A Rare Adverse Effect of Cetirizine in a 7- Month-Old Infant: Dystonic Reaction

Abstract

Cetirizine is a selective H1 histamine receptor antagonist derived from piperazine. Piperazine is a cyclic moiety molecule located in the structure of many drugs, including anxiolytics, antidepressants, and antipsychotics. Drug-induced dystonia is reported mostly due to antipsychotic and antiemetic drugs. It occurs due to the disruption of dopamine and acetylcholine balance in favor of acetylcholine. Although cetirizine is a relatively safe drug, it has rarely been reported to cause a dystonic reaction. To the best of our knowledge, there is no reported case of dystonia due to cetirizine in infancy. Here, we present a 7-month-old patient who developed a dystonic reaction after cetirizine administration.

Keywords

• Acute dystonia
• cetirizine
• infant

Yedi Aylık Bebekte Setirizin’in Nadir Bir Yan Etkisi: Distonik Reaksiyon

Abstract

Setirizin, piperazinden türetilen seçici bir H1 histamin reseptör antagonis- tidir. Piperazin, anksiyolitikler, antidepresanlar ve antipsikotikler dahil olmak üzere birçok ilacın yapısında yer alan siklik bir moleküldür. İlaca bağlı distoni, çoğunlukla antipsikotik ve antiemetik ilaçlara bağlı olarak bildirilmektedir. Dopamin ve asetilkolin dengesinin asetilkolin lehine bozulması sonucu oluşur. Setirizin nispeten güvenli bir ilaç olmasına rağ- men, nadiren distonik reaksiyona neden olduğu bildirilmiştir. Şimdiye kadar süt çocukluğu döneminde setirizine bağlı olarak bildirilmiş bir dis- toni vakası yoktur. Burada setirizin uygulaması sonrası distonik reaksiyon gelişen 7 aylık bir hasta sunulmuştur.

Keywords

• Akut distoni
• setirizin
• sütçocuğu

References

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