BibTex RIS Cite

The largest reference range study for hematological parameters from Turkey: A case control study

Year 2014, Volume: 5 Issue: 4, 548 - 552, 01.12.2014
https://doi.org/10.5799/ahinjs.01.2014.04.0455

Abstract

Objectives: Accurate, reliable laboratory reference ranges are essential for effective clinical evaluation and monitoring. We present robust reference ranges established for hematology parameters using the Sysmex XT2000i analyzer. Methods: Blood samples were taken from 17409 healthy adults (19 to 49 years, 51.4% men and 48.6% women) and routine hematology analysis performed. Patients were assessed as healthy on the basis of a medical history and routine medical examinations. Serum hematinic assays (vitamin B12, folate, iron and ferritin) were also analyzed in order to exclude the potential anemia existence. Results: There was a statistically significant difference (p

References

  • Bain BJ. Normal range in blood cells. A Practical Guide, Blackwell Scientific Publications, 3rd edn. Oxford, UK, 2002:857-894.
  • Lewis SM, Bain BJ, and Bates I. Reference ranges and normal values. Practical Haematology, 3rd edn Churchill Levingstone, New York, NY, USA, 2006:11- 24.
  • Giorno R, Clifford JH, Beverly S, Rossing RG. Hema- tology reference values. Analysis by different statisti- cal technics and variations with age and sex. Am J Clin Pathol 1980;74:765–770.
  • Saxena S, Wong ET. Heterogeneity of common hema- tologic parameters among racial, ethnic, and gender subgroups. Arch Pathol Lab Med 1990;114:715-719.
  • Bain B, Seed M, Godsland I. Normal values for periph- eral blood white cell counts in women of four different ethnic origins. J Clin Pathol 1984;37:188–193.
  • Terzioglu M, Savcı D, Ozek A, et al. Türklerde normal hematolojik değerler. Ist Univ Tıp Fak J 1953;16:193- 207.
  • Basak M, Gul S, Kucukardali Y, et al. Türkiye’de he- mogram değerleri ile ilgili randomize referans değer çalışması. Turkey. Turk J Haematol Oncol 1998;8:69- 72.
  • Kaya H, Kiki I, Akarsu E, et al. Hematological values of healthy adult population living at moderate alti- tude (1869 m, Erzurum, Turkey). Turk J Haematol 2000;17:123-128.
  • National Committee for Clinical Laboratory Standards. How to Define and Determine Reference Intervals in the Clinical Laboratory; approved guideline – 2nd edn. bC28-A2, 2000;20:13.
  • National Committee for Clinical Laboratory Stan- dards. Procedures for collection of diagnostic blood specimens by venopuncture; approved guideline H3- A3. Wayne, PA, NCCLS, 1991.
  • National Committee for Clinical Laboratory Standards. Procedures for the handling and processing of blood specimens; approved guideline H18-A. Wayne, PA: NCCLS, 1990.
  • Solberg H. Approved recommendation on the theory of reference values. Part 5. Statistical treatment of col- lected reference values. Determination of reference limits. J Clin Chem Clin Biochem 1987;25:645–656.
  • Gilmour JW, Stevens WS, Gray C, Souza M. Labo- ratory expansion to large-scale international HIV preventive vaccine trials. Current Opinion in HIV and AIDS 2008;2:201–206.
  • Kocak R, Alparslan ZN, Agridag G, Baslamisli F, Ak- sungur PD, Koltas S. The frequency of anaemia, iron deficiency, hemoglobin S and beta thalassemia in the south of Turkey. Eur J Epid 1995;11:181-184.
  • Pfaeffli J. Reference limits for the automated haema- tology analyser Sysmex XE-2100. Sysmex Journal International 2002;1:20-28.
  • Perkins S. Normal blood and bone marrow values in humans. In: Lee G, Foerster J, Lukens J, et al. editors. Wintrobe’s clinical hematology, 10th edn. Baltimore: Williams & Wilkins, 1998:2738.
  • Kratz A, Lewandrowski K. MGH Case records: nor- mal reference laboratory values. N Engl J Med 1998;339:1063–1072.
  • Wakeman L, Al-Ismail S, et al. Robust, routine hae- matology reference ranges for healthy Adults. Int Jnl Lab Hem 2007:1-5.
  • Kaya Z. Interpretation of automated blood cell counts. Dicle Med J 2013;40:521-528.
  • Kueviakoe IM, Segbena A, Jouault H, Vovor A, Imbert M. Hematological reference values for healthy adults in Togo. ISRN Hematology 2011:1-5.
  • Nordin G, Martensson A, Swolin B, et al. A multicen- tre study of reference intervals for haemoglobin, basic blood cell counts and erythrocyte indices in the adult population of the Nordic countries. Scand J Clin Lab Invest 2004;64:385–398.
  • Bain BJ, England JM. Normal haematological val- ues: sex difference in the neutrophil count. BMJ7 1975;11:473-475.
  • Bain BJ. Platelet count and platelet size in men and women. Scand J Haematol 1985;35:77-79.
  • Milman N, Byg K, Mulvad G, Pederson HS, Bjer- regaard P. Haemoglobin concentrations appear lower in indigenous Greenlanders than in Danes: assess- ment of haemoglobin in 234 Greenlanders and 2804 Danes. Eur J Haemat 2001;67:23-29.
  • Houwen B. The blood cell count. In: Advanced meth- ods in haematology. (eds. R.M. Rowan, O.W. van As- sendelft & F.E. Preston), Arnold, London, 2002:37.

