Successful Treatment of MuSK Antibody–Positive Myasthenia Gravis with Rituximab

Year 2025, Volume: 25 Issue: 3, 172 - 175, 31.10.2025

Arife Derda Yücel Şen , Ahmet Baysal , Özlem Uğur , Kürşat Bora Çarman , Coşkun Yarar

https://doi.org/10.26650/jchild.2025.1704940

https://izlik.org/JA96LY87XP

Abstract

Muscle-specific tyrosine kinase antibody-associated myasthenia gravis (MuSK-MG) is a rare subtype of MG distinguished by recurring relapses and a clinical history unresponsive to conventional therapies. Rituximab, a monoclonal antibody that targets CD20+ B cells, has effectively induced long-term remission in adults. We report a pediatric MuSK-MG patient who exhibited a favourable response to rituximab following the ineffectiveness of steroid therapy and acetylcholinesterase inhibitor (AChEI) therapy.

Keywords

Child , myasthenia gravis , MUSK

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