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Sympathetic skin responses in migraineurs

Year 2011, Volume: 2 Issue: 1, 16 - 21, 01.03.2011
https://doi.org/10.5799/ahinjs.01.2011.01.0204

Abstract

Objectives: The aim of this study was to compare the sympathetic nerve system profile of migraineurs during the headache-free periods to a group of normal subjects based on sympathetic skin response. Materials and methods: 82 patients with migraine (20 migraine with aura and 62 without aura) and 35 healthy volunteers who are age-and sex-matched patients with migraine selected randomly from the hospital personnel as a control group were enrolled in the study. Patients reporting at least one of the autonomic symptoms during the attack periods regularly were considered migraineurs with having autonomic symptoms. Sympathetic skin response test was applied on both sides of the upper and lower limbs of all subjects. Results: There were no subjects whose responses were absent for both right and left sides of upper and lower limbs. Patients with migraine had significantly longer sympathetic skin response latency than the control group. There was no significant difference between the mean latency and amplitude results in the migraine patients with and without aura or autonomic dysfunction or not (P>0.05). Additionally, sympathetic skin response amplitude values were not significantly different between the three groups (P>0.05). Conclusions: Migraine patients exhibited significantly longer sympathetic skin response latency than controls, leading to suggest that sympathetic hypofunction occurred in patients with migraine during the headache-free period.

References

  • Pietrobon D, Striessnig J. Neurobiology of migraine. Nat Rev Neurosci 2003; 4:386-398.
  • Benarroch EE. Pain-autonomic interactions: a selective re- view. Clin Auton Res 2001; 11:343-349.
  • Gutrecht JA. Sympathetic skin response. J Clin Neurosci 1994;11:519-524.
  • Vetrugno R, Liguori R, Cortelli P, Montagna P. Sympa- thetic skin response: Basic mechanisms and clinical appli- cations. Clin Auton Res 2003;13:256-270.
  • Peroutka SJ. Migraine: a chronic sympathetic nervous sys- tem disorder. Headache 2004; 44:53-64.
  • Atasoy HT, Atasoy N, Unal AE, Sumer M. Sympathetic skin response in migraineurs and patients with medication overuse headache. Headache 2004;44:305-310.
  • Yakinci C, Mungen B, Er H, Durmaz Y, Karabiber H. Autonomic nervous system function in childhood mi- graine. Pediatr Int 1999;41:529-533.
  • Kanzato N, Komine Y, Fukiyama K. Sympathetic skin re- sponses of the hand in normal subjects: shorter latency at distal 1997;105:165-170. Clin Neurophysiol
  • Drummond PD. Effects of body heating and mental arith- metic on facial sweating and blood flow in unilateral mi- graine headache. Psychophysiology 1991;28:172-176.
  • Gruzelier JH, Nicolaou T, Connolly JF, Peatfield RC, Da- vies PT, Clifford-Rose F. Laterality of pain in migraine distinguished by interictal rates of habituation of elec- trodermal responses to visual and auditory stimuli. J Neu- rol Nerosurg Psychiatry 1987;50:416-422.
  • Avnon Y, Nitzan M, Sprecher E, Rogowski Z, Yarnitsky D. Autonomic asymmetry in migraine: augmented para- sympathetic activation in left unilateral migraineurs. Brain 2004;127:2099-2108.

Migrenlilerdeki sempatik deri cevapları

Year 2011, Volume: 2 Issue: 1, 16 - 21, 01.03.2011
https://doi.org/10.5799/ahinjs.01.2011.01.0204

Abstract

Amaç: Bu çalışmanın amacı sempatik deri yanıtını kullanarak baş ağrısız dönemdeki migren hastaları ile kontrol grubundaki bireylerin sempatik sinir sistemi profilinin karşılaştırılmasıdır. Gereç ve yöntem: 82 migren hastası (20 auralı ve 62 aurasız) ile hastane personellerinden yaş ve cinsiyetle uyumlu olarak rastgele seçilen 35 gönüllünün olduğu kontrol grubu çalışmaya dahil edildi. Baş ağrısı ataklarına düzenli olarak en az bir otonomik semptomun eşlik ettiği hastalar otonomik semptomların olduğu hastalar olarak nitelendirildi. Tüm bireylere hem üst hem de alt ekstremitelerde sempatik deri cevabı testi uygulandı. Bulgular: Hem sağ hem de sol üst ve alt ekstremitelerden elde edilen cevabın olmadığı hiçbir birey yoktu. Migrenli hastaların sempatik deri cevabı latansları kontrol grubuna göre anlamlı derecede daha uzundu. Ortalama latans ve amplitüd değerleri auralıaurasız veya otonomik disfonksiyonun olduğu veya olmadığı hastalar arasında farklı değildi (P > 0,05). Ek olarak sempatik deri cevabı amplitüd değerleri de 3 grup arasında anlamlı derecede farklılık göstermedi (P > 0,05). Sonuç: Migrenliler, baş ağrısız dönemde daha uzun sempatik deri cevabı latansına sahiptir ki bu durum migrenlilerde kontrollere göre sempatik hipofonksiyonun olduğunu ortaya koymaktadır.

