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Ovarian malignant melanoma presenting with hypercalcemia and bone marrow infiltration: a case report and review of the literature

Year 2012, Volume: 3 Issue: 1, 96 - 98, 01.03.2012
https://doi.org/10.5799/ahinjs.01.2012.01.0119

Abstract

Malignant melanoma originating from the ovary is a very rare condition. Bone marrow involvement and hypercalcemia is observed at a very low rate in malignant melanoma cases (5-7 and 1.1-11.9%, respectively). In this paper, we present very rare condition as a 67-year-old female patient with malignant melanoma of ovary origin accompanied by bone marrow infiltration and hypercalcemia.

References

  • Rigel DS, Friedman RJ, Kopf AW. The incidence of malignant melanoma in the United States: issues as we approach the 21st century. J Am Acad Dermatol 1996;34(6):839-47.
  • Gungor T, Altinkaya SO, Ozat M, Bayramoglu H, Mol- lamahmutoglu L. Primary malignant melanoma of the female genital tract. Taiwan J Obstet Gynecol 2009;48(2):169-75.
  • Irvin WP Jr, Legallo RL, Stoler MH, et al. Vulvar mela- noma: a retrospective analysis and literature review. Gynecol Oncol 2001;83(3):457-65.
  • An JS, Wu LY, Li N, Li B, Yu GZ, Liu LY. Clinical anal- ysis of 42 cases of primary malignant melanoma in female genital tract. Zhonghua Fu Chan Ke Za Zhi 2007;42(5):320-4.
  • Wang Y, Chang W, Pu D. Clinical analysis of 15 pa- tients with primary malignant melanoma in the genital tract. Zhonghua Fu Chan Ke Za Zhi 1997;32(4):226-8.
  • Sugiyama VE, Chan JK, Kapp DS. Management of melanomas of the female genital tract. Curr Opin On- col 2008;20(3):565-9.
  • Batsis JA, Barry MJ. Metastatic malignant melano- ma presenting with hypercalcaemia and bone mar- row involvement. J Eur Acad Dermatol Venereol 2006;20(3):432-4.
  • Savage RA, Lucas FV, Hoffman GC. Melanoma in mar- row aspirates. Am J Clin Pathol 1983, 79(2):268-9.
  • Jain D, Singh T, Kumar N, Daga MK. Metastatic malig- nant melanoma in bone marrow with occult primary site - a case report with review of literature. Diagn Pathol 2007;2:38-41.
  • Gallivan MVE, Lokich JJ. Carcinocythemia (carcino- ma cell leukemia). Cancer 1984; 53(8):1100-2.
  • Basu D, Bhade BA, Ghotekar LH, Mathew T, Dutta TK. Malignant melanoma metastatic to bone marrow. Indian J Pathol Microbiol 2002;45(1):107-9.
  • Schadendorf D, Dorn-Beineke A, Borelli S, Riethmuller G, Pantel K. Limitations of the immunocytochemical detection of isolated tumor cells in frozen samples of bone marrow obtained from melanoma patients. Exp Dermatol 2003;12(1):165-71.
  • Uesawa M, Sato K, Ozaki K, Nagai T, Muroi K, Ozawa K. Bone marrow metastasis of malignant melanoma. Intern Med 2006;45(2):341-6.
  • Wong KF. Metastatic melanoma. Br J Haematol 2006;134(4):554-8.
  • Lumachi F, Brunello A, Roma A, Basso U. Medical treatment of malignancy-associated hypercalcemia. Curr Med Chem 2008;15(3):415-21.
  • Burt ME, Brennan MF. Hypercalcemia and malignant melanoma. Case reports. Am J Surg 1977;137(5):790- 4.
  • Levy I, Feun L. Hypercalcemia and malignant mela- noma. Am J Clin Oncol 1990;13(4):524-6.
  • Kageshita T, Matsui T, Hirai S, Fukuda Y, Ono T. Hy- percalcemia in melanoma patients associated with increased levels of parathyroid hormone-related pro- tein. Melanoma Res 1999;9(1):69-73.
  • McCluggage WG, Bissonnette JP, Young RH. Primary malignant melanoma of the ovary: a report of 9 defi- nite or probable cases with emphasis on their mor- phologic diversity and mimicry of other primary and secondary ovarian neoplasms. Int J Gynecol Pathol 2006;25(4):321-9.
  • McNeilage LJ, Morgan J, Constable J, Jobling TW. Metastatic malignant melanoma arising in a mature ovarian cystic teratoma: a case report and literature review. Int J Gynecol Cancer 2005; 15(10):1148-52.
  • Boscaino A, D’Antonio A, Orabona P, Tornillo L, Staibano S, De Rosa G. Primary malignant melanoma of the ovary. Pathologica 1995;87(6):685-8.
  • Brown D, Boniuk M, Font RL. Diffuse malignant melanoma of iris with metastases. Surv Ophthalmol 1990;34(5):357-64.
  • Tuncer I, Paydas¸ S, Cos¸ar EF, Ersöz C. Metastatic malignant melanoma in bone marrow: importance of aspiration cytology. Turk J Cancer 1994;24(2):168-70.
  • Bhagwati N, Seno R, Dutcher JP, Oleksowicz L. Ful- minant metastatic melanoma complicated by a mi- croangiopathic hemolytic anemia. Hematopathol Mol Hematol 1998; 11(2):101-8.

