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Demographic characteristics and ocular involvement in Behçet patients in Southeast Anatolia

Year 2013, Volume: 4 Issue: 3, 339 - 342, 01.09.2013
https://doi.org/10.5799/ahinjs.01.2013.03.0297

Abstract

Objective: The aim of this study was to evaluate the demographic characteristics of Behcet's disease (BD) patients with and without ocular involvement. Methods: In this retrospective study BD patients followed up between 2009 and 2013 years in ophthalmology and dermatology clinics were reviewed. Patients were divided into 2 groups according to the ocular involvement as ocular or non-ocular BD. For each patient, age of onset, gender, family history, and systemic involvement were examined. The frequency of these data was analyzed. Results: Of the 295 patients 177 were ocular BD and 118 were non-ocular BD. Ocular involvement were seen more frequently in male patients than in females. There was no change between the groups in terms of age at onset of the disease, a history of thrombophlebitis or gastrointestinal, pulmonary and joint involvement. Pathergy test positivity and the presence of genital ulcers had more frequent in non-ocular BD. Conclusion: In this study clinical and demographic characteristics of ocular and non-ocular BD patients in the Southeast Anatolian Region of Turkey were presented. A similar study was not performed previously in our region therefore we believe that those data will be useful for diagnosis and follow-up of BD patients. J Clin Exp Invest 2013; 4 (3): 339-342

References

  • Behcet H. Uber rezidivivierende Aphthose, durch ein Virus verursachte Geschwure am Mund, am Auge und an den Genitalien. Dermatol Wochenschr 1937;105:1152-1157.
  • Yazici H, Fresko I, Yurdakul S. Behçet’s syndrome: disease manifestations, management, and advances in treatment. Nat Clin Pract Rheumatol 2007;3:148-155.
  • Sakane T, Takeno M, Suzuki N, Inaba G. Behçet’s disease. N Engl J Med 1999;341:1284-1291.
  • Mishima S, Masuda K, Izawa Y, et al. The eighth Freder- ick H. Verhoeff Lecture. presented by Saiichi Mishima, MD Behçet’s disease in Japan: ophthalmologic aspects. Trans Am Ophthalmol Soc 1979;77:225-279.
  • Saylan T, Mat C, Fresko I, Melikoğlu M. Behçet’s disease in the Middle East. Clin Dermatol 1999;17:209-223.
  • Nussenblatt RB, Whitcup SM, Palestine AG (1996) Be- hçet’s disease. In: Nussenblatt RB, Whitcup SM, Pales- tine AG (eds) Uveitis: fundamentals and clinical practice. Mosby, St Louis, pp 334-353.
  • Colvard DM, Robertson DM, O’Duffy JD. The ocular manifestations of Behçet’s disease. Arch Ophthalmol 1977;95:1813-1817.
  • International Study Group for Behçet’s Disease Evalu- ation of diagnostic (‘classification’) criteria in Behçet’s disease: toward internationally agreed criteria. Lancet 1990;335:1078-1080.
  • Verity DH, Marr JE, Ohno S, et al. Behçet’s disease, the Silk Road and HLA-B51: historical and geographical per- spectives. Tissue Antigens 1999;54:213-220.
  • Cingu AK, Onal S, Urgancioglu M, Tugal-Tutkun I. Com- parison of presenting features and three-year disease course in Turkish patients with Behçet uveitis who pre- sented in the early 1990s and the early 2000s. Ocul Im- munol Inflamm 2012;20:423-428.
  • Gürler A, İdil A, Boyvat A, Çalışkan D. AÜTF İbni Sina hastanesi Behçet Merkezine 1976-1997 yılları arasında başvuran 2175 olgunun cinse göre ilk semptom başlama yaşının değerlendirilmesi. Türkiye Klin Dermatoloji Derg 2000;10:83.
  • Tugal-Tutkun I, Onal S, Altan-Yaycioglu R, et al. Uveitis in Behçet disease: an analysis of 880 patients. Am J Oph- thalmol 2004;138:373-380.
  • Uslu M, Karaman G, Şavk E, ve ark. Aydında Behçet has- talığı deneyimi: 67 hastanın retrospektif değerlendirilmesi. ADÜ Tıp Fak Dergisi 2008;9:21-26.
  • Soylu M, Şekeroğlu HT, Erdem E, Demircan N. Behcet’s disease: The clinical and demographic characteristics of 406 patients. Turk J Rheumatol 2012;27:115-120.
  • Dogan B, Taskapan O, Harmanyeri Y. Prevalance of pathergy test positivity in Behçet’s disease in Turkey. J Eur Acad Dermatol Venereol 2003;17:228-229.
  • Tursen U, Gurler A, Boyvat A. Evaluation of clinical find- ings according to sex in 2313 Turkish patients with Be- hçet’s disease. Int J Dermatol 2003;42:346-351.
  • Gürler A, Boyvat A, Türsen U. Clinical manifestations of Behçet’s disease: an analysis of 2147 patients. Yonsei Med J 1997;38:423-427.
  • Sungur GK, Hazirolan D, Yalvac I, et al. Clinical and de- mographic evaluation of Behçet disease among different paediatric age groups. Br J Ophthalmol 2009;93:83-87.
  • Karincaoglu Y, Borlu M, Toker SC, et al. Demographic and clinical properties of juvenile-onset Behçet’s dis- ease: A controlled multicenter study. J Am Acad Dermatol 2008;58:579-584.
  • Sungur G, Hazirolan D, Hekimoglu E, et al. Late-onset Be- hçet’s disease: demographic, clinical, and ocular features. Graefes Arch Clin Exp Ophthalmol 2010;248:1325-1330.