The largest reference range study for hematological parameters from Turkey: A case control study

Year 2014, Volume: 5 Issue: 4, 548 - 552, 01.12.2014
https://doi.org/10.5799/ahinjs.01.2014.04.0455

Abstract

Amaç: Doğru, güvenilir laboratuvar referans aralıkları etkili klinik değerlendirme ve izleme için gereklidir. Biz hematoloji parametreleri için belirlenmiş mevcut referans aralıklarını Sysmex XT2000i analizörü kullanarak sunuyoruz. Yöntemler: kan örnekleri 17409 sağlıklı erişkinden (yaş aralığı, 19 ile 49 yıl arasında, %51,4 erkek ve %48,6 kadın) alındı ve rutin hematoloji analizi yapıldı. Hastalar, tıbbi geçmişleri ve rutin muayenelerine dayanarak sağlıklı olarak değerlendirildi. Serum hematinik testleri (vitamin B12, folat, demir ve ferritin) de çalışılarak potansiyel anemi varlığı hariç tutuldu. Bulgular: Kadın ve erkek arasında belirgin istatistiksel farklılık (p

References

  • Bain BJ. Normal range in blood cells. A Practical Guide, Blackwell Scientific Publications, 3rd edn. Oxford, UK, 2002:857-894.
  • Lewis SM, Bain BJ, and Bates I. Reference ranges and normal values. Practical Haematology, 3rd edn Churchill Levingstone, New York, NY, USA, 2006:11- 24.
  • Giorno R, Clifford JH, Beverly S, Rossing RG. Hema- tology reference values. Analysis by different statisti- cal technics and variations with age and sex. Am J Clin Pathol 1980;74:765–770.
  • Saxena S, Wong ET. Heterogeneity of common hema- tologic parameters among racial, ethnic, and gender subgroups. Arch Pathol Lab Med 1990;114:715-719.
  • Bain B, Seed M, Godsland I. Normal values for periph- eral blood white cell counts in women of four different ethnic origins. J Clin Pathol 1984;37:188–193.
  • Terzioglu M, Savcı D, Ozek A, et al. Türklerde normal hematolojik değerler. Ist Univ Tıp Fak J 1953;16:193- 207.
  • Basak M, Gul S, Kucukardali Y, et al. Türkiye’de he- mogram değerleri ile ilgili randomize referans değer çalışması. Turkey. Turk J Haematol Oncol 1998;8:69- 72.
  • Kaya H, Kiki I, Akarsu E, et al. Hematological values of healthy adult population living at moderate alti- tude (1869 m, Erzurum, Turkey). Turk J Haematol 2000;17:123-128.
  • National Committee for Clinical Laboratory Standards. How to Define and Determine Reference Intervals in the Clinical Laboratory; approved guideline – 2nd edn. bC28-A2, 2000;20:13.
  • National Committee for Clinical Laboratory Stan- dards. Procedures for collection of diagnostic blood specimens by venopuncture; approved guideline H3- A3. Wayne, PA, NCCLS, 1991.
  • National Committee for Clinical Laboratory Standards. Procedures for the handling and processing of blood specimens; approved guideline H18-A. Wayne, PA: NCCLS, 1990.
  • Solberg H. Approved recommendation on the theory of reference values. Part 5. Statistical treatment of col- lected reference values. Determination of reference limits. J Clin Chem Clin Biochem 1987;25:645–656.
  • Gilmour JW, Stevens WS, Gray C, Souza M. Labo- ratory expansion to large-scale international HIV preventive vaccine trials. Current Opinion in HIV and AIDS 2008;2:201–206.
  • Kocak R, Alparslan ZN, Agridag G, Baslamisli F, Ak- sungur PD, Koltas S. The frequency of anaemia, iron deficiency, hemoglobin S and beta thalassemia in the south of Turkey. Eur J Epid 1995;11:181-184.
  • Pfaeffli J. Reference limits for the automated haema- tology analyser Sysmex XE-2100. Sysmex Journal International 2002;1:20-28.
  • Perkins S. Normal blood and bone marrow values in humans. In: Lee G, Foerster J, Lukens J, et al. editors. Wintrobe’s clinical hematology, 10th edn. Baltimore: Williams & Wilkins, 1998:2738.
  • Kratz A, Lewandrowski K. MGH Case records: nor- mal reference laboratory values. N Engl J Med 1998;339:1063–1072.
  • Wakeman L, Al-Ismail S, et al. Robust, routine hae- matology reference ranges for healthy Adults. Int Jnl Lab Hem 2007:1-5.
  • Kaya Z. Interpretation of automated blood cell counts. Dicle Med J 2013;40:521-528.
  • Kueviakoe IM, Segbena A, Jouault H, Vovor A, Imbert M. Hematological reference values for healthy adults in Togo. ISRN Hematology 2011:1-5.
  • Nordin G, Martensson A, Swolin B, et al. A multicen- tre study of reference intervals for haemoglobin, basic blood cell counts and erythrocyte indices in the adult population of the Nordic countries. Scand J Clin Lab Invest 2004;64:385–398.
  • Bain BJ, England JM. Normal haematological val- ues: sex difference in the neutrophil count. BMJ7 1975;11:473-475.
  • Bain BJ. Platelet count and platelet size in men and women. Scand J Haematol 1985;35:77-79.
  • Milman N, Byg K, Mulvad G, Pederson HS, Bjer- regaard P. Haemoglobin concentrations appear lower in indigenous Greenlanders than in Danes: assess- ment of haemoglobin in 234 Greenlanders and 2804 Danes. Eur J Haemat 2001;67:23-29.
  • Houwen B. The blood cell count. In: Advanced meth- ods in haematology. (eds. R.M. Rowan, O.W. van As- sendelft & F.E. Preston), Arnold, London, 2002:37.
There are 25 citations in total.

