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p-ANCA and c-ANCA frequency and their relationship with other diseases in patients with lung cancer

Year 2011, Volume: 2 Issue: 4, 384 - 387, 01.12.2011
https://doi.org/10.5799/ahinjs.01.2011.04.0077

Abstract

Objectives: In this study, we aimed to investigate the association of cancer with vasculitis and the frequency of cancer-related paraneoplastic syndromes and their relationship by measuring blood levels of Perinuclear type Anti-Neutrophilic Cytoplasmic Antibody (p-ANCA) and Cytoplasmic type antineutrophil cytoplasmic antibodies (c-ANCA) in patients with lung cancer and asthma and in healthy individuals. Materials and methods: 20 patients diagnosed with asthma, 26 patients following up with a diagnosis of lung cancer and control group of 20 healthy individuals were enrolled in this study. ANCA levels were measured in blood samples. Results: Borderline positive c-ANCA detected in 1 of 26 patients and 1/32 percent were positive detected in one patient. Borderline positive p-ANCA detected in 1 of 26 patients and 1/32 percent were positive detected in 1 patient. p-ANCA was positive detected in 2/20 of asthmatic patient and c-ANCA was borderline positive detected in 1/20 asthma patient. In asthma and cancer patients, physical examinations and pathological findings did not support the vasculitis. Only one subject in the control group was found to be borderline positive for c-ANCA. Conclusion: As a result, in some of the patients the positivity of ANCA was detected not related with vasculitis and paraneoplastic findings. Because of this, vasculitis should be considered in differential diagnosis of the patients whom considered as malignancy. J Clin Exp Invest 2011; 2 (4): 384-387

References

  • Fain O, Hamidou M. Vasculitides associated with ma- lignancies: analysis of sixty patients. Arthritis Rheum 2007; 57(10): 1473-80.
  • Fortin PR. Vasculitides associated with malignancy. Curr Opin Rheumatol 1996; 8(1): 30-3.
  • Çimen R. Küçük hücreli akciğer kanseri ve lökositok- lastik vaskülit. Solunum Hastalıkları 2001; 12(2): 146- 150.
  • Wartz H, Hammerl P. Bronchioloalveolar carcinoma of the lung associated with a highly positive p-ANCA- titer and clinical signs of microscopic polyangiitis]. Pneumologie 2004; 58(3): 493-8.
  • Baschinsky Dy, Baker PB. Pauci immune ANCA posi- tive crescentic glomerulonephritis associated with metastatic adenocarcinosa of lung, Am J Kidney Dis 2000; 36(1); E24.
  • Morisako T,Tsuchida F. Squamous cellcarcinoma of the lung with a high titer of proteinase 3 antineutrophil cytoplasmic antibody. Nihon Kokyuki Gakki Zosschi 2006: 44(1): 139-41.
  • Ertürk A, Ulukavak T, Demirağ F ve ark. Wegener gra- nülomatozisi. (akciğer tüberkülozunu ve kanserini taklit eden bir olgu nedeniyle). Tüberküloz ve Toraks Dergisi 1998; 46(2): 269-73.
  • Öziş T, Köktürk N. Metastatik akciğer kanserini taklit eden bir Wegener granülomatozisi olgusu. Akciğer Ar- şivi: 2003; 4(2): 146-50.
  • Ergün P, Biber Ç, Erdoğan Y ve ark. Wegener granülo- matozisi: sekiz olgunun değerlendirilmesi. Tüberküloz ve Toraks Dergisi 2001;49(3):477-82.

p-ANCA and c-ANCA frequency and their relationship with other diseases in patients with lung cancer

Year 2011, Volume: 2 Issue: 4, 384 - 387, 01.12.2011
https://doi.org/10.5799/ahinjs.01.2011.04.0077

Abstract

Amaç: Akciğer kanseri ve astım hastaları ile sağlıklı bireylerin kan perinükleer tip Anti Nötrofilik Sitoplazmik Antikor (p-ANCA) ve sitoplazmik tip Anti Nötrofilik Sitoplazmik Antikor (c-ANCA) seviyeleri ölçülerek bu hastalarda p-ANCA ve c-ANCA sıklığı ve kansere bağlı paraneoplastik sendromlarla olan ilişkisini, kanser-vaskülit birlikteliğinin araştırılmasını amaçladık. Gereç ve yöntem: Çalışmaya astım tanısı alan 20 hasta, akciğer kanseri tanısı ile takip edilen 26 hasta, kontrol grubu olarak da herhangi bir hastalık saptanmayan 20 sağlıklı birey alındı. Kan örneklerinden p-ANCA ve c-ANCA seviyeleri ölçüldü. Bulgular: Akciğer kanserli 26 hastadan 1\'inde c-ANCA sınırda pozitif, 1\'inde 1/32 pozitif saptandı. Yine akciğer kanserli 26 hastanın birinde p-ANCA 1/32 pozitif, 1 hastada ise sınırda pozitif olarak saptandı. Astımlı 20 hastanın 2 tanesinde p-ANCA pozitif, 1 hastada c-ANCA sınırda pozitif olarak saptandı. Astımlı ve kanserli hastalarda vasküliti destekleyen fizik muayene ve patoloji bulgularına rastlanmadı. Kontrol grubundaki 20 sağlıklı bireyden sadece 1 tanesinde c-ANCA sınırda pozitif olarak saptandı. Sonuç: Hastaların bir kısmında vaskülit ve paraneoplastik bulgulardan bağımsız olarak ANCA pozitifliği saptandı. Bu nedenle malignite düşünülen hastalarda ayrıcı tanıda vaskülitler de göz önünde tutulmalıdır.