Güneydoğu Anadolu bölgesindeki Behçet hastalarında oküler tutulum ve demografik özellikler

Year 2013, Volume: 4 Issue: 3, 339 - 342, 01.09.2013
https://doi.org/10.5799/ahinjs.01.2013.03.0297

Abstract

Amaç: Kliniğimizde takip edilen oküler tutulumu olan ve olmayan Behçet hastalarının demografik özelliklerini irdelemektir. Yöntemler: Bu retrospektif çalışmada 2009-2013 yılları arasında Behçet hastalığı nedeni ile göz ve dermatoloji kliniklerinde takip edilen olguların verileri tarandı. Hastalar oküler tutulumu olanlar ve olmayanlar olarak 2 gruba ayrıldı. Her bir olgu için başlangıç yaşı, cinsiyet, aile öyküsü ve sistemik tutulum özellikleri incelendi. Verilerin sıklıkları değerlendirildi. Bulgular: Dosya kayıt bilgileri değerlendirilen toplam 295 olgunun 177\'inde oküler tutulum mevcut iken 118\'nde oküler tutulum yoktu. Erkek olgularda oküler tutulum daha fazla izlendi. Gruplar arasında hastalığın başlangıç yaşı, tromboflebit öyküsü, gastrointestinal, pulmoner ve eklem tutulumu açısından farklılık izlenmedi. Paterji testi pozitifliği ve genital ülser varlığı oküler tutulum olmayan olgularda daha fazla izlendi. Sonuç: Yaptığımız çalışma ile Güneydoğu Anadolu Bölgesindeki oküler tutulumu olan ve olmayan Behçet hastalarının genel özellikleri, klinik ve demografik verileri sunulmuştur. Daha önceden bölgemizde benzer bir çalışma yapılmadığından verilerimizin hastaların tanı ve takiplerinde faydalı olacağı düşünülmüştür.

