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Essential tremor responsive to levetiracetam

Year 2012, Volume: 3 Issue: 1, 108 - 110, 01.03.2012
https://doi.org/10.5799/ahinjs.01.2012.01.0123

Abstract

Essential tremor is one of the most common movement disorders with a prevalence of 0.4% to 3.9% in the general population and increases with age. The medical treatment available for patients with essential tremor is often inadequate. Propranolol and primidone are the first-line treatment options, improving in up to two thirds of cases. This article reports a satisfying response to levetiracetam with disabling essential tremor in a 58-year-old man whom propranolol as well as primidone had to be discontinued due to unresponsiveness and severe side effects. One of the antiepileptic drugs, levetiracetam, may be more useful in the treatment of essential tremor.

References

  • Whaley NR, Putzke JD, Baba Y, Wszolek ZK, Uitti RJ. Essential tremor: phenotypic expression in a clinical cohort. Parkinsonism Relat Disord 2007; 13(6):333–9.
  • Louis ED. Clinical practice: Essential tremor. N Engl J Med 2001; 345(12):887-91.
  • Fahn SE, Tolosa E, Marin C. Clinical rating scale for tremor. In: Jankovic J, Tolosa E, eds. Parkinson’s Dis- ease and Movement Disorders, 2nd edn. Baltimore: Williams & Wilkins, 1998:225-34.
  • Johannessen Landmark C. Antiepileptic drugs in non- epilepsy disorders: relations between mechanisms of action and clinical efficacy. CNS Drugs 2008; 22(1):27-47.
  • Ondo WG. Essential tremor: treatment options. Curr Treat Options Neurol 2006; 8(3):256-67.
  • Sanz-Cartagena P, Fossas P, Floriach-Robert M, Cano A, Palomeras E. Effectiveness and safety of leveti- racetam in patients with essential tremor: data from an open 11-week follow-up trial. Rev Neurol 2007; 45(3):134-6.
  • Kralic JE, Criswell HE, Osterman JL, et al. Genetic es- sential tremor in gamma-aminobutyric acidA receptor alpha1 subunit knockout mice. J Clin Invest 2005; 115(3):774-9.
  • Saponara R, Greco S, Proto G, Trubia T, Domina E. Levetiracetam improves intention tremor in fragile x- associated tremor/ataxia syndrome. Clin Neurophar- macol 2009; 32(1):53-4.
  • Ferlazzo E, Morgante F, Rizzo V, et al. Successful treat- ment of Holmes tremor by levetiracetam. Mov Disord 2008; 23(14):2101-3.
  • Bushara KO, Malik T, Exconde RE. The effect of le- vetiracetam on essential tremor. Neurology 2005; 64(6):1078-80.
  • Elble RJ, Lyons KE, Pahwa R. Levetiracetam is not effective for essential tremor. Clin Neuropharmacol 2007; 30(6):350-6.

Levetirasetama cevap veren esansiyel tremor

Year 2012, Volume: 3 Issue: 1, 108 - 110, 01.03.2012
https://doi.org/10.5799/ahinjs.01.2012.01.0123

Abstract

Esansiyel tremor, genel popülasyonda prevelansı % 0.4-3.9 olan ve yaş ile artan en sık görülen hareket bozukluğudur. Esansiyel tremorlu hastaların medikal tedavileri sıklıkla yetersizdir. Propranolol ve primidon vakaların 2/3\'de ilk tercih tedavilerdir. Bu yazı, propranolol ve primidonu yanıtsızlık ve yan etkiler nedeni ile kesilen levetirasetama iyi cevap veren sakatlayıcı esansiyel tremorlu 58 yaşındaki bir erkek hastayı rapor etmektedir. Antiepileptik ilaçlardan biri olan levetirasetam, esansiyel tremor tedavisinde daha fazla yararlı olabilmektedir.