References

  • Fain O, Hamidou M. Vasculitides associated with ma- lignancies: analysis of sixty patients. Arthritis Rheum 2007; 57(10): 1473-80.
  • Fortin PR. Vasculitides associated with malignancy. Curr Opin Rheumatol 1996; 8(1): 30-3.
  • Çimen R. Küçük hücreli akciğer kanseri ve lökositok- lastik vaskülit. Solunum Hastalıkları 2001; 12(2): 146- 150.
  • Wartz H, Hammerl P. Bronchioloalveolar carcinoma of the lung associated with a highly positive p-ANCA- titer and clinical signs of microscopic polyangiitis]. Pneumologie 2004; 58(3): 493-8.
  • Baschinsky Dy, Baker PB. Pauci immune ANCA posi- tive crescentic glomerulonephritis associated with metastatic adenocarcinosa of lung, Am J Kidney Dis 2000; 36(1); E24.
  • Morisako T,Tsuchida F. Squamous cellcarcinoma of the lung with a high titer of proteinase 3 antineutrophil cytoplasmic antibody. Nihon Kokyuki Gakki Zosschi 2006: 44(1): 139-41.
  • Ertürk A, Ulukavak T, Demirağ F ve ark. Wegener gra- nülomatozisi. (akciğer tüberkülozunu ve kanserini taklit eden bir olgu nedeniyle). Tüberküloz ve Toraks Dergisi 1998; 46(2): 269-73.
  • Öziş T, Köktürk N. Metastatik akciğer kanserini taklit eden bir Wegener granülomatozisi olgusu. Akciğer Ar- şivi: 2003; 4(2): 146-50.
  • Ergün P, Biber Ç, Erdoğan Y ve ark. Wegener granülo- matozisi: sekiz olgunun değerlendirilmesi. Tüberküloz ve Toraks Dergisi 2001;49(3):477-82.
There are 9 citations in total.

Details

Primary Language Turkish
Journal Section Research Article
Authors

Ahmet Yılmaz This is me

Hatice Yılmaz This is me

Publication Date December 1, 2011
Published in Issue Year 2011 Volume: 2 Issue: 4

Cite

APA Yılmaz, A., & Yılmaz, H. (2011). p-ANCA and c-ANCA frequency and their relationship with other diseases in patients with lung cancer. Journal of Clinical and Experimental Investigations, 2(4), 384-387. https://doi.org/10.5799/ahinjs.01.2011.04.0077
AMA Yılmaz A, Yılmaz H. p-ANCA and c-ANCA frequency and their relationship with other diseases in patients with lung cancer. J Clin Exp Invest. December 2011;2(4):384-387. doi:10.5799/ahinjs.01.2011.04.0077
Chicago Yılmaz, Ahmet, and Hatice Yılmaz. “P-ANCA and C-ANCA Frequency and Their Relationship With Other Diseases in Patients With Lung Cancer”. Journal of Clinical and Experimental Investigations 2, no. 4 (December 2011): 384-87. https://doi.org/10.5799/ahinjs.01.2011.04.0077.
EndNote Yılmaz A, Yılmaz H (December 1, 2011) p-ANCA and c-ANCA frequency and their relationship with other diseases in patients with lung cancer. Journal of Clinical and Experimental Investigations 2 4 384–387.
IEEE A. Yılmaz and H. Yılmaz, “p-ANCA and c-ANCA frequency and their relationship with other diseases in patients with lung cancer”, J Clin Exp Invest, vol. 2, no. 4, pp. 384–387, 2011, doi: 10.5799/ahinjs.01.2011.04.0077.
ISNAD Yılmaz, Ahmet - Yılmaz, Hatice. “P-ANCA and C-ANCA Frequency and Their Relationship With Other Diseases in Patients With Lung Cancer”. Journal of Clinical and Experimental Investigations 2/4 (December 2011), 384-387. https://doi.org/10.5799/ahinjs.01.2011.04.0077.
JAMA Yılmaz A, Yılmaz H. p-ANCA and c-ANCA frequency and their relationship with other diseases in patients with lung cancer. J Clin Exp Invest. 2011;2:384–387.
MLA Yılmaz, Ahmet and Hatice Yılmaz. “P-ANCA and C-ANCA Frequency and Their Relationship With Other Diseases in Patients With Lung Cancer”. Journal of Clinical and Experimental Investigations, vol. 2, no. 4, 2011, pp. 384-7, doi:10.5799/ahinjs.01.2011.04.0077.
Vancouver Yılmaz A, Yılmaz H. p-ANCA and c-ANCA frequency and their relationship with other diseases in patients with lung cancer. J Clin Exp Invest. 2011;2(4):384-7.