Case Report
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Year 2018, Volume: 9 Issue: 2, 100 - 102, 13.06.2018

Erdinç Şengüldür

https://doi.org/10.5799/jcei.433821

Abstract

References

  • 1. Evoy KE, Morrison MD, Saklad SR. Abuse and misuse of pregabalin and gabapentin. Drugs. 2017; 77: 403-26.
  • 2. Milicevic C, Crnobaric C, Nikolic S, Lecic-Tosevski D. A case of pregabalin intoxication. Psychiatriki. 2012;23:162-5.
  • 3. Ben-Menachem E. Pregabalin pharmacology and its relevance to clinical practice. Epilepsia. 2004;45:13-18.
  • 4. Aksakal E, Bakırcı E, Emet M. Complete atrioventricular block due to overdose of pregabalin. Am J Emerg Med. 2012;30:2101.
  • 5. Randinitis EJ, Posvar EL, Alvey CW, Sedman AJ, Cook JA, Bockbrader HN. Pharmacokinetics of pregabalin in subjects with various degrees of renal function. J Clin Pharmacol. 2003;43:277-83.
  • 6. De Smedt RHE, Jaarsma T, van den Broek SAJ, Haaijer-Ruskamp FM. Decompensation of chronic heart failure associatedwith pregabalin in a 73-year-old patient withpostherpetic neuralgia: a case report. Br J Clin Pharmacol. 2008;66:327-8. 7. De Smedt RHE, Jaarsma T, van den Broek SAJ, Haaijer-Ruskamp FM. Decompensation of chronic heart failure associatedwith pregabalin in a 73-year-old patient withpostherpetic neuralgia: a case report. Br J Clin Pharmacol. 2008;66:327-8.
  • 8. Belli E, Erkalp K, Yangın Z, Fadıllıoğlu S, Alagöl A. A new analgesic drug: pregabalin and the first intoxications. Agri. 2013; 25: 187-9.

Pregabalin Intoxication-Induced Prolonged PR Interval on Electrocardiogram

Year 2018, Volume: 9 Issue: 2, 100 - 102, 13.06.2018

Erdinç Şengüldür

https://doi.org/10.5799/jcei.433821

Abstract

Pregabalin is a lipophilic analogue of gamma-aminobutyric acid (GABA) and has a similar
chemical structure to gabapentin and is more potent than gabapentin. This report documents
the case of a 28-year-old male presenting with suicidal attempt by pregabalin intake. The
patient had an abnormal PR interval (reversible AV-block). He was managed with general
supportive care and symptomatic approach such as discontinuation of the drug, hydration with
IV fluids, oxygenation, gastric lavage and activated charcoal administration.

Keywords

Pregabalin intoxication AV-block

References

  • 1. Evoy KE, Morrison MD, Saklad SR. Abuse and misuse of pregabalin and gabapentin. Drugs. 2017; 77: 403-26.
  • 2. Milicevic C, Crnobaric C, Nikolic S, Lecic-Tosevski D. A case of pregabalin intoxication. Psychiatriki. 2012;23:162-5.
  • 3. Ben-Menachem E. Pregabalin pharmacology and its relevance to clinical practice. Epilepsia. 2004;45:13-18.
  • 4. Aksakal E, Bakırcı E, Emet M. Complete atrioventricular block due to overdose of pregabalin. Am J Emerg Med. 2012;30:2101.
  • 5. Randinitis EJ, Posvar EL, Alvey CW, Sedman AJ, Cook JA, Bockbrader HN. Pharmacokinetics of pregabalin in subjects with various degrees of renal function. J Clin Pharmacol. 2003;43:277-83.
  • 6. De Smedt RHE, Jaarsma T, van den Broek SAJ, Haaijer-Ruskamp FM. Decompensation of chronic heart failure associatedwith pregabalin in a 73-year-old patient withpostherpetic neuralgia: a case report. Br J Clin Pharmacol. 2008;66:327-8. 7. De Smedt RHE, Jaarsma T, van den Broek SAJ, Haaijer-Ruskamp FM. Decompensation of chronic heart failure associatedwith pregabalin in a 73-year-old patient withpostherpetic neuralgia: a case report. Br J Clin Pharmacol. 2008;66:327-8.
  • 8. Belli E, Erkalp K, Yangın Z, Fadıllıoğlu S, Alagöl A. A new analgesic drug: pregabalin and the first intoxications. Agri. 2013; 25: 187-9.
There are 7 citations in total.

Details

Primary Language English
Subjects Health Care Administration
Journal Section Case Report
Authors

Erdinç Şengüldür This is me

Publication Date June 13, 2018
Published in Issue Year 2018 Volume: 9 Issue: 2

Cite

APA Şengüldür, E. (2018). Pregabalin Intoxication-Induced Prolonged PR Interval on Electrocardiogram. Journal of Clinical and Experimental Investigations, 9(2), 100-102. https://doi.org/10.5799/jcei.433821
AMA Şengüldür E. Pregabalin Intoxication-Induced Prolonged PR Interval on Electrocardiogram. J Clin Exp Invest. June 2018;9(2):100-102. doi:10.5799/jcei.433821
Chicago Şengüldür, Erdinç. “Pregabalin Intoxication-Induced Prolonged PR Interval on Electrocardiogram”. Journal of Clinical and Experimental Investigations 9, no. 2 (June 2018): 100-102. https://doi.org/10.5799/jcei.433821.
EndNote Şengüldür E (June 1, 2018) Pregabalin Intoxication-Induced Prolonged PR Interval on Electrocardiogram. Journal of Clinical and Experimental Investigations 9 2 100–102.
IEEE E. Şengüldür, “Pregabalin Intoxication-Induced Prolonged PR Interval on Electrocardiogram”, J Clin Exp Invest, vol. 9, no. 2, pp. 100–102, 2018, doi: 10.5799/jcei.433821.
ISNAD Şengüldür, Erdinç. “Pregabalin Intoxication-Induced Prolonged PR Interval on Electrocardiogram”. Journal of Clinical and Experimental Investigations 9/2 (June 2018), 100-102. https://doi.org/10.5799/jcei.433821.
JAMA Şengüldür E. Pregabalin Intoxication-Induced Prolonged PR Interval on Electrocardiogram. J Clin Exp Invest. 2018;9:100–102.
MLA Şengüldür, Erdinç. “Pregabalin Intoxication-Induced Prolonged PR Interval on Electrocardiogram”. Journal of Clinical and Experimental Investigations, vol. 9, no. 2, 2018, pp. 100-2, doi:10.5799/jcei.433821.
Vancouver Şengüldür E. Pregabalin Intoxication-Induced Prolonged PR Interval on Electrocardiogram. J Clin Exp Invest. 2018;9(2):100-2.