Abstract
Objective: Carpal tunnel syndrome (CTS) is formed by the compression of median nerve passes under the level of the transverse carpal ligament at the level of the wrist. CTS is the most common type of entrapment neuropathy. Mostly underlying cause of this entrapment is unknown. Mean platelet volume (MPV), is an important indicator in a positive direction for platelet activation and function. In this study, increased thrombocyte activation due to increased mean thrombocyte volume is whether an important indicator for CTS diagnosis or not was researched.Methods: In this study, 418 patients diagnosed with CTS and 120 controls were enrolled, including 538 people. In both groups, demographic data, and hemoglobin (HGB), mean corpuscular volume (MCV), red cell distribution width (RDW), platelet count (PLT), MPV, platelet distribution width (PDW) parameters were evaluated.Results: The mean HGB, MCV values were significantly lower in the CTS group than those of controls(p <0.001). RDW, PDW values were statistically higher in the CTS group (p <0.001). The mean MPV was significantly different between groups (p <0.005). The mean PLT did not reach statistically significant difference between groups (p = 0,484).Conclusion: The results of our study demonstrated that the increased MPV and PDW values and other related hemogram parameters (HGB, MCV, RDW) may provide useful information in the diagnosis and be predictive in patients with CTS. J Clin Exp Invest 2015; 6 (2): 154-158
Keywords
References
- Werner RA, Andary M. Carpal tunnel syndrome: pathophysiology and clinical neurophysiology. Clin Neurophysiol 2002;113:1370-1381.
- Ertekin C. Klinik Elektromiyografi. İzmir: Ege Üniversitesi Matbaası; 261-265,1977
- Rosenbaum R. Carpal Tunnel Syndrome. In: Jhonson RT, Griffin WJ: Current therapy in neurologic disease. 5th ed. USA: Mosby –Yearbook Inc.:374-377,1997.
- Adams RD, Victor M, Ropher AH. Principles Of Neurology. 6th ed, New York: Mc Graw-Hill;1278-1385.
- Rengachary SS. Entrapment neuropathies. In: Wilkins RH, Rengachary SS, editors. Neurosurgery. International ed. The McGraw-Hill Companies; 1996. p.3073-3098.
- Tanık N, Sarp Ü, Çelikbilek A, et al. Carpal tunnel syndrome: An evaluation clinical and sociodemographic characteristics of 350 patients. Dicle Med J 2014;41:538-541.
- Franklin GM, Haug J, Heyer N, et al. Occupational carpal tunnel syndrome in Washington State, 1984-1988. Am J Public Health 1991;81:741-746.
- Sunderland S. Thenervelesion in the carpal tunnel syndrome. J Neurol Neurosurg Psychiatry 1976;39:615-626.
- Ertekin C. Nörolojide fizyopatoloji ve tedavi. İzmir: Bilgehan Yayınları,p 365-387,1987.
- Bath PM, Butterworth RJ. Platelet size: measurement, physiology and vascular disease. Blood Coagul Fibrinolysis 1996;7:157-161.
- Cameron HA, Phillips R, Ibbotson RM, Carson PH. Platelet size in myocardial infarction. Br Med J (Clin Res Ed) 1983;287:449-451.
- Kario K, Matsuo T, Nakao K. Cigarette smoking increases the mean platelet volume in elderly patients with risk factors for atherosclerosis. Clin Lab Hematol 1992;14:281-287.
- Bath PM, Missouris CG, Buckenham T, MacGregor GA. Increased platelet volume and platelet mass in patients with atherosclerotic renal artery stenosis. Clin Sci (Lond) 1994;87:253-257.
- Thompson CB, Eaton KA, Princiotta SM, et al. Size dependent platelet subpopulations: relationship of platelet volume to ultrastructure, enzymatic activity, and function. Br J Haematol 1982;50:509-519.
- Briggs C. Quality counts: new parameters in blood cell counting. Int J Lab Hematol 2009;31:277-297.
- Akgul O, Uyarel H, Pusuroglu H, et al. Prognostic value of elevated mean platelet volume in patients undergoing primary angioplasty for ST-elevation myocardial infarction. Acta Cardiol 2013;68:307-314.
- Erden EŞ, Dokuyucu R, Demirköse M, et al. Investigation of mean platelet volume in chronic obstructive pulmonary disease during stable and acute exacerbation. J Clin Exp Invest 2013;4:483-487.
- Buckley MF, James JW, Brown DE, et al. A novel approach to the assessment of variations in the human platelet count. ThrombHaemost 2000;83:80-484.
- Kilicli-Camur N, Demirtunc R, Konuralp C, et al. Could mean platelet volume be a predictive marker for acute myocardial infarction? Med Sci Monit 2005;11:387-392.
