Abstract
Objective: It was aimed to investigate the neutrophil, eosinophil, lymphocyte, platelet count, neutrophil to lymphocyte ratio (NLR) and mean platelet volume (MPV) in patients with vernal keratoconjunctivitis (VKC).Methods: The medical records of the VKC patients who admitted to ophthalmology polyclinic were evaluated. Age and sex matched control group was consisted with patients without any systemic or ocular disease except strabismus. Age and gender of all participants were recorded. Hemogram parameters such as mean platelet volume (MPV), neutrophil, eosinophil, lymphocyte, platelet count, NLR were measured by automatized analyzer. Data were compared between the groups.Results: Thirty patients and 30 control subjects were studied. There were no significant differences with respect to age and gender between groups. The mean MPV and NLR values were higher but not statistically significant in VKC group compared to control group (p=0.19, p=0.16, respectively). Conclusion: The results of the current study demonstrated that MPV and NLR values were not associated with VKC. Higher MPV and NLR results in patients with VKC although the differences were not reach statistically significances may suggest that MPV and NLR may be auxiliary parameter. J Clin Exp Invest 2015; 6 (1): 40-43
References
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- El-Asrar A.A, Al-Mansouri S, Tabbara K, et al. Immunopathogenesis
- of conjunctival remodeling in vernal
- keratoconjunctivitis. Eye 2005;20:71-79.
- Bonini S, Bonini S, Lambiase A, et al. Vernal keratoconjunctivitis
- revisited: a case series of 195 patients with
- long-term follow up. Ophthalmology 2000;107:1157-
- -
- Kosrirukvongs P, Vichyanond P, Wongsawad W. Vernal
- keratoconjunctivitis in Thailand. Asian Pac J Allergy
- Immunol 2003;21:25-30.
- Şahin A, Şahin M, Yüksel H, et al. The mean platelet
- volume in patients with retinal vein occlusion. J Ophthalmol
- ;236371.
- Çil H, Yavuz C, İslamoğlu Y, et al. Platelet count and
- mean platelet volume in patients with in-hospital
- deep venous thrombosis. Clin Appl Thromb Hemost
- ;18:650-653.
- Giles H, Smith R, Martin J. Platelet glycoprotein IIb-IIIa
- and size are increased in acute myocardial infarction.
- Eur J Clin Invest. 1994;24:69-72.
- Alkhouri N, Morris SG, Campbell C, et al. Neutrophil
- to lymphocyte ratio: a new marker for predicting steatohepatitis
- and fibrosis in patients with nonalcoholic
- fatty liver disease. Liver Int 2012;32:297-302.
- Cho SY, Lee A, Lee HJ, et al. Mean platelet volume
- in Korean patients with hepatic diseases. Platelets
- ;23:648-649.
- Arikanoglu A, Yucel Y, Acar A, et al. The relationship of
- the mean platelet volume and C-reactive protein levels
- with mortality in ischemic stroke patients. Eur Rev
- Med Pharmacol Sci 2013;17:1774-1777.
- Celik T, Kaya M.G, Akpek M, et al, Predictive value
- of admission platelet volume indices for in-hospital
- major adverse cardiovascular events in acute STsegment
- elevation myocardial infarction. Angiology
- ;66:155-162
- Ranjith M, Divya R, Mehta V, et al. Significance of
- platelet volume indices and platelet count in ischaemic
- heart disease. J Clin Pathol 2009;62:830-833.
- Hourani S, Cusack N. Pharmacological receptors on
- blood platelets. Pharmacol Rev 1991;43:243-298.
- Baudouin C, Liang H, Bremond G.D, et al. CCR4 and
- CCR5 expression in conjunctival specimens as differential
- markers of T< sub> H</sub> 1/T< sub> H</
- sub> 2 in ocular surface disorders. J Allergy Clin Immunol
- ;116:614-619.
- Aragona P, Romeo G, Puzzolo D, et al. Impression
- cytology of the conjunctival epithelium in patients with
- vernal conjunctivitis. Eye 1996;10:82-85.
- Rifaioglu E, Şen B, Ekiz Ö, Dogramaci A. Neutrophil
- to lymphocyte ratio in Behcet’s disease as a marker of
- disease activity. Acta Dermatovenerol Alp Pannonica
- Adriat 2014;23:65-67.
- Akboğa MK, Akyel A, Şahinarslan A, et al. Neutrophil
- to lymphocyte ratio is increased in patients with rheumatic
- mitral valve disease. Anadolu Kardiyol Derg
- ; [Epub ahead of print]
- Oray M, Toker E. Tear cytokine levels in vernal keratoconjunctivitis:
- the effect of topical 0.05% cyclosporine
- a therapy. Cornea 2013;32:1149-1154.
- Çatak O, Aydemir O, Üstündağ B. Vernal keratokonjonktivitte
- gözyaşı interlökin-16 düzeyleri. Dicle Med J
- ;40:422-425.