References

  • Behcet H. Uber rezidivivierende Aphthose, durch ein Virus verursachte Geschwure am Mund, am Auge und an den Genitalien. Dermatol Wochenschr 1937;105:1152-1157.
  • Yazici H, Fresko I, Yurdakul S. Behçet’s syndrome: disease manifestations, management, and advances in treatment. Nat Clin Pract Rheumatol 2007;3:148-155.
  • Sakane T, Takeno M, Suzuki N, Inaba G. Behçet’s disease. N Engl J Med 1999;341:1284-1291.
  • Mishima S, Masuda K, Izawa Y, et al. The eighth Freder- ick H. Verhoeff Lecture. presented by Saiichi Mishima, MD Behçet’s disease in Japan: ophthalmologic aspects. Trans Am Ophthalmol Soc 1979;77:225-279.
  • Saylan T, Mat C, Fresko I, Melikoğlu M. Behçet’s disease in the Middle East. Clin Dermatol 1999;17:209-223.
  • Nussenblatt RB, Whitcup SM, Palestine AG (1996) Be- hçet’s disease. In: Nussenblatt RB, Whitcup SM, Pales- tine AG (eds) Uveitis: fundamentals and clinical practice. Mosby, St Louis, pp 334-353.
  • Colvard DM, Robertson DM, O’Duffy JD. The ocular manifestations of Behçet’s disease. Arch Ophthalmol 1977;95:1813-1817.
  • International Study Group for Behçet’s Disease Evalu- ation of diagnostic (‘classification’) criteria in Behçet’s disease: toward internationally agreed criteria. Lancet 1990;335:1078-1080.
  • Verity DH, Marr JE, Ohno S, et al. Behçet’s disease, the Silk Road and HLA-B51: historical and geographical per- spectives. Tissue Antigens 1999;54:213-220.
  • Cingu AK, Onal S, Urgancioglu M, Tugal-Tutkun I. Com- parison of presenting features and three-year disease course in Turkish patients with Behçet uveitis who pre- sented in the early 1990s and the early 2000s. Ocul Im- munol Inflamm 2012;20:423-428.
  • Gürler A, İdil A, Boyvat A, Çalışkan D. AÜTF İbni Sina hastanesi Behçet Merkezine 1976-1997 yılları arasında başvuran 2175 olgunun cinse göre ilk semptom başlama yaşının değerlendirilmesi. Türkiye Klin Dermatoloji Derg 2000;10:83.
  • Tugal-Tutkun I, Onal S, Altan-Yaycioglu R, et al. Uveitis in Behçet disease: an analysis of 880 patients. Am J Oph- thalmol 2004;138:373-380.
  • Uslu M, Karaman G, Şavk E, ve ark. Aydında Behçet has- talığı deneyimi: 67 hastanın retrospektif değerlendirilmesi. ADÜ Tıp Fak Dergisi 2008;9:21-26.
  • Soylu M, Şekeroğlu HT, Erdem E, Demircan N. Behcet’s disease: The clinical and demographic characteristics of 406 patients. Turk J Rheumatol 2012;27:115-120.
  • Dogan B, Taskapan O, Harmanyeri Y. Prevalance of pathergy test positivity in Behçet’s disease in Turkey. J Eur Acad Dermatol Venereol 2003;17:228-229.
  • Tursen U, Gurler A, Boyvat A. Evaluation of clinical find- ings according to sex in 2313 Turkish patients with Be- hçet’s disease. Int J Dermatol 2003;42:346-351.
  • Gürler A, Boyvat A, Türsen U. Clinical manifestations of Behçet’s disease: an analysis of 2147 patients. Yonsei Med J 1997;38:423-427.
  • Sungur GK, Hazirolan D, Yalvac I, et al. Clinical and de- mographic evaluation of Behçet disease among different paediatric age groups. Br J Ophthalmol 2009;93:83-87.
  • Karincaoglu Y, Borlu M, Toker SC, et al. Demographic and clinical properties of juvenile-onset Behçet’s dis- ease: A controlled multicenter study. J Am Acad Dermatol 2008;58:579-584.
  • Sungur G, Hazirolan D, Hekimoglu E, et al. Late-onset Be- hçet’s disease: demographic, clinical, and ocular features. Graefes Arch Clin Exp Ophthalmol 2010;248:1325-1330.
There are 20 citations in total.