Hiperkalsemi ve kemik iliği infiltrasyonu ile başvuran bir overiyan malign melanom: vaka sunumu ve literatür taraması

Year 2012, Volume: 3 Issue: 1, 96 - 98, 01.03.2012
https://doi.org/10.5799/ahinjs.01.2012.01.0119

Abstract

Over kaynaklı malign melanom oldukça nadir bir durumdur. Kemik iliği tutulumu olması ve hiperkalsemi varlığı malign melanoma vakalarında çok düşük oranda gözlenmektedir (sırasıyla, % 5-7 and % 1.1-11.9). Bu yazıda biz de kemik iliği infiltrasyonu gösteren ve hiperkalsemisi bulunan oldukça nadir bir 67 yaşında kadın over kaynaklı malign melanoma vakasını sunduk.

References

  • Rigel DS, Friedman RJ, Kopf AW. The incidence of malignant melanoma in the United States: issues as we approach the 21st century. J Am Acad Dermatol 1996;34(6):839-47.
  • Gungor T, Altinkaya SO, Ozat M, Bayramoglu H, Mol- lamahmutoglu L. Primary malignant melanoma of the female genital tract. Taiwan J Obstet Gynecol 2009;48(2):169-75.
  • Irvin WP Jr, Legallo RL, Stoler MH, et al. Vulvar mela- noma: a retrospective analysis and literature review. Gynecol Oncol 2001;83(3):457-65.
  • An JS, Wu LY, Li N, Li B, Yu GZ, Liu LY. Clinical anal- ysis of 42 cases of primary malignant melanoma in female genital tract. Zhonghua Fu Chan Ke Za Zhi 2007;42(5):320-4.
  • Wang Y, Chang W, Pu D. Clinical analysis of 15 pa- tients with primary malignant melanoma in the genital tract. Zhonghua Fu Chan Ke Za Zhi 1997;32(4):226-8.
  • Sugiyama VE, Chan JK, Kapp DS. Management of melanomas of the female genital tract. Curr Opin On- col 2008;20(3):565-9.
  • Batsis JA, Barry MJ. Metastatic malignant melano- ma presenting with hypercalcaemia and bone mar- row involvement. J Eur Acad Dermatol Venereol 2006;20(3):432-4.
  • Savage RA, Lucas FV, Hoffman GC. Melanoma in mar- row aspirates. Am J Clin Pathol 1983, 79(2):268-9.
  • Jain D, Singh T, Kumar N, Daga MK. Metastatic malig- nant melanoma in bone marrow with occult primary site - a case report with review of literature. Diagn Pathol 2007;2:38-41.
  • Gallivan MVE, Lokich JJ. Carcinocythemia (carcino- ma cell leukemia). Cancer 1984; 53(8):1100-2.
  • Basu D, Bhade BA, Ghotekar LH, Mathew T, Dutta TK. Malignant melanoma metastatic to bone marrow. Indian J Pathol Microbiol 2002;45(1):107-9.
  • Schadendorf D, Dorn-Beineke A, Borelli S, Riethmuller G, Pantel K. Limitations of the immunocytochemical detection of isolated tumor cells in frozen samples of bone marrow obtained from melanoma patients. Exp Dermatol 2003;12(1):165-71.
  • Uesawa M, Sato K, Ozaki K, Nagai T, Muroi K, Ozawa K. Bone marrow metastasis of malignant melanoma. Intern Med 2006;45(2):341-6.
  • Wong KF. Metastatic melanoma. Br J Haematol 2006;134(4):554-8.
  • Lumachi F, Brunello A, Roma A, Basso U. Medical treatment of malignancy-associated hypercalcemia. Curr Med Chem 2008;15(3):415-21.
  • Burt ME, Brennan MF. Hypercalcemia and malignant melanoma. Case reports. Am J Surg 1977;137(5):790- 4.
  • Levy I, Feun L. Hypercalcemia and malignant mela- noma. Am J Clin Oncol 1990;13(4):524-6.
  • Kageshita T, Matsui T, Hirai S, Fukuda Y, Ono T. Hy- percalcemia in melanoma patients associated with increased levels of parathyroid hormone-related pro- tein. Melanoma Res 1999;9(1):69-73.
  • McCluggage WG, Bissonnette JP, Young RH. Primary malignant melanoma of the ovary: a report of 9 defi- nite or probable cases with emphasis on their mor- phologic diversity and mimicry of other primary and secondary ovarian neoplasms. Int J Gynecol Pathol 2006;25(4):321-9.
  • McNeilage LJ, Morgan J, Constable J, Jobling TW. Metastatic malignant melanoma arising in a mature ovarian cystic teratoma: a case report and literature review. Int J Gynecol Cancer 2005; 15(10):1148-52.
  • Boscaino A, D’Antonio A, Orabona P, Tornillo L, Staibano S, De Rosa G. Primary malignant melanoma of the ovary. Pathologica 1995;87(6):685-8.
  • Brown D, Boniuk M, Font RL. Diffuse malignant melanoma of iris with metastases. Surv Ophthalmol 1990;34(5):357-64.
  • Tuncer I, Paydas¸ S, Cos¸ar EF, Ersöz C. Metastatic malignant melanoma in bone marrow: importance of aspiration cytology. Turk J Cancer 1994;24(2):168-70.
  • Bhagwati N, Seno R, Dutcher JP, Oleksowicz L. Ful- minant metastatic melanoma complicated by a mi- croangiopathic hemolytic anemia. Hematopathol Mol Hematol 1998; 11(2):101-8.
There are 24 citations in total.