- Freynhofer MK, Tajsic M, Wojta J, Huber K. Biomarkers in acute coronary artery disease. Wien Med Wochenschr 2012;162:489-498.
- Gasparyan AY, Ayvazyan L, Mikhailidis DP, Kitas GD.
- Mean platelet volume: a link between thrombosis and inflammation? Curr Pharm Des 2011;17:47-58.
- Arikanoglu A, Yucel Y, Acar A, et al. The relationship of
- the mean platelet volume and C-reactive protein levels with mortality in ischemic stroke patients. Eur Rev Med Pharmacol Sci 2013;17:1774-1777.
- Güldiken B, Özkan H, Kabayel L. Akut iskemik inmede ortalama trombosit hacmi ve periferik kan hücre sayısı yanıtı. Trakya Univ Tıp Fak Derg 2008;25:130-135.
- Tohgi H, Suzuki H, Tamura K, Kimura B. Platelet volume, aggregation, and adenosinetriphosphate release in cerebral thrombosis. Stroke 1991;22:17-21.
- Öztürk S, Doğan İ, KaramanK, et al. Ortalama trombosit hacmi; Akut ST elevasyonlu miyokard enfarktüsünde infarkt büyüklüğünün öngördürücüsü değildir. Abant Med 2012;1:120-124.
- Erden EŞ, Yengil E, et al. Obstrüktif uyku apne sendromu ile ortalama trombosit hacmi arasındaki ilişkinin incelenmesi. J Clin Exp Invest 2013:4:492-496.
- Bath PM. Theroutine measurement of platelet size using sodiumcitrate alone as the anticoagulant. ThrombHaemost 1993;70:687-690.
Karpal tünel sendromu olan hastalarda ortalama trombosit hacmi ve diğer hemogram sonuçlarının karşılaştırılması
Abstract
Amaç: Karpal tünel sendromu (KTS) el bileği düzeyinde median sinirin, transvers karpal ligamanın altından geçtiği seviyede sıkışması ile oluşur. KTS en sık görülen tuzak nöropati tipidir. Ortalama trombosit hacmi (MPV), trombosit aktivasyonu ve fonksiyonu için pozitif yönde önemli bir göstergedir. Bu çalışmada KTS tanısı konulan hastalarda artmış trombosit aktivasyonunun ve bu doğrultuda artmış trombosit hacminin KTS’nin varlığında önemli bir belirteç olup olamayacağı araştırılmak istenmiştir.Yöntemler: Bu çalışmaya 418 KTS tanısı konulan hasta ve 120 kontrol grubu olmak üzere 538 kişi alındı. Her iki grubun demografik verileri ve hemoglobin (HGB), ortalama eritrosit hacmi (MCV), eritrosit dağılım aralığı (RDW), trombosit sayısı (PLT), MPV, trombosit dağılım aralığı (PDW) içeren laboratuvar parametreleri değerlendirildi.Bulgular: Kontrol grubu ile karşılaştırıldığında HGB, MCV değerleri KTS grubunda istatiksel anlamlı şekilde daha düşük bulundu (p < 0,001), RDW, PDW değerleri KTS grubunda istatistiksel olarak daha yüksek idi (p < 0,001). KTS’li grubun ortalama MPV değeri ile kontrol grubunun ortalama MPV değerleri arasındaki fark istatiksel olarak anlamlı bulundu (p < 0,005). KTS grubunun PLT ortalama değeri ile kontrol grubunun PLT ortalama değeri arasında istatiksel olarak anlamlı fark bulunamamıştır (p=0,484).Sonuç: Bu çalışmada KTS tanısı konulan hastalarda artmış MPV ve artan PDW değerlerinin diğer eritrositler ile ilgili hemogram parametrelerinin (HGB, MCV, RDW) KTS’ nin seyri ve prognozu açısından fikir verebileceği ve öngörüde bulunulabilmesinde faydalı olabileceği sonucuna vardık.
References
- Werner RA, Andary M. Carpal tunnel syndrome: pathophysiology and clinical neurophysiology. Clin Neurophysiol 2002;113:1370-1381.
- Ertekin C. Klinik Elektromiyografi. İzmir: Ege Üniversitesi Matbaası; 261-265,1977
- Rosenbaum R. Carpal Tunnel Syndrome. In: Jhonson RT, Griffin WJ: Current therapy in neurologic disease. 5th ed. USA: Mosby –Yearbook Inc.:374-377,1997.
- Adams RD, Victor M, Ropher AH. Principles Of Neurology. 6th ed, New York: Mc Graw-Hill;1278-1385.
