015;6:471-505.
• 7. Köbe T, Witte AV, Schnelle A, et al. Vitamin B-12 concentration, memory performance, and hippocampal structure in patients with mild cognitive impairment. Am J Clin Nutr. 2016 Feb 24. pii: ajcn116970. [Epub ahead of print]
• 8. Tajarernmuang P, Phrommintikul A, Limsukon A, et al. The Role of Mean Platelet Volume as a Predictor of Mortality in Critically Ill Patients: A Systematic Review and MetaAnalysis. Crit Care Res Pract. 2016;2016:4370834.
• 9. Sansanayudh N, Anothaisintawee T, Muntham D, et al. Mean platelet volume and coronary artery disease: a systematic review and meta-analysis. Int J Cardiol. 2014;175:433-40.
• 10. Celık T, Balta S, Demır M, et al. Predictive value of admission red cell distribution width-platelet ratio for no-reflow phenomenon in acute ST segment elevation myocardial infarction undergoing primary percutaneous coronary intervention. Cardiol J. 2016;23:84-92.
• 11. Mézière A, Audureau E, Vairelles S, et al. B12 deficiency increases with age in hospitalized patients: a study on 14,904 samples. J Gerontol A Biol Sci Med Sci. 2014;69:1576-85.
• 12. C.W. Chan, S.Y. Liu, C.S. Kho, et al. Diagnostic clues to megaloblastic anaemia without macrocytosis. Int J Lab Hematol 2007;29:163-171.
• 13. J. Oh, S.M. Kang, N. Hong, et al. Relation between red cell distribution width with echocardiographic parameters in patients with acute heart failure. J Card Fail, 2009;15:517- 22.
• 14. Yang W, Huang H, Wang Y, et al. High red blood cell distribution width is closely associated with nonalcoholic fatty liver disease. Eur J Gastroenterol Hepatol. 2014;26:174-8.
• 15. Patel KV, Semba RD, Ferrucci L, et al. Red cell distribution width and mortality in older adults: a meta-analysis. J Gerontol A Biol Sci Med Sci. 2010;65:258-65.
• 16. Sansanayudh N, Numthavaj P, Muntham D, et al. Prognostic effect of mean platelet volume in patients with coronary artery disease. A systematic review and meta-analysis. Thromb Haemost. 2015;114:1299-309.
• 17. Mohan IV, Jagroop IA, Mikhailidis DP, Stansby GP. Homocysteine activates platelets in vitro. Clin Appl ThrombHem. 2008;14:8-18.
• 18. McCully KS. Homocysteine and the pathogenesis of atherosclerosis. Expert Rev Clin Pharmacol. 2015;8:211-9.
• 19. Kelkitli E, Ozturk N, Aslan NA, et al. Serum zinc levels in patients with iron deficiency anemia and its association with symptoms of iron deficiency anemia. Ann Hematol. 2016. [Epub ahead of print]
• 20. Dugdale AE. Predicting iron and folate deficiency anaemias from standard blood testing: the mechanism and implications for clinical medicine and public health in developing countries. Theor Biol Med Model. 2006;3:34.
• 21. Demir R, Saritemur M, Ozel L, et al. Red cell distribution width identifies cerebral venous sinus thrombosis in patients with headache. Clin Appl Thromb Hemost. 2015;21:354-8.
• 22. Yin P, Lv H, Zhang L, et al. Combination of red cell distribution width and American Society of Anesthesiologists score for hip fracture mortality prediction. Osteoporos Int. 2016. [Epub ahead of print]
• 23. Bhatia P, Kulkarni JD, Pai SA. Vitamin B12 deficiency in India: Mean corpuscular volume is an unreliable screening parameter. National Medical Joural of India. 2012;25:336-8.
• 24. Uçar M, Vatansever F, Tanık N, et al. The comparison of mean platelet volume and other hemogram results in patients with carpal tunnel syndrome. J Clin Exp Invest 2015;6:154-8.
• 25. Vizioli L, Muscari S, Muscari A. The relationship of mean platelet volume with the risk and prognosis of cardiovascular diseases. Int J Clin Pract. 2009;63:1509-15.
• 26. Doğan K, Guraslan H, Senturk MB, et al. Can Platelet Count and Platelet Indices Predict the Risk and the Prognosis of Preeclampsia? Hypertens Pregnancy. 2015;34:434-42.
• 27. Haungsaithong R, Udommongkol C, Nidhinandana S, et al. The Changes in Mean Platelet Volume after Using of Antiplatelet Drugs in Acute Ischemic Stroke: A Randomized Controlled Trial. J Med Assoc Thai. 2015;98:852-7.
• 28. Tekeoğlu İ, Gürol G, Harman H, et al. Overlooked hematological markers of disease activity in rheumatoid arthritis. Int J Rheum Dis. 2015. doi: 10.1111/1756-185X.12805. [Epub ahead of print]
• 29. Aktas G, Alcelik A, Tekce BK, et al. Red cell distribution width and mean platelet volume in patients with irritable bowel syndrome. Prz Gastroenterol. 2014;9:160-3.
• 30. Elbey B, Yazgan ÜC, Yıldırım A, et al. Mean platelet volume and neutrophil to lymphocyte ratio in patients with vernal keratoconjunctivitis. J Clin Exp Invest. 2015;6:40-3.