Details

Primary Language Turkish
Journal Section Research Article
Authors

Nilgun Tekkeşin This is me

Huseyin Bekoz This is me

Faruk Tukenmez This is me

Publication Date December 1, 2014
Published in Issue Year 2014 Volume: 5 Issue: 4

Cite

APA Tekkeşin, N., Bekoz, H., & Tukenmez, F. (2014). The largest reference range study for hematological parameters from Turkey: A case control study. Journal of Clinical and Experimental Investigations, 5(4), 548-552. https://doi.org/10.5799/ahinjs.01.2014.04.0455
AMA Tekkeşin N, Bekoz H, Tukenmez F. The largest reference range study for hematological parameters from Turkey: A case control study. J Clin Exp Invest. December 2014;5(4):548-552. doi:10.5799/ahinjs.01.2014.04.0455
Chicago Tekkeşin, Nilgun, Huseyin Bekoz, and Faruk Tukenmez. “The Largest Reference Range Study for Hematological Parameters from Turkey: A Case Control Study”. Journal of Clinical and Experimental Investigations 5, no. 4 (December 2014): 548-52. https://doi.org/10.5799/ahinjs.01.2014.04.0455.
EndNote Tekkeşin N, Bekoz H, Tukenmez F (December 1, 2014) The largest reference range study for hematological parameters from Turkey: A case control study. Journal of Clinical and Experimental Investigations 5 4 548–552.
IEEE N. Tekkeşin, H. Bekoz, and F. Tukenmez, “The largest reference range study for hematological parameters from Turkey: A case control study”, J Clin Exp Invest, vol. 5, no. 4, pp. 548–552, 2014, doi: 10.5799/ahinjs.01.2014.04.0455.
ISNAD Tekkeşin, Nilgun et al. “The Largest Reference Range Study for Hematological Parameters from Turkey: A Case Control Study”. Journal of Clinical and Experimental Investigations 5/4 (December 2014), 548-552. https://doi.org/10.5799/ahinjs.01.2014.04.0455.
JAMA Tekkeşin N, Bekoz H, Tukenmez F. The largest reference range study for hematological parameters from Turkey: A case control study. J Clin Exp Invest. 2014;5:548–552.
MLA Tekkeşin, Nilgun et al. “The Largest Reference Range Study for Hematological Parameters from Turkey: A Case Control Study”. Journal of Clinical and Experimental Investigations, vol. 5, no. 4, 2014, pp. 548-52, doi:10.5799/ahinjs.01.2014.04.0455.
Vancouver Tekkeşin N, Bekoz H, Tukenmez F. The largest reference range study for hematological parameters from Turkey: A case control study. J Clin Exp Invest. 2014;5(4):548-52.