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Kolorektal kanserler: Tek merkez 12 yıllık sonuçları

Year 2013, Volume: 4 Issue: 2, 208 - 212, 01.06.2013
https://doi.org/10.5799/ahinjs.01.2013.02.0267

Abstract

Amaç: Bu çalışmamızda kliniğimizde takibi yapılmış olan kolorektal kanserli hastaların demografik, epidemiyolojik, klinik özellikleri ve sağkalımını etkileyen faktörlerin retros­pektif olarak belirlenmesi amaçlanmıştır. Yöntemler: Dicle Üniversitesi Tıp Fakültesi Tıbbi Onko­loji Bilim Dalı\'nda 2000- 2012 tarihleri arasında takip edil­miş 767 kolorektal kanser tanılı hasta retrospektif olarak değerlendirildi. Bulgular: Çalışmada hastaların 432\'si (%56,3) erkek, 335\'i( %43,7) kadın olup ortanca yaş 54 (11-94) idi. Ev­resine bakılan 725 hastanın 57\'si (%7,9) evre I, 230\'u (%31,7) evre II, 248\'i (%34,2) evre III ve 190\'u (%26,2) evre IV olarak tespit edildi. Tüm hastaların ortanca takip süresi 24.8 (1.5-154.1) aydı. Hastaların 275\'inde (%35.9) nüks veya progresyon, 184\'ünde (%24) ölüm gözlendi. Hastalıksız sağkalım oranları (HSK) %1,3 ve 5 yıllık %81, %62 ve %29 iken, genel sağkalım (GSK) oranları 1,3 ve 5 yıllık %88, %74 ve %49 idi. Yaş grubuna göre değer­lendirildiğinde 60 yaş ve altında olan hasta grubunda 60 yaş üstü gruba kıyasla hem HSK hem de GSK daha iyiydi (p=0.053 ve p=0.024). Evre ile HSK ve GSK arasında­da anlamlı farklılıklar görüldü (p

References

  • http://www.kanser.thsk.gov.tr. 04.04.2013.
  • Siegel R, Naishadham D, Jemal A. Cancer Statistics, 2013. CA CANCER J CLIN 2013;63:11-30.
  • Compton CC. Colorectal carcinoma: diagnostic, prognostic, and molecular features. Mod Pathol 2003;16:376-88.
  • O’Connell JB, Maggard MA, Ko CY. Colon cancer sur- vival rates with the new AJCC sixth edition staging. JNCI 2004;96:1420-1424.
  • Sökmen S. Kolorektal Kanserde Prognoz, Kolorektal Özel Sayısı. Türkiye Klinikleri J Surg 2004;9.57-65.
  • Dennis A.Casciato, Mary C. Terriato, Çeviri Editörü; Yalçin B. Klinik onkoloji el kitabı, Güneş Tıp Kitapevi, Ankara,2012,s;198-214.
  • Park YJ, Park KJ, Park JG, et al. Prognostic factors in 2230 Korean colorectal cancer patients: analy- sis of consecutively operated cases. World J Surg 1999;23:721-726.
  • Steven K. Libutti, Leonard B. Saltz, Christopher G. Willett. Cancer of the Colon. In Devita VT, Lawrence T, and Rosenberg SA (eds): Cancer: Principles and Practise of Oncology. 9th edition. Philadelphia Lippin- cott Williams &Wilkins;2011:1074-1127.
  • http://seer.cancer.gov/statfacts/html/colorect.html.04. 04.2013.
  • Storli KE, Sondenaa K, Bukholm IR, et al. Overall survival after resection for colon cancer in a national cohort study was adversely affected by TNM stage, lymph node ratio, gender, and old age. Int J Colorectal Dis 2011;26:1299-1307.
  • Quirke P, Williams GT, Ectors N, et al. The future of the TNM staging system in colorectal cancer: time for a debate? Lancet Oncol 2007;8:651-657.
  • Olariu A, Bartoş A, Bartoş D, et al. Evaluation of prognostic factors for colon cancer. Chirurgia (Bucur) 2012;107:174-179.
  • Janick Selves. Histological types and prognostic fac- tors in colorectal cancer. Med Sci (Paris) 2009;25:9-12.
  • Mekele J, Kiviniemi H, Laitinen S. Prognostic factors after surgery in patient younger than 50 years old with colorectal adenocarcinoma. Hepatogastroenterology 2002;49:971-975.
  • Burton S, Norman AR, Brown G, et al. Predictive poor prognostic factors in colonic carcinoma. Surg Oncol 2006;5:71-78.
  • National Cooperative Group on Pathology and Prog- nosis of Colorectal Cancer. Pathology and prognosis of colorectal cancer in Chinese young patients--an analysis of 319 cases. Zhonghua Zhong Liu Za Zhi 1996;8:146-148.
  • Wang WS, Chen PM, Chiou TJ, et al. Factors pre- dictive of survival in patients with node-positive colorectal cancer in Taiwan. Hepatogastroenterology 2000;47:1590-1594.

