Analyzing the Effect of c-myc Oncogene and Matrix Mettalloproteinase-2 Enzyme Ekspression on Metastasis and Prognosis of Malignant Melanoma

Year 2016, Volume: 7 Issue: 3, 222 - 228, 01.09.2016

Abdulcebbar Siyer Yasemin Yuyucu Karabulut , Şakir Ünal Didem Derici

https://doi.org/10.5799/jcei.328612

Abstract

Objectives: The aim of this study is to measure the effect of c-myc oncogene and matrix metalloproteinase-2 enzyme
expression on metastasis and prognosis of malignant melanoma. At the end of this study, we hope to get information
about the prognosis of melanoma, to be helpful for choosing the treatment strategy.
Methods: Sixty-three patients treated in our hospital during 2006-2015 were included in this study. All clinical and
histological parameters were collected from each patient’s records and survival rate is assessed. Forty-seven suitable
tumor specimens were assessed by immunohistochemical stains and analyzed for the c-myc and MMP-2 positivity. All
results were evaluated statistically for the effect on melanoma metastasis and survival rate.
Results: C-myc positivity and MMP-2 positivity decreases the survival rate of melanoma. MMP-2 positivity increases
the risk of death four more times.
Conclusions: So this study confirms that we can evaluate c-myc and MMP-2 as a prognostic factor. 

Keywords

Malignant , melanoma , C-myc , Matrix metalloproteinase 2 , oncogene , metastasis

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