Details

Primary Language Turkish
Journal Section Case Report
Authors

Muhammet Ali Kaplan This is me

Mehmet Küçüköner This is me

Ali İnal This is me

Abdurrahman Işıkdoğan This is me

Zuhat Urakçı This is me

Publication Date March 1, 2012
Published in Issue Year 2012 Volume: 3 Issue: 1

Cite

APA Kaplan, M. A., Küçüköner, M., İnal, A., Işıkdoğan, A., et al. (2012). Hiperkalsemi ve kemik iliği infiltrasyonu ile başvuran bir overiyan malign melanom: vaka sunumu ve literatür taraması. Journal of Clinical and Experimental Investigations, 3(1), 96-98. https://doi.org/10.5799/ahinjs.01.2012.01.0119
AMA Kaplan MA, Küçüköner M, İnal A, Işıkdoğan A, Urakçı Z. Hiperkalsemi ve kemik iliği infiltrasyonu ile başvuran bir overiyan malign melanom: vaka sunumu ve literatür taraması. J Clin Exp Invest. March 2012;3(1):96-98. doi:10.5799/ahinjs.01.2012.01.0119
Chicago Kaplan, Muhammet Ali, Mehmet Küçüköner, Ali İnal, Abdurrahman Işıkdoğan, and Zuhat Urakçı. “Hiperkalsemi Ve Kemik iliği Infiltrasyonu Ile başvuran Bir Overiyan Malign Melanom: Vaka Sunumu Ve literatür Taraması”. Journal of Clinical and Experimental Investigations 3, no. 1 (March 2012): 96-98. https://doi.org/10.5799/ahinjs.01.2012.01.0119.
EndNote Kaplan MA, Küçüköner M, İnal A, Işıkdoğan A, Urakçı Z (March 1, 2012) Hiperkalsemi ve kemik iliği infiltrasyonu ile başvuran bir overiyan malign melanom: vaka sunumu ve literatür taraması. Journal of Clinical and Experimental Investigations 3 1 96–98.
IEEE M. A. Kaplan, M. Küçüköner, A. İnal, A. Işıkdoğan, and Z. Urakçı, “Hiperkalsemi ve kemik iliği infiltrasyonu ile başvuran bir overiyan malign melanom: vaka sunumu ve literatür taraması”, J Clin Exp Invest, vol. 3, no. 1, pp. 96–98, 2012, doi: 10.5799/ahinjs.01.2012.01.0119.
ISNAD Kaplan, Muhammet Ali et al. “Hiperkalsemi Ve Kemik iliği Infiltrasyonu Ile başvuran Bir Overiyan Malign Melanom: Vaka Sunumu Ve literatür Taraması”. Journal of Clinical and Experimental Investigations 3/1 (March 2012), 96-98. https://doi.org/10.5799/ahinjs.01.2012.01.0119.
JAMA Kaplan MA, Küçüköner M, İnal A, Işıkdoğan A, Urakçı Z. Hiperkalsemi ve kemik iliği infiltrasyonu ile başvuran bir overiyan malign melanom: vaka sunumu ve literatür taraması. J Clin Exp Invest. 2012;3:96–98.
MLA Kaplan, Muhammet Ali et al. “Hiperkalsemi Ve Kemik iliği Infiltrasyonu Ile başvuran Bir Overiyan Malign Melanom: Vaka Sunumu Ve literatür Taraması”. Journal of Clinical and Experimental Investigations, vol. 3, no. 1, 2012, pp. 96-98, doi:10.5799/ahinjs.01.2012.01.0119.
Vancouver Kaplan MA, Küçüköner M, İnal A, Işıkdoğan A, Urakçı Z. Hiperkalsemi ve kemik iliği infiltrasyonu ile başvuran bir overiyan malign melanom: vaka sunumu ve literatür taraması. J Clin Exp Invest. 2012;3(1):96-8.