Abstract
Amaç: Bu çalışmada vernal keratokonjonktiviti (VKK) olan hastaların nötrofil, eozinofil, lenfosit, trombosit sayı- sı, nötrofil/lenfosit oranı (NLO), ortalama trombosit hacmi (MPV) değerlendirilmesi amaçlanmıştır. Yöntemler: Bu çalışmada göz hastalıkları polikliniğine başvurmuş ve VKK tanısı almış olguların dosya kayıtları retrospektif olarak incelendi. Şaşılık dışında herhangi bir sistemik ve oküler hastalığı bulunmayan yaş ve cinsiyet uyumlu olgular kontrol grubuna dahil edildi. Tüm katı- lımcıların yaş ve cinsiyet verileri kaydedildi. Hemogram değerlerinden; MPV nötrofil, eozinofil, lenfosit, trombosit sayımı, NLO otomatik analizörlerle ölçüldü. Elde edilen veriler iki grup arasında karşılaştırıldı. Bulgular: Çalışma kapsamında 30 VKK ve 30 kontrol olgusu değerlendirildi. Gruplar arasında yaş ve cinsiyet açısından anlamlı farklılık saptanmadı. MPV ve NLO, VKK grubunda kontrol grubuna oranla daha yüksek olmasına rağmen istatistiksel olarak anlamlı değildi (sırasıyla p=0,19 ve p=0,16). Sonuç: Bu çalışmanın sonucunda MPV ve NLO değerlerinin VKK hastalığıyla ilişkili olmadığını gösterilmiştir. MPV ve NLO değerlerinin VKK’da istatistiksel olarak anlamlı olmamalarına rağmen daha yüksek olması VKK için yardımcı parametre olarak kullanılabilir. Anahtar kelimeler: Nötrofil lenfosit oranı, ortalama trombosit hacmi, vernal keratokonjonktivit
References
- Kanski JJ. Clinical ophthalmology. A systematic approach
- nd ed Boston, Massachusetts: ButterworthHeinemann
- ;629.
- El-Asrar A.A, Al-Mansouri S, Tabbara K, et al. Immunopathogenesis
- of conjunctival remodeling in vernal
- keratoconjunctivitis. Eye 2005;20:71-79.
- Bonini S, Bonini S, Lambiase A, et al. Vernal keratoconjunctivitis
- revisited: a case series of 195 patients with
- long-term follow up. Ophthalmology 2000;107:1157-
- -
- Kosrirukvongs P, Vichyanond P, Wongsawad W. Vernal
- keratoconjunctivitis in Thailand. Asian Pac J Allergy
- Immunol 2003;21:25-30.
- Şahin A, Şahin M, Yüksel H, et al. The mean platelet
- volume in patients with retinal vein occlusion. J Ophthalmol
- ;236371.
- Çil H, Yavuz C, İslamoğlu Y, et al. Platelet count and
- mean platelet volume in patients with in-hospital
- deep venous thrombosis. Clin Appl Thromb Hemost
- ;18:650-653.
- Giles H, Smith R, Martin J. Platelet glycoprotein IIb-IIIa
- and size are increased in acute myocardial infarction.
- Eur J Clin Invest. 1994;24:69-72.
- Alkhouri N, Morris SG, Campbell C, et al. Neutrophil
- to lymphocyte ratio: a new marker for predicting steatohepatitis
- and fibrosis in patients with nonalcoholic
- fatty liver disease. Liver Int 2012;32:297-302.
- Cho SY, Lee A, Lee HJ, et al. Mean platelet volume
- in Korean patients with hepatic diseases. Platelets
- ;23:648-649.
- Arikanoglu A, Yucel Y, Acar A, et al. The relationship of
- the mean platelet volume and C-reactive protein levels
- with mortality in ischemic stroke patients. Eur Rev
- Med Pharmacol Sci 2013;17:1774-1777.
- Celik T, Kaya M.G, Akpek M, et al, Predictive value
- of admission platelet volume indices for in-hospital
- major adverse cardiovascular events in acute STsegment
- elevation myocardial infarction. Angiology
- ;66:155-162
- Ranjith M, Divya R, Mehta V, et al. Significance of
- platelet volume indices and platelet count in ischaemic
- heart disease. J Clin Pathol 2009;62:830-833.
- Hourani S, Cusack N. Pharmacological receptors on
- blood platelets. Pharmacol Rev 1991;43:243-298.
- Baudouin C, Liang H, Bremond G.D, et al. CCR4 and
- CCR5 expression in conjunctival specimens as differential
- markers of T< sub> H</sub> 1/T< sub> H</
- sub> 2 in ocular surface disorders. J Allergy Clin Immunol
- ;116:614-619.
- Aragona P, Romeo G, Puzzolo D, et al. Impression
- cytology of the conjunctival epithelium in patients with
- vernal conjunctivitis. Eye 1996;10:82-85.
- Rifaioglu E, Şen B, Ekiz Ö, Dogramaci A. Neutrophil
- to lymphocyte ratio in Behcet’s disease as a marker of
- disease activity. Acta Dermatovenerol Alp Pannonica
- Adriat 2014;23:65-67.
- Akboğa MK, Akyel A, Şahinarslan A, et al. Neutrophil
- to lymphocyte ratio is increased in patients with rheumatic
- mitral valve disease. Anadolu Kardiyol Derg
- ; [Epub ahead of print]
- Oray M, Toker E. Tear cytokine levels in vernal keratoconjunctivitis:
- the effect of topical 0.05% cyclosporine
- a therapy. Cornea 2013;32:1149-1154.
- Çatak O, Aydemir O, Üstündağ B. Vernal keratokonjonktivitte
- gözyaşı interlökin-16 düzeyleri. Dicle Med J
- ;40:422-425.
Details
| Primary Language | Turkish |
|---|---|
| Journal Section | Research Article |
| Authors | |
| Publication Date | May 10, 2015 |
| Published in Issue | Year 2015 Volume: 6 Issue: 1 |