Details

Primary Language Turkish
Journal Section Research Article
Authors

Fatih Mehmet Türkcü This is me

Harun Yüksel This is me

Derya Uçmak This is me

Zeynep Meltem Akkurt This is me

Alparslan Şahin This is me

Yasin Çınar This is me

Abdullah Kürşat Cingü This is me

İhsan Çaça This is me

Publication Date September 1, 2013
Published in Issue Year 2013 Volume: 4 Issue: 3

Cite

APA Türkcü, F. M., Yüksel, H., Uçmak, D., Akkurt, Z. M., et al. (2013). Güneydoğu Anadolu bölgesindeki Behçet hastalarında oküler tutulum ve demografik özellikler. Journal of Clinical and Experimental Investigations, 4(3), 339-342. https://doi.org/10.5799/ahinjs.01.2013.03.0297
AMA Türkcü FM, Yüksel H, Uçmak D, Akkurt ZM, Şahin A, Çınar Y, Cingü AK, Çaça İ. Güneydoğu Anadolu bölgesindeki Behçet hastalarında oküler tutulum ve demografik özellikler. J Clin Exp Invest. September 2013;4(3):339-342. doi:10.5799/ahinjs.01.2013.03.0297
Chicago Türkcü, Fatih Mehmet, Harun Yüksel, Derya Uçmak, Zeynep Meltem Akkurt, Alparslan Şahin, Yasin Çınar, Abdullah Kürşat Cingü, and İhsan Çaça. “Güneydoğu Anadolu bölgesindeki Behçet hastalarında oküler Tutulum Ve Demografik özellikler”. Journal of Clinical and Experimental Investigations 4, no. 3 (September 2013): 339-42. https://doi.org/10.5799/ahinjs.01.2013.03.0297.
EndNote Türkcü FM, Yüksel H, Uçmak D, Akkurt ZM, Şahin A, Çınar Y, Cingü AK, Çaça İ (September 1, 2013) Güneydoğu Anadolu bölgesindeki Behçet hastalarında oküler tutulum ve demografik özellikler. Journal of Clinical and Experimental Investigations 4 3 339–342.
IEEE F. M. Türkcü, “Güneydoğu Anadolu bölgesindeki Behçet hastalarında oküler tutulum ve demografik özellikler”, J Clin Exp Invest, vol. 4, no. 3, pp. 339–342, 2013, doi: 10.5799/ahinjs.01.2013.03.0297.
ISNAD Türkcü, Fatih Mehmet et al. “Güneydoğu Anadolu bölgesindeki Behçet hastalarında oküler Tutulum Ve Demografik özellikler”. Journal of Clinical and Experimental Investigations 4/3 (September 2013), 339-342. https://doi.org/10.5799/ahinjs.01.2013.03.0297.
JAMA Türkcü FM, Yüksel H, Uçmak D, Akkurt ZM, Şahin A, Çınar Y, Cingü AK, Çaça İ. Güneydoğu Anadolu bölgesindeki Behçet hastalarında oküler tutulum ve demografik özellikler. J Clin Exp Invest. 2013;4:339–342.
MLA Türkcü, Fatih Mehmet et al. “Güneydoğu Anadolu bölgesindeki Behçet hastalarında oküler Tutulum Ve Demografik özellikler”. Journal of Clinical and Experimental Investigations, vol. 4, no. 3, 2013, pp. 339-42, doi:10.5799/ahinjs.01.2013.03.0297.
Vancouver Türkcü FM, Yüksel H, Uçmak D, Akkurt ZM, Şahin A, Çınar Y, Cingü AK, Çaça İ. Güneydoğu Anadolu bölgesindeki Behçet hastalarında oküler tutulum ve demografik özellikler. J Clin Exp Invest. 2013;4(3):339-42.