Evaluation of Follow-up Results in Children with Henoch-Schönlein Purpura

Year 2016, Volume: 7 Issue: 4, 269 - 277, 01.12.2016

Dursun Eryılmaz Aydın Ece

https://doi.org/10.5799/jcei.328558

Abstract

Objective: The aim of this study was to investigate long-term follow-up results of children Henoch-Schönlein purpura
(HSP).
Methods: 102 children (66 boys and 36 girls) with HSP followed up at Pediatric Department of Dicle University
Faculty of Medicine between 1996 and 2002 were included. Demographic, clinical and laboratory characteristics of
children, treatment modalities and complications were reviewed from the follow-up charts of patients. Fourty-eigth
children who came to control after a period of 40.8±19.9 months underwent a thorough clinical and laboratory work
up. Clinical and laboratory findings accompanying specific organ involvements were investigated.
Results: In total, 91.2% had purpuric eruption, 62.7% had gastrointestinal system (GIS) involvement, 28.4% had
renal involvement and 43.1% had arthritis. Triggering factors were upper respiratory tract infection in 55%,
vaccination in 2 and drugs in 2 patients. Gastrointestinal involvement was significantly more frequent in children with
high immunglobulin A levels (p=0.012), renal involvement was significantly more frequent in children with high
erythrocyte sedimentation rate (p=0.006). GIS involvement was more frequent in patients over 7 years (p<0.05).
Significant correlations were found between renal involvement and leukocytosis, thrombocytosis and high C-reactive
(41.2%) with skin eruptions and in 33 (32.4%) with abdominal discomfort. Symptoms and signs were relapsed two
times in 12 patients and three times in 13. The existence of hypertension, older age, low C3 levels were found to be
associated with renal involvement in logistic regression analysis (p<0.05).
Conclusion: Increased IgA level and age over 7 were associated with GIS involvement, while high acute phase
reactants and older age were found to be related with renal involvement. J Clin Exp Invest 2016; 7(4): 269-277. 

Keywords

Henoch-Schönlein Purpura, children, clinical findings, laboratory findings, follow up results

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