References

  • Pietrobon D, Striessnig J. Neurobiology of migraine. Nat Rev Neurosci 2003; 4:386-398.
  • Benarroch EE. Pain-autonomic interactions: a selective re- view. Clin Auton Res 2001; 11:343-349.
  • Gutrecht JA. Sympathetic skin response. J Clin Neurosci 1994;11:519-524.
  • Vetrugno R, Liguori R, Cortelli P, Montagna P. Sympa- thetic skin response: Basic mechanisms and clinical appli- cations. Clin Auton Res 2003;13:256-270.
  • Peroutka SJ. Migraine: a chronic sympathetic nervous sys- tem disorder. Headache 2004; 44:53-64.
  • Atasoy HT, Atasoy N, Unal AE, Sumer M. Sympathetic skin response in migraineurs and patients with medication overuse headache. Headache 2004;44:305-310.
  • Yakinci C, Mungen B, Er H, Durmaz Y, Karabiber H. Autonomic nervous system function in childhood mi- graine. Pediatr Int 1999;41:529-533.
  • Kanzato N, Komine Y, Fukiyama K. Sympathetic skin re- sponses of the hand in normal subjects: shorter latency at distal 1997;105:165-170. Clin Neurophysiol
  • Drummond PD. Effects of body heating and mental arith- metic on facial sweating and blood flow in unilateral mi- graine headache. Psychophysiology 1991;28:172-176.
  • Gruzelier JH, Nicolaou T, Connolly JF, Peatfield RC, Da- vies PT, Clifford-Rose F. Laterality of pain in migraine distinguished by interictal rates of habituation of elec- trodermal responses to visual and auditory stimuli. J Neu- rol Nerosurg Psychiatry 1987;50:416-422.
  • Avnon Y, Nitzan M, Sprecher E, Rogowski Z, Yarnitsky D. Autonomic asymmetry in migraine: augmented para- sympathetic activation in left unilateral migraineurs. Brain 2004;127:2099-2108.
There are 11 citations in total.

Details

Primary Language Turkish
Journal Section Research Article
Authors

Aysel Milanlıoğlu This is me

Temel Tombul This is me

Refah Sayın This is me

Publication Date March 1, 2011
Published in Issue Year 2011 Volume: 2 Issue: 1

Cite

APA Milanlıoğlu, A., Tombul, T., & Sayın, R. (2011). Migrenlilerdeki sempatik deri cevapları. Journal of Clinical and Experimental Investigations, 2(1), 16-21. https://doi.org/10.5799/ahinjs.01.2011.01.0204
AMA Milanlıoğlu A, Tombul T, Sayın R. Migrenlilerdeki sempatik deri cevapları. J Clin Exp Invest. March 2011;2(1):16-21. doi:10.5799/ahinjs.01.2011.01.0204
Chicago Milanlıoğlu, Aysel, Temel Tombul, and Refah Sayın. “Migrenlilerdeki Sempatik Deri Cevapları”. Journal of Clinical and Experimental Investigations 2, no. 1 (March 2011): 16-21. https://doi.org/10.5799/ahinjs.01.2011.01.0204.
EndNote Milanlıoğlu A, Tombul T, Sayın R (March 1, 2011) Migrenlilerdeki sempatik deri cevapları. Journal of Clinical and Experimental Investigations 2 1 16–21.
IEEE A. Milanlıoğlu, T. Tombul, and R. Sayın, “Migrenlilerdeki sempatik deri cevapları”, J Clin Exp Invest, vol. 2, no. 1, pp. 16–21, 2011, doi: 10.5799/ahinjs.01.2011.01.0204.
ISNAD Milanlıoğlu, Aysel et al. “Migrenlilerdeki Sempatik Deri Cevapları”. Journal of Clinical and Experimental Investigations 2/1 (March 2011), 16-21. https://doi.org/10.5799/ahinjs.01.2011.01.0204.
JAMA Milanlıoğlu A, Tombul T, Sayın R. Migrenlilerdeki sempatik deri cevapları. J Clin Exp Invest. 2011;2:16–21.
MLA Milanlıoğlu, Aysel et al. “Migrenlilerdeki Sempatik Deri Cevapları”. Journal of Clinical and Experimental Investigations, vol. 2, no. 1, 2011, pp. 16-21, doi:10.5799/ahinjs.01.2011.01.0204.
Vancouver Milanlıoğlu A, Tombul T, Sayın R. Migrenlilerdeki sempatik deri cevapları. J Clin Exp Invest. 2011;2(1):16-21.