BibTex RIS Cite

Comparison of effectiveness of bupivacaine and levobupivacaine used in spinal anesthesia

Year 2011, Volume: 2 Issue: 4, 388 - 391, 01.12.2011
https://doi.org/10.5799/ahinjs.01.2011.04.0078

Abstract

Objectives: In this study, the effectiveness of bupivacaine and levobupivacaine was evaluated in spinal anesthesia. Materials and methods: Applied lower extremity surgery under spinal anesthesia with bupivacaine and levobupivacaine, ASA I-III group, between 18-65 years patients were evaluated. The patients were divided into two groups according to used the local anesthetic drugs. Group B to 12.5 mg 0.5% bupivacaine + 10 mcg fentanyl (total 2.6 ml), Group L to 12.5 mg of 0.5% levobupivacaine + 10 mcg fentanyl (total 2.6 ml) was given. Patient demographics, clinical diagnoses, used local anesthetics dose and volume, duration of surgery, duration of sensory and motor block, hemodynamic parameters before and after the intervention, the first postoperative analgesic requirements, complications during and after treatment, patient satisfaction and surgical data were recorded. Results: 260 patients were included in the study. The demographic data were similar. The local anesthetic activity, in terms of hemodynamic parameters and duration of sensory block was not different between two drugs, but the motor block regression time was found to be longer in bupivacaine group. Conclusion: Llevobupivacaine might be a good alternative to bupivacaine for spinal anesthesia because it causes less motor block than bupivacaine. J Clin Exp Invest 2011; 2 (4): 388-390

References

  • Kadıoğlu AG, Özgür M, Özkaya G ve ark. Spinal anes- tezi uygulamalarımızın karakteristikleri ile sonuçla- rının retrospektif değerlendirilmesi. Anestezi Dergisi 2011; 19(1):20-5
  • Kayaalp O. Tıbbı Farmakoloji. 8. Baskı. Ankara, Hac- cettepe Taş Kitapçılık 1998.
  • Swester S, Olin BR. Drug factors and comparison. Phil- adelphia, Medical Comp 1996;285
  • Glaser C, Marhofer P, Zimpfer G, et al. Levobupivic- aine versus racemic bupivicaine for spinal anesthesia. Anesth Analg 2002; 94(2): 194–8.
  • Morrison SG, Dominguez JJ, Frascarolo P, Reiz S. A comparison of the electrocardiographic cardiotoxic effects of racemic bupivacaine, levobupivacaine and ropivacaine in anesthetized swine. Anesth Analg 2000; 90(6):1308-14.
  • Morgan GE, Jr Maged SM. Clinical Anestesiology, 2nd Ed. Appleton Lange, USA 1996; 200-11.
  • Fattorini F, Ricci Z, Rocco A, et al. Levobupivacaine versus racemic bupivacaine forspinal anaesthesia in orthopaedic major surgery. Minerva Anestesiol 2006; 72(5): 637–44.
  • Lee YY, Muchhal K, Chan CK. Levobupivacaine versus racemic bupivacaine in spinal anaesthesia for urologi- cal surgery. Anaesth Intensive Care 2003;31(4):637– 41.
  • Hamber EA, Viscomi CM. Intrathecal lipophilic opioids as adjuncts to surgical spinal anesthesia. Reg Anesth Pain Med 1999; 24(2): 255–263.
  • Ben-David B, Miller G, Gavriel R, Gurevitch A. Low- dose bupivacaine-fentanyl spinal anesthesia for ce- sarean delivery. Reg Anesth Pain Med 2000; 25(2): 235–39.
  • Siddik-Sayyid SM, Aouad MT, Jalbout MI, Zalaket MI, Berzina CE, Baraka AS: Intrathecal versus intrave- nous fentanyl for supplementation of subarachnoid block during cesarean delivery. Anesth Analg 2002; 95(2): 209-13.
  • Liao RZ, Peng JH, Chen YX, et al. Comparison of the block characteristics of levobupivacaine vs bupi- vacaine for unilateral spinal block. Di Yi Jun Yi Da Xue XueBao 2005; 25(10): 1563–7.
  • Erbay RH, Ermumcu O, Hanci V, et al. A compari- son of spinal anesthesiae with low-dose hyperbaric levobupivacaine and hyperbaric bupivacaine for tran- suretral surgery:a randomized controlled trial. Minevra Anestesiol 2010;76(9):992-1001.
  • Arslantaş R, Arşlantaş MK, Şitilci T ve ark. Ürolojik girişimlerde bupivakain ile levobupivakainin karşılaştı- rılması. TARD dergisi 2006; 257(2): 156-9.

