The effect of acute decompansated hearth failure treatment on oxidative stress

Turgay Ulaş; Hakan Büyükhatipoğlu; Yusuf Sezen; Mehmet Sinan Dal; Timuçin Aydoğan; Mehmet Ali Eren; Mehmet Uçar; Nurten Aksoy; Recep Demirbağ

doi:10.18345/tm.50561

The effect of acute decompansated hearth failure treatment on oxidative stress

Year 2011, Volume: 2 Issue: 3, - , 01.09.2011

Turgay Ulaş Hakan Büyükhatipoğlu Yusuf Sezen Mehmet Sinan Dal Timuçin Aydoğan Mehmet Ali Eren Mehmet Uçar Nurten Aksoy Recep Demirbağ

https://doi.org/10.18345/tm.50561

Abstract

Objectives: Myocardial dysfunction in patients with hearth failure is suggested to occur due to membrane changes caused by oxidative stress. The aim of this study is to evaluate whether there is a relationship between the degree of hearth failure and oxidative stress, and the effect of hearth failure therapy on oxidative stress parameters. Materials and methods: We measured enzyme activities of catalase (CAT) and lipid hydroperoxide (LOOH) from blood samples of 67 patients with decompensate hearth failure (pre-treatment group), who have compensated with the treatment (post-treatment group, n=54) according to clinical findings and two-dimensional echocardiography and 47 healthy volunteers (control group). Results: We found CAT enzyme activities of patients with pre- and post-treatment groups were significantly lower than in control subjects (15.76±2.28 U/L; 17.36±1.55 U/L; 20.50±2.52 U/L, respectively, p

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The effect of acute decompansated hearth failure treatment on oxidative stress

Year 2011, Volume: 2 Issue: 3, - , 01.09.2011

Turgay Ulaş Hakan Büyükhatipoğlu Yusuf Sezen Mehmet Sinan Dal Timuçin Aydoğan Mehmet Ali Eren Mehmet Uçar Nurten Aksoy Recep Demirbağ

https://doi.org/10.18345/tm.50561

Abstract

Amaç: Kalp yetersizliği olan hastalarda miyokard disfonksiyonun, artmış oksidatif strese bağlı membran değişikliklerinden kaynaklanabileceği ileri sürülmektedir. Bu çalışmanın amacı oksidatif stres ile kalp yetersizliğindeki bozulmanın derecesi arasında bir ilişki olup olmadığını ve kalp yetersizliği tedavisinin oksidatif stres parametreleri üzerine etkisini araştırmaktır. Gereç ve yöntem: Klinik bulguları ve iki yönlü ekokardiyografi ile dekompanse kalp yetersizliği tanısı konulan 67 hasta (tedavi öncesi grup), tedavi ile kompansasyon sağlananlar (tedavi sonrası grup, n=54) ve 47 sağlıklı bireyden (kontrol grubu) alınan kan örneklerinden antioksidan enzimlerden katalaz (CAT) ve oksidan enzim olan lipit hidroperoksit (LOOH) aktiviteleri ölçüldü. Bulgular: CAT aktivitesi tedavi öncesi ve sonrası grupta kontrol grubuna göre istatistiksel olarak anlamlı düşük bulundu (sırasıyla 15.76±2.28 U/L; 17.36±1.55 U/L; 20.50±2.52 U/L, p

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Details

Primary Language	Turkish
Journal Section	Research Article
Authors	Turgay Ulaş This is me Hakan Büyükhatipoğlu This is me Yusuf Sezen This is me Mehmet Sinan Dal This is me Timuçin Aydoğan This is me Mehmet Ali Eren This is me Mehmet Uçar This is me Nurten Aksoy This is me Recep Demirbağ This is me
Publication Date	September 1, 2011
Published in Issue	Year 2011 Volume: 2 Issue: 3

Cite

APA	Ulaş, T., Büyükhatipoğlu, H., Sezen, Y., Dal, M. S., et al. (2011). The effect of acute decompansated hearth failure treatment on oxidative stress. Journal of Clinical and Experimental Investigations, 2(3). https://doi.org/10.18345/tm.50561
AMA	Ulaş T, Büyükhatipoğlu H, Sezen Y, Dal MS, Aydoğan T, Eren MA, Uçar M, Aksoy N, Demirbağ R. The effect of acute decompansated hearth failure treatment on oxidative stress. J Clin Exp Invest. September 2011;2(3). doi:10.18345/tm.50561
Chicago	Ulaş, Turgay, Hakan Büyükhatipoğlu, Yusuf Sezen, Mehmet Sinan Dal, Timuçin Aydoğan, Mehmet Ali Eren, Mehmet Uçar, Nurten Aksoy, and Recep Demirbağ. “The Effect of Acute Decompansated Hearth Failure Treatment on Oxidative Stress”. Journal of Clinical and Experimental Investigations 2, no. 3 (September 2011). https://doi.org/10.18345/tm.50561.
EndNote	Ulaş T, Büyükhatipoğlu H, Sezen Y, Dal MS, Aydoğan T, Eren MA, Uçar M, Aksoy N, Demirbağ R (September 1, 2011) The effect of acute decompansated hearth failure treatment on oxidative stress. Journal of Clinical and Experimental Investigations 2 3
IEEE	T. Ulaş, H. Büyükhatipoğlu, Y. Sezen, M. S. Dal, T. Aydoğan, M. A. Eren, M. Uçar, N. Aksoy, and R. Demirbağ, “The effect of acute decompansated hearth failure treatment on oxidative stress”, J Clin Exp Invest, vol. 2, no. 3, 2011, doi: 10.18345/tm.50561.
ISNAD	Ulaş, Turgay et al. “The Effect of Acute Decompansated Hearth Failure Treatment on Oxidative Stress”. Journal of Clinical and Experimental Investigations 2/3 (September 2011). https://doi.org/10.18345/tm.50561.
JAMA	Ulaş T, Büyükhatipoğlu H, Sezen Y, Dal MS, Aydoğan T, Eren MA, Uçar M, Aksoy N, Demirbağ R. The effect of acute decompansated hearth failure treatment on oxidative stress. J Clin Exp Invest. 2011;2. doi:10.18345/tm.50561.
MLA	Ulaş, Turgay et al. “The Effect of Acute Decompansated Hearth Failure Treatment on Oxidative Stress”. Journal of Clinical and Experimental Investigations, vol. 2, no. 3, 2011, doi:10.18345/tm.50561.
Vancouver	Ulaş T, Büyükhatipoğlu H, Sezen Y, Dal MS, Aydoğan T, Eren MA, Uçar M, Aksoy N, Demirbağ R. The effect of acute decompansated hearth failure treatment on oxidative stress. J Clin Exp Invest. 2011;2(3).