References

  • Whaley NR, Putzke JD, Baba Y, Wszolek ZK, Uitti RJ. Essential tremor: phenotypic expression in a clinical cohort. Parkinsonism Relat Disord 2007; 13(6):333–9.
  • Louis ED. Clinical practice: Essential tremor. N Engl J Med 2001; 345(12):887-91.
  • Fahn SE, Tolosa E, Marin C. Clinical rating scale for tremor. In: Jankovic J, Tolosa E, eds. Parkinson’s Dis- ease and Movement Disorders, 2nd edn. Baltimore: Williams & Wilkins, 1998:225-34.
  • Johannessen Landmark C. Antiepileptic drugs in non- epilepsy disorders: relations between mechanisms of action and clinical efficacy. CNS Drugs 2008; 22(1):27-47.
  • Ondo WG. Essential tremor: treatment options. Curr Treat Options Neurol 2006; 8(3):256-67.
  • Sanz-Cartagena P, Fossas P, Floriach-Robert M, Cano A, Palomeras E. Effectiveness and safety of leveti- racetam in patients with essential tremor: data from an open 11-week follow-up trial. Rev Neurol 2007; 45(3):134-6.
  • Kralic JE, Criswell HE, Osterman JL, et al. Genetic es- sential tremor in gamma-aminobutyric acidA receptor alpha1 subunit knockout mice. J Clin Invest 2005; 115(3):774-9.
  • Saponara R, Greco S, Proto G, Trubia T, Domina E. Levetiracetam improves intention tremor in fragile x- associated tremor/ataxia syndrome. Clin Neurophar- macol 2009; 32(1):53-4.
  • Ferlazzo E, Morgante F, Rizzo V, et al. Successful treat- ment of Holmes tremor by levetiracetam. Mov Disord 2008; 23(14):2101-3.
  • Bushara KO, Malik T, Exconde RE. The effect of le- vetiracetam on essential tremor. Neurology 2005; 64(6):1078-80.
  • Elble RJ, Lyons KE, Pahwa R. Levetiracetam is not effective for essential tremor. Clin Neuropharmacol 2007; 30(6):350-6.
There are 11 citations in total.

Details

Primary Language Turkish
Journal Section Case Report
Authors

Aysel Milanlıoğlu This is me

Ömer Faruk Odabaş This is me

Abdullah Yılgör This is me

Publication Date March 1, 2012
Published in Issue Year 2012 Volume: 3 Issue: 1

Cite

APA Milanlıoğlu, A., Odabaş, Ö. F., & Yılgör, A. (2012). Levetirasetama cevap veren esansiyel tremor. Journal of Clinical and Experimental Investigations, 3(1), 108-110. https://doi.org/10.5799/ahinjs.01.2012.01.0123
AMA Milanlıoğlu A, Odabaş ÖF, Yılgör A. Levetirasetama cevap veren esansiyel tremor. J Clin Exp Invest. March 2012;3(1):108-110. doi:10.5799/ahinjs.01.2012.01.0123
Chicago Milanlıoğlu, Aysel, Ömer Faruk Odabaş, and Abdullah Yılgör. “Levetirasetama Cevap Veren Esansiyel Tremor”. Journal of Clinical and Experimental Investigations 3, no. 1 (March 2012): 108-10. https://doi.org/10.5799/ahinjs.01.2012.01.0123.
EndNote Milanlıoğlu A, Odabaş ÖF, Yılgör A (March 1, 2012) Levetirasetama cevap veren esansiyel tremor. Journal of Clinical and Experimental Investigations 3 1 108–110.
IEEE A. Milanlıoğlu, Ö. F. Odabaş, and A. Yılgör, “Levetirasetama cevap veren esansiyel tremor”, J Clin Exp Invest, vol. 3, no. 1, pp. 108–110, 2012, doi: 10.5799/ahinjs.01.2012.01.0123.
ISNAD Milanlıoğlu, Aysel et al. “Levetirasetama Cevap Veren Esansiyel Tremor”. Journal of Clinical and Experimental Investigations 3/1 (March 2012), 108-110. https://doi.org/10.5799/ahinjs.01.2012.01.0123.
JAMA Milanlıoğlu A, Odabaş ÖF, Yılgör A. Levetirasetama cevap veren esansiyel tremor. J Clin Exp Invest. 2012;3:108–110.
MLA Milanlıoğlu, Aysel et al. “Levetirasetama Cevap Veren Esansiyel Tremor”. Journal of Clinical and Experimental Investigations, vol. 3, no. 1, 2012, pp. 108-10, doi:10.5799/ahinjs.01.2012.01.0123.
Vancouver Milanlıoğlu A, Odabaş ÖF, Yılgör A. Levetirasetama cevap veren esansiyel tremor. J Clin Exp Invest. 2012;3(1):108-10.