Comparison of effectiveness of bupivacaine and levobupivacaine used in spinal anesthesia

Year 2011, Volume: 2 Issue: 4, 388 - 391, 01.12.2011
https://doi.org/10.5799/ahinjs.01.2011.04.0078

Abstract

Amaç: Spinal anestezide uygulanan bupivakain ve levobupivakainin etkinliklerinin karşılaştırılması amaçlandı. Gereç ve yöntem: Alt ekstremite cerrahisi geçiren, ASA I-III grubu, 18-65 yaş arası spinal anestezide bupivakain ve levobupivakain uygulanmış hastalar retrospektif olarak incelendi. Hastalar kullanılan lokal anestezik ilaçlara göre iki gruba ayrıldı. Grup B' ye 12,5 mg % 0.5 bupivakain + 10 mcg fentanil (toplam 2.6 ml), Grup L' ye 12,5 mg % 0.5 levobupivakain + 10 mcg fentanil (toplam 2.6 ml) verildi. Hastaların demografik özellikleri, klinik tanıları, kullanılan lokal anestezik dozu ve volümü, cerrahi sureler, duyusal ve motor blok süreleri girişim öncesi ve sonrası hemodinamik parametreler, ek analjezik ihtiyaçları, postoperatif ilk analjezik gereksinimleri, işlem esnasında ve sonrasında gelişen komplikasyonlar, hasta ve cerrahi memnuniyet verileri kaydedildi. Bulgular: Çalışmaya 260 hasta dahil edildi. Demoğrafik veriler benzerdi. Lokal anestezik etkinlikleri, hemodinamik parametreler ve duyusal blok süreleri bakımından her iki ilacın farksız olduğu ancak motor blok gerileme zamanının bupivakain grubunda daha uzun olduğu gözlendi. Sonuç: Levobupivakain daha az motor bloğa neden olduğundan, spinal anestezide bupivakaine iyi bir alternatif olabileceğini düşünmekteyiz.

References

  • Kadıoğlu AG, Özgür M, Özkaya G ve ark. Spinal anes- tezi uygulamalarımızın karakteristikleri ile sonuçla- rının retrospektif değerlendirilmesi. Anestezi Dergisi 2011; 19(1):20-5
  • Kayaalp O. Tıbbı Farmakoloji. 8. Baskı. Ankara, Hac- cettepe Taş Kitapçılık 1998.
  • Swester S, Olin BR. Drug factors and comparison. Phil- adelphia, Medical Comp 1996;285
  • Glaser C, Marhofer P, Zimpfer G, et al. Levobupivic- aine versus racemic bupivicaine for spinal anesthesia. Anesth Analg 2002; 94(2): 194–8.
  • Morrison SG, Dominguez JJ, Frascarolo P, Reiz S. A comparison of the electrocardiographic cardiotoxic effects of racemic bupivacaine, levobupivacaine and ropivacaine in anesthetized swine. Anesth Analg 2000; 90(6):1308-14.
  • Morgan GE, Jr Maged SM. Clinical Anestesiology, 2nd Ed. Appleton Lange, USA 1996; 200-11.
  • Fattorini F, Ricci Z, Rocco A, et al. Levobupivacaine versus racemic bupivacaine forspinal anaesthesia in orthopaedic major surgery. Minerva Anestesiol 2006; 72(5): 637–44.
  • Lee YY, Muchhal K, Chan CK. Levobupivacaine versus racemic bupivacaine in spinal anaesthesia for urologi- cal surgery. Anaesth Intensive Care 2003;31(4):637– 41.
  • Hamber EA, Viscomi CM. Intrathecal lipophilic opioids as adjuncts to surgical spinal anesthesia. Reg Anesth Pain Med 1999; 24(2): 255–263.
  • Ben-David B, Miller G, Gavriel R, Gurevitch A. Low- dose bupivacaine-fentanyl spinal anesthesia for ce- sarean delivery. Reg Anesth Pain Med 2000; 25(2): 235–39.
  • Siddik-Sayyid SM, Aouad MT, Jalbout MI, Zalaket MI, Berzina CE, Baraka AS: Intrathecal versus intrave- nous fentanyl for supplementation of subarachnoid block during cesarean delivery. Anesth Analg 2002; 95(2): 209-13.
  • Liao RZ, Peng JH, Chen YX, et al. Comparison of the block characteristics of levobupivacaine vs bupi- vacaine for unilateral spinal block. Di Yi Jun Yi Da Xue XueBao 2005; 25(10): 1563–7.
  • Erbay RH, Ermumcu O, Hanci V, et al. A compari- son of spinal anesthesiae with low-dose hyperbaric levobupivacaine and hyperbaric bupivacaine for tran- suretral surgery:a randomized controlled trial. Minevra Anestesiol 2010;76(9):992-1001.
  • Arslantaş R, Arşlantaş MK, Şitilci T ve ark. Ürolojik girişimlerde bupivakain ile levobupivakainin karşılaştı- rılması. TARD dergisi 2006; 257(2): 156-9.
There are 14 citations in total.