- Rengachary SS. Entrapment neuropathies. In: Wilkins RH, Rengachary SS, editors. Neurosurgery. International ed. The McGraw-Hill Companies; 1996. p.3073-3098.
- Tanık N, Sarp Ü, Çelikbilek A, et al. Carpal tunnel syndrome: An evaluation clinical and sociodemographic characteristics of 350 patients. Dicle Med J 2014;41:538-541.
- Franklin GM, Haug J, Heyer N, et al. Occupational carpal tunnel syndrome in Washington State, 1984-1988. Am J Public Health 1991;81:741-746.
- Sunderland S. Thenervelesion in the carpal tunnel syndrome. J Neurol Neurosurg Psychiatry 1976;39:615-626.
- Ertekin C. Nörolojide fizyopatoloji ve tedavi. İzmir: Bilgehan Yayınları,p 365-387,1987.
- Bath PM, Butterworth RJ. Platelet size: measurement, physiology and vascular disease. Blood Coagul Fibrinolysis 1996;7:157-161.
- Cameron HA, Phillips R, Ibbotson RM, Carson PH. Platelet size in myocardial infarction. Br Med J (Clin Res Ed) 1983;287:449-451.
- Kario K, Matsuo T, Nakao K. Cigarette smoking increases the mean platelet volume in elderly patients with risk factors for atherosclerosis. Clin Lab Hematol 1992;14:281-287.
- Bath PM, Missouris CG, Buckenham T, MacGregor GA. Increased platelet volume and platelet mass in patients with atherosclerotic renal artery stenosis. Clin Sci (Lond) 1994;87:253-257.
- Thompson CB, Eaton KA, Princiotta SM, et al. Size dependent platelet subpopulations: relationship of platelet volume to ultrastructure, enzymatic activity, and function. Br J Haematol 1982;50:509-519.
- Briggs C. Quality counts: new parameters in blood cell counting. Int J Lab Hematol 2009;31:277-297.
- Akgul O, Uyarel H, Pusuroglu H, et al. Prognostic value of elevated mean platelet volume in patients undergoing primary angioplasty for ST-elevation myocardial infarction. Acta Cardiol 2013;68:307-314.
- Erden EŞ, Dokuyucu R, Demirköse M, et al. Investigation of mean platelet volume in chronic obstructive pulmonary disease during stable and acute exacerbation. J Clin Exp Invest 2013;4:483-487.
- Buckley MF, James JW, Brown DE, et al. A novel approach to the assessment of variations in the human platelet count. ThrombHaemost 2000;83:80-484.
- Kilicli-Camur N, Demirtunc R, Konuralp C, et al. Could mean platelet volume be a predictive marker for acute myocardial infarction? Med Sci Monit 2005;11:387-392.
- Freynhofer MK, Tajsic M, Wojta J, Huber K. Biomarkers in acute coronary artery disease. Wien Med Wochenschr 2012;162:489-498.
- Gasparyan AY, Ayvazyan L, Mikhailidis DP, Kitas GD.
- Mean platelet volume: a link between thrombosis and inflammation? Curr Pharm Des 2011;17:47-58.
- Arikanoglu A, Yucel Y, Acar A, et al. The relationship of
- the mean platelet volume and C-reactive protein levels with mortality in ischemic stroke patients. Eur Rev Med Pharmacol Sci 2013;17:1774-1777.
- Güldiken B, Özkan H, Kabayel L. Akut iskemik inmede ortalama trombosit hacmi ve periferik kan hücre sayısı yanıtı. Trakya Univ Tıp Fak Derg 2008;25:130-135.
- Tohgi H, Suzuki H, Tamura K, Kimura B. Platelet volume, aggregation, and adenosinetriphosphate release in cerebral thrombosis. Stroke 1991;22:17-21.
- Öztürk S, Doğan İ, KaramanK, et al. Ortalama trombosit hacmi; Akut ST elevasyonlu miyokard enfarktüsünde infarkt büyüklüğünün öngördürücüsü değildir. Abant Med 2012;1:120-124.
- Erden EŞ, Yengil E, et al. Obstrüktif uyku apne sendromu ile ortalama trombosit hacmi arasındaki ilişkinin incelenmesi. J Clin Exp Invest 2013:4:492-496.
- Bath PM. Theroutine measurement of platelet size using sodiumcitrate alone as the anticoagulant. ThrombHaemost 1993;70:687-690.
Details
| Primary Language | Turkish |
|---|---|
| Journal Section | Research Article |
| Authors | |
| Publication Date | July 10, 2015 |
| Published in Issue | Year 2015 Volume: 6 Issue: 2 |