Colorectal cancers: 12 year-results of a single center

Year 2013, Volume: 4 Issue: 2, 208 - 212, 01.06.2013
https://doi.org/10.5799/ahinjs.01.2013.02.0267

Abstract

Objective: In this study, we aimed to investigate retrospec­tively demographic, epidemiological, clinical features, and the factors affecting survival of patients with colorectal can­cer who were followed up in our clinic. Methods: A total of 767 patients diagnosed with colorectal cancer, treated and followed up in Dicle University Medical Faculty, Department of Medical Oncology, between 2000 and 2012 were retrospectively evaluated. Results: A total of 767 patients [335 women (43.7%) and 432 men (56.3%)] were included in the study. The median age of the patients was 54 (range, 11-94). According to the stage of the tumor in 725 patients, 57 (7.9%) patients were in stage I, 230 (31.7) were in stage II, 248 (34.2) were in stage III and 190 (26.2%) were in stage IV. The median follow-up time for all the patients was 24.8 months (range: 1.5-154.1 months). There were recurrence or progression in 275 patients (35.9%) and there were death in 184 pa­tients (24%). Disease free survival (DFS) rates of 81%, 62% and 29%, respectively. The 1, 3 and 5 yearly overall survival (OS) rates were 88%, 74% and 49%, respectively. When we evaluated the patients according to the age group, un­der 60 years of age was better than over 60 years in term of DFS and OS (p=0.053 and p=0.024). A statistically sig­nificant difference was observed in the survival rates (DFS and OS) related to the stage of the disease. (p

References

  • http://www.kanser.thsk.gov.tr. 04.04.2013.
  • Siegel R, Naishadham D, Jemal A. Cancer Statistics, 2013. CA CANCER J CLIN 2013;63:11-30.
  • Compton CC. Colorectal carcinoma: diagnostic, prognostic, and molecular features. Mod Pathol 2003;16:376-88.
  • O’Connell JB, Maggard MA, Ko CY. Colon cancer sur- vival rates with the new AJCC sixth edition staging. JNCI 2004;96:1420-1424.
  • Sökmen S. Kolorektal Kanserde Prognoz, Kolorektal Özel Sayısı. Türkiye Klinikleri J Surg 2004;9.57-65.
  • Dennis A.Casciato, Mary C. Terriato, Çeviri Editörü; Yalçin B. Klinik onkoloji el kitabı, Güneş Tıp Kitapevi, Ankara,2012,s;198-214.
  • Park YJ, Park KJ, Park JG, et al. Prognostic factors in 2230 Korean colorectal cancer patients: analy- sis of consecutively operated cases. World J Surg 1999;23:721-726.
  • Steven K. Libutti, Leonard B. Saltz, Christopher G. Willett. Cancer of the Colon. In Devita VT, Lawrence T, and Rosenberg SA (eds): Cancer: Principles and Practise of Oncology. 9th edition. Philadelphia Lippin- cott Williams &Wilkins;2011:1074-1127.
  • http://seer.cancer.gov/statfacts/html/colorect.html.04. 04.2013.
  • Storli KE, Sondenaa K, Bukholm IR, et al. Overall survival after resection for colon cancer in a national cohort study was adversely affected by TNM stage, lymph node ratio, gender, and old age. Int J Colorectal Dis 2011;26:1299-1307.
  • Quirke P, Williams GT, Ectors N, et al. The future of the TNM staging system in colorectal cancer: time for a debate? Lancet Oncol 2007;8:651-657.
  • Olariu A, Bartoş A, Bartoş D, et al. Evaluation of prognostic factors for colon cancer. Chirurgia (Bucur) 2012;107:174-179.
  • Janick Selves. Histological types and prognostic fac- tors in colorectal cancer. Med Sci (Paris) 2009;25:9-12.
  • Mekele J, Kiviniemi H, Laitinen S. Prognostic factors after surgery in patient younger than 50 years old with colorectal adenocarcinoma. Hepatogastroenterology 2002;49:971-975.
  • Burton S, Norman AR, Brown G, et al. Predictive poor prognostic factors in colonic carcinoma. Surg Oncol 2006;5:71-78.
  • National Cooperative Group on Pathology and Prog- nosis of Colorectal Cancer. Pathology and prognosis of colorectal cancer in Chinese young patients--an analysis of 319 cases. Zhonghua Zhong Liu Za Zhi 1996;8:146-148.
  • Wang WS, Chen PM, Chiou TJ, et al. Factors pre- dictive of survival in patients with node-positive colorectal cancer in Taiwan. Hepatogastroenterology 2000;47:1590-1594.
There are 17 citations in total.