Details

Primary Language Turkish
Journal Section Research Article
Authors

Feyzi Çelik This is me

Adnan Tüfek This is me

Zeynep B. Yıldırım This is me

Orhan Tokgöz This is me

Haktan Karaman This is me

Celil Alemdar This is me

Ramazan Atiç This is me

Taner Çiftçi This is me

Gönül Ölmez Kavak This is me

Publication Date December 1, 2011
Published in Issue Year 2011 Volume: 2 Issue: 4

Cite

APA Çelik, F., Tüfek, A., Yıldırım, Z. B., Tokgöz, O., et al. (2011). Comparison of effectiveness of bupivacaine and levobupivacaine used in spinal anesthesia. Journal of Clinical and Experimental Investigations, 2(4), 388-391. https://doi.org/10.5799/ahinjs.01.2011.04.0078
AMA Çelik F, Tüfek A, Yıldırım ZB, Tokgöz O, Karaman H, Alemdar C, Atiç R, Çiftçi T, Kavak GÖ. Comparison of effectiveness of bupivacaine and levobupivacaine used in spinal anesthesia. J Clin Exp Invest. December 2011;2(4):388-391. doi:10.5799/ahinjs.01.2011.04.0078
Chicago Çelik, Feyzi, Adnan Tüfek, Zeynep B. Yıldırım, Orhan Tokgöz, Haktan Karaman, Celil Alemdar, Ramazan Atiç, Taner Çiftçi, and Gönül Ölmez Kavak. “Comparison of Effectiveness of Bupivacaine and Levobupivacaine Used in Spinal Anesthesia”. Journal of Clinical and Experimental Investigations 2, no. 4 (December 2011): 388-91. https://doi.org/10.5799/ahinjs.01.2011.04.0078.
EndNote Çelik F, Tüfek A, Yıldırım ZB, Tokgöz O, Karaman H, Alemdar C, Atiç R, Çiftçi T, Kavak GÖ (December 1, 2011) Comparison of effectiveness of bupivacaine and levobupivacaine used in spinal anesthesia. Journal of Clinical and Experimental Investigations 2 4 388–391.
IEEE F. Çelik, “Comparison of effectiveness of bupivacaine and levobupivacaine used in spinal anesthesia”, J Clin Exp Invest, vol. 2, no. 4, pp. 388–391, 2011, doi: 10.5799/ahinjs.01.2011.04.0078.
ISNAD Çelik, Feyzi et al. “Comparison of Effectiveness of Bupivacaine and Levobupivacaine Used in Spinal Anesthesia”. Journal of Clinical and Experimental Investigations 2/4 (December 2011), 388-391. https://doi.org/10.5799/ahinjs.01.2011.04.0078.
JAMA Çelik F, Tüfek A, Yıldırım ZB, Tokgöz O, Karaman H, Alemdar C, Atiç R, Çiftçi T, Kavak GÖ. Comparison of effectiveness of bupivacaine and levobupivacaine used in spinal anesthesia. J Clin Exp Invest. 2011;2:388–391.
MLA Çelik, Feyzi et al. “Comparison of Effectiveness of Bupivacaine and Levobupivacaine Used in Spinal Anesthesia”. Journal of Clinical and Experimental Investigations, vol. 2, no. 4, 2011, pp. 388-91, doi:10.5799/ahinjs.01.2011.04.0078.
Vancouver Çelik F, Tüfek A, Yıldırım ZB, Tokgöz O, Karaman H, Alemdar C, Atiç R, Çiftçi T, Kavak GÖ. Comparison of effectiveness of bupivacaine and levobupivacaine used in spinal anesthesia. J Clin Exp Invest. 2011;2(4):388-91.