Details

Primary Language Turkish
Journal Section Research Article
Authors

Mehmet Küçüköner This is me

Muhammed Ali Kaplan This is me

Ali Inal This is me

Zuhat Urakci This is me

Necip Nas This is me

Abdurrahman Isikdogan This is me

Publication Date June 1, 2013
Published in Issue Year 2013 Volume: 4 Issue: 2

Cite

APA Küçüköner, M., Kaplan, M. A., Inal, A., Urakci, Z., et al. (2013). Kolorektal kanserler: Tek merkez 12 yıllık sonuçları. Journal of Clinical and Experimental Investigations, 4(2), 208-212. https://doi.org/10.5799/ahinjs.01.2013.02.0267
AMA Küçüköner M, Kaplan MA, Inal A, Urakci Z, Nas N, Isikdogan A. Kolorektal kanserler: Tek merkez 12 yıllık sonuçları. J Clin Exp Invest. June 2013;4(2):208-212. doi:10.5799/ahinjs.01.2013.02.0267
Chicago Küçüköner, Mehmet, Muhammed Ali Kaplan, Ali Inal, Zuhat Urakci, Necip Nas, and Abdurrahman Isikdogan. “Kolorektal Kanserler: Tek Merkez 12 yıllık sonuçları”. Journal of Clinical and Experimental Investigations 4, no. 2 (June 2013): 208-12. https://doi.org/10.5799/ahinjs.01.2013.02.0267.
EndNote Küçüköner M, Kaplan MA, Inal A, Urakci Z, Nas N, Isikdogan A (June 1, 2013) Kolorektal kanserler: Tek merkez 12 yıllık sonuçları. Journal of Clinical and Experimental Investigations 4 2 208–212.
IEEE M. Küçüköner, M. A. Kaplan, A. Inal, Z. Urakci, N. Nas, and A. Isikdogan, “Kolorektal kanserler: Tek merkez 12 yıllık sonuçları”, J Clin Exp Invest, vol. 4, no. 2, pp. 208–212, 2013, doi: 10.5799/ahinjs.01.2013.02.0267.
ISNAD Küçüköner, Mehmet et al. “Kolorektal Kanserler: Tek Merkez 12 yıllık sonuçları”. Journal of Clinical and Experimental Investigations 4/2 (June 2013), 208-212. https://doi.org/10.5799/ahinjs.01.2013.02.0267.
JAMA Küçüköner M, Kaplan MA, Inal A, Urakci Z, Nas N, Isikdogan A. Kolorektal kanserler: Tek merkez 12 yıllık sonuçları. J Clin Exp Invest. 2013;4:208–212.
MLA Küçüköner, Mehmet et al. “Kolorektal Kanserler: Tek Merkez 12 yıllık sonuçları”. Journal of Clinical and Experimental Investigations, vol. 4, no. 2, 2013, pp. 208-12, doi:10.5799/ahinjs.01.2013.02.0267.
Vancouver Küçüköner M, Kaplan MA, Inal A, Urakci Z, Nas N, Isikdogan A. Kolorektal kanserler: Tek merkez 12 yıllık sonuçları. J Clin Exp Invest. 2013